Elsevier

NeuroImage

Volume 11, Issue 4, April 2000, Pages 347-357
NeuroImage

Rapid Communication
A Common Language Network for Comprehension and Production: A Contribution to the Definition of Language Epicenters with PET

https://doi.org/10.1006/nimg.2000.0546Get rights and content

Abstract

In this paper, we report on a PET activation study designed to assess whether functional neuroimaging would help to uncover essential language areas in normal volunteers and to provide a more accurate definition of their localization. Regional cerebral blood flow was repeatedly monitored in eight right-handed male volunteers, while performing a language comprehension task (listening to factual stories) and a language production task (covert generation of verbs semantically related to heard nouns), using silent resting as a control condition. The conjunction analysis, conducted with SPM, was used to uncover the network of activations common to both task that included three left hemisphere areas, namely (1) the pars opercularis and triangularis of the inferior frontal gyrus, (2) the posterior part of the superior temporal cortex centered around the superior temporal sulcus, extending to the planum temporale posterior part but sparing the supramarginalis and angular gyri, and (3) the most anterior part of the left inferior temporal gyrus at the junction with the anterior fusiform gyrus. The inferior and lateral parts of the right cerebellar cortex were also included in the conjunction network. Each of the three cortical areas, when they are site of lesion or electrical stimulation, elicit impairment in both language comprehension and production and can thus be considered as essential to language. Accordingly, the present results provide conservative anatomofunctional definitions of the Broca, Wernicke, and basal language areas. Interestingly, contralateral homologues of Broca's and Wernicke's areas also lighted up in the conjunction analysis that could be related to the interindividual variability of hemispheric language dominance.

References (70)

  • R.C. Oldfield

    The assessment and analysis of handedness: The Edinburgh inventory

    Neuropsychologia

    (1971)
  • R.A. Poldrack et al.

    Functional specialization for semantic and phonological processing in the left inferior prefrontal cortex

    Neuroimage

    (1999)
  • J.-B. Poline et al.

    Reproducibility of PET activation studies: Lessons from a multicenter european experiment. EU concerted action on functional imaging

    Neuroimage

    (1996)
  • C. Price et al.

    Regional response differences within the human auditory cortex when listening to words

    Neurosci. Letters

    (1992)
  • K. Stromswold et al.

    Localization of syntactic comprehension by positron emission tomography

    Brain Lang.

    (1996)
  • A. Thiel et al.

    Localization of language-related cortex with O-15-labeled water PET in patients with gliomas

    Neuroimage

    (1998)
  • N. Tzourio et al.

    Functional anatomy of human auditory attention studied with PET

    Neuroimage

    (1997)
  • E. Zaidel

    Auditory vocabulary of the right hemisphere following brain bisection or hemidecortication

    Cortex

    (1976)
  • M.P. Alexander et al.

    Broca's area aphasias: Aphasia after lesions including the frontal operculum

    Neurology

    (1990)
  • K. Amunts et al.

    Broca's region revisited: Cytoarchitecture and intersubject variability

    J. Comp. Neurol.

    (1999)
  • E. Artiges et al.

    Altered hemispheric dominance during word generation in negative schizophrenia

    Schizophrenia Bull.

    (1998)
  • P. Belin et al.

    The functional anatomy of sound intensity discrimination

    J. Neurosci.

    (1998)
  • P. Belin et al.

    Recovery from nonfluent aphasia after melodic intonation therapy: A PET study

    Neurology

    (1996)
  • J.R. Binder et al.

    Function of the left planum temporale in auditory and linguistic processing

    Brain

    (1996)
  • J.E. Bogen et al.

    Wernicke's region-Where is it

    Ann. N.Y. Acad. Sci.

    (1976)
  • S.Y. Bookheimer et al.

    Regional cerebral blood flow during auditory responsive naming: Evidence for cross-modality neural activation

    NeuroReport

    (1998)
  • P. Broca

    Remarques sur le siège de la faculté du language articulé, suivies d'une observation d'aphémie (perte de la parole)

    Bull. Mémoires Soc. Anat. Paris

    (1861)
  • T.H. Burnstine et al.

    Characterization of the basal temporal language area in patients with left temporal lobe epilepsy

    Neurology

    (1990)
  • C. Büchel et al.

    A multimodal language region in the ventral visual pathway

    Nature

    (1998)
  • A.R. Damasio

    Aphasia

    N. Engl. J. Med.

    (1992)
  • N.F. Dronkers

    A new brain region for coordinating speech articulation

    Nature

    (1996)
  • O. Etard et al.

    Picture naming without Broca and Wernicke's areas

    NeuroReport

    (1999)
  • J.A. Fiez et al.

    PET activation of posterior temporal regions during auditory word presentation and verb generation

    Cereb. Cortex

    (1996)
  • K.J. Friston et al.

    Statistical parametric maps in functional imaging: a general linear approach

    Hum. Brain Mapp.

    (1995)
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