Abstract
Neurotrophins are a class of factors known to be involved in the development, maintenance, plasticity and survival of the peripheral and central nervous systems1. Neurotrophins are active through high-affinity receptors having an intrinsic tyrosine-kinase activity2,3. One of these neurotrophins, the brain-derived neurotrophic factor (BDNF) has been shown to be involved in a wide range of developmental and plasticity mechanisms and its biological action depends mainly upon activation of the TrkB receptor sub-type and to a less extent to the p75 receptors. BDNF binding on TrkB receptors initiates a cascade of events of phosphorylation that activate a complex of signal proteins and the induction of several genes4.
Supported by European grant QLG2/CT/2001-01467.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
E. J. Huang and L. F. Reichardt, Neurotrophins: role in neuronal development and function, Aram. Rev. Neurosci. 24, 677–736 (2001).
M. Barbacid, The Trk family of neurotrophin receptors, J. Neurobiol. 25, 1386–1403 (1994).
E. J. Huang and L. F. Reichardt, Trk receptors: Roles in neuronal signal transduction, Annu. Rev. Biochem. 72, 609–642 (2003).
R. A. Segal and M. E. Greenberg, Intracellular signaling pathways activated by neurotrophic factors, Annu. Rev. Neurosci. 19, 463–489 (1996).
J. T. Erickson, J. C. Conover, V. Borday, J. Champagnat, M. Barbacid, G. Yancopoulos and D. M. Katz, Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing, J. Neurosci. 16, 5361–5371 (1996).
A. Balkowiec, and D. M. Katz, Brain-derived neurotrophic factor is required for normal development of the central respiratory rhythm in mice, J. Physiol. (London) 510, 527–533 (1998).
J. C. Smith, H. H. Ellenberger, K. Ballanyi, D. W. Richter and J. L. Feldman, Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals, Science 254, 726–729 (1991).
J. C. Rekling and J. L. Feldman, Pre-Bötzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation, Annu. Rev. Physiol. 60, 385–405 (1998).
J. M. Ramirez, U. J. A. Quellmalz and D. W. Richter, Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice preparation of mice, J. Physiol. (London). 491, 799–812. (1996).
B. Cauli, E. Audinat, B. Lambolez, M. C. Angulo, N. Ropert, K. Tsuzuki S. Hestrin and J. Rossier, Molecular and physiological diversity of cortical non-pyramidal cells, J. Neurosci. 17, 3894–3906 (1997).
M. Thoby-Brisson, B. Cauli, J. Champagnat, G. Fortin and D. M. Katz, Expression of functional tyrosine kinase B receptors by rhythmically active respiratory neurons in the pre-Bötzinger complex of neonatal mice, J. Neurosci. 23, 7685–7689 (2003).
M. Thoby-Brisson, P. Telgkamp and J. M. Ramirez, The role of the hyperpolarization-activated current in modulating rhythmic activity in the isolated respiratory neural network of mice, J. Neurosci. 20, 2994–3005 (2000).
F. F. Eide, E. R. Vining, B. L. Eide, K. Zang, X. Y. Wang and L. F. Reichardt, Naturally occurring truncated trkB receptors have dominant inhibiting effects on brain-derived neurotrophic factor signaling, J. Neurosci. 16, 3123–3129 (1996).
R. M. Lindsay, S. J. Wiegand, C. A. Altar and P. S. DiStefano, Neurotrophic factors: from molecule to man, TINS. 17, 182–190 (1994).
M. Bibel, E. Hoppe, and Y. A. Barde, Biochemical and functional Interactions between the neurotrophin receptors TrkB and p75NTR, EMBO J. 18, 616–622 (1999).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Kluwer Academic/Plenum Publishers, New York
About this paper
Cite this paper
Thoby-Brisson, M., Autran, S., Fortin, G., Champagnat, J. (2004). BDNF Preferentially Targets Membrane Properties of Rhythmically Active Neurons in the pre-Bötzinger Complex in Neonatal Mice. In: Champagnat, J., Denavit-Saubié, M., Fortin, G., Foutz, A.S., Thoby-Brisson, M. (eds) Post-Genomic Perspectives in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 551. Springer, Boston, MA. https://doi.org/10.1007/0-387-27023-X_18
Download citation
DOI: https://doi.org/10.1007/0-387-27023-X_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-48507-7
Online ISBN: 978-0-387-27023-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)