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Inflammation-Associated Depression: Evidence, Mechanisms and Implications pp 31–44Cite as

Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 31))

Abstract

The finding that inflammatory markers are elevated in various neuropsychiatric disorders raises the need of identifying the precise research domain criteria driven by inflammation. Based on the model of inflammation-induced depression it has been possible to identify distinct pathophysiological pathways leading to alterations in neurotransmitter metabolism with specific relevance for the development of symptom constellations that are common to various neuropsychiatric and neurodegenerative conditions. Moreover, converging data indicate that these pathways interact with relevant vulnerability factors and modulatory systems to ultimately impact the presentation of inflammation-driven neuropsychiatric symptoms. Altogether, these findings make inflammation a key pivotal factor in psychopathology. Developing treatments that target inflammation and modulate the pathways and systems by which inflammatory processes selectively affect brain function will be of particular relevance for the treatment of specific neurobehavioral symptom domains.

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Conflict of Interest Statement

The authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Laboratory of Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, INRA, University Victor Segalen Bordeaux 2, 146 rue Léo Saignat, F-33076, Bordeaux, France

    Lucile Capuron & Nathalie Castanon

  2. INRA, Laboratory of Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, University of Bordeaux, F-33076, Bordeaux, France

    Lucile Capuron & Nathalie Castanon

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  1. Lucile Capuron
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  2. Nathalie Castanon
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Correspondence to Lucile Capuron .

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Editors and Affiliations

  1. Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Robert Dantzer

  2. Nutrition and Integrative Neurobiology, INRA, University of Bordeaux, Bordeaux, France

    Lucile Capuron

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Capuron, L., Castanon, N. (2016). Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms. In: Dantzer, R., Capuron, L. (eds) Inflammation-Associated Depression: Evidence, Mechanisms and Implications. Current Topics in Behavioral Neurosciences, vol 31. Springer, Cham. https://doi.org/10.1007/7854_2016_14

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