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Renal Cell Carcinoma

Molecular Targets and Clinical Applications

  • Thoroughly updated edition focusing on new and recent developments in renal cell carcinoma
  • Provides updated information on the rapidly evolving field of renal cell carcinoma personalized medicine, with an emphasis on novel targets and therapy
  • Discusses the significant amount of new biologic and clinical information such as refinement of the RCC systemic treatment paradigm, immunoregulatory abnormalities in RCC, and adjuvant and neoadjuvant therapy?
  • Includes supplementary material: sn.pub/extras

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xviii
  2. Targeted Therapy for Metastatic Renal Cell Carcinoma: Introduction

    • Ronald M. Bukowski, Robert A. Figlin, Robert J. Motzer
    Pages 1-14
  3. Genomic Assessment of Renal Cancer

    • Stephen M. Keefe, W. Kimryn Rathmell, Katherine L. Nathanson
    Pages 39-56
  4. PBRM1: A Critical Subunit of the SWI/SNF Chromatin Remodeling Complex

    • Chung-Han Lee, Can G. Pham, James J. Hsieh
    Pages 111-151
  5. Sporadic RCC: Abnormalities in Histone-Modifying Genes

    • Ruhee Dere, Thai H. Ho
    Pages 153-165
  6. Genetic Heterogeneity in Renal Cell Carcinoma: Clinical Implications?

    • Susan A. J. Vaziri, Mahrukh K. Ganapathi, Ram N. Ganapathi
    Pages 167-176
  7. Anti-VEGF and VEGFR Monoclonal Antibodies in RCC

    • Bernard Escudier, Laurence Albiges
    Pages 237-252
  8. PI3-kinase, Akt, and mTOR Inhibitors in RCC

    • Daniel C. Cho, James W. Mier
    Pages 253-262
  9. Carbonic Anhydrase IX and Monoclonal Antibody G250: Relevance as a Clinical and Biologic Target in Renal Cell Carcinoma

    • Egbert Oosterwijk, Otto C. Boerman, Jeannette C. Oosterwijk-Wakka, Wim J. Oyen, Peter F. A. Mulders
    Pages 263-284
  10. EGFR and HER2: Relevance in Renal Cell Carcinoma

    • Sarathi Kalra, Eric Jonasch
    Pages 285-302
  11. The Role of Hepatocyte Growth Factor Pathway Signaling in Renal Cell Carcinoma

    • Fabiola Cecchi, Young H. Lee, Benedetta Peruzzi, Jean-Baptiste Lattouf, Donald P. Bottaro
    Pages 303-318
  12. Development of Resistance to Targeted Therapy: Preclinical Findings and Clinical Relevance

    • James W. Mier, Rupal S. Bhatt, David J. Panka, Michael B. Atkins
    Pages 319-348
  13. Development of Combination Therapy with Targeted Agents

    • C. Lance Cowey, Thomas E. Hutson
    Pages 349-375
  14. Side Effects of Targeted Therapy

    • Luis León, Luis Miguel Antón-Aparicio, Emilio Esteban-González, Martin Lázaro-Quintela, Sergio Vázquez-Éstevez
    Pages 377-416
  15. The Role of Targeted Therapy in Special Populations

    • James M. G. Larkin, Martin E. Gore
    Pages 417-439

About this book

​​

​The third edition of this critically acclaimed book has updated and expanded the survey of clinical, biological and pathological management of localized and advanced renal cell carcinoma. Internationally renowned editors and contributors explore the latest developments in molecular genetics, focusing on the novel targets that have been discovered in epithelial renal tumors.

Comprehensive and authoritative, Renal Cell Carcinoma: Molecular Targets and Clinical Applications, Third Edition is the definitive text on the rapidly evolving landscape of experimental therapeutics, written and edited by leaders of the field.​

Reviews

From the book reviews:

“This is an important reference for practicing medical oncologists, urologists, and researchers interested in the biology and therapy of this disease. … This book details the most recent research into the molecular targets of RCC and applications for clinical drug development. … It should be part of libraries for clinicians or basic scientists dealing with RCC. It certainly is an excellent reference for basic and translational scientists and clinicians in this field.” (Jianqing Lin, Doody’s Book Reviews, February, 2015)

Editors and Affiliations

  • Taussig Cancer Center, Cleveland Clinic, Pepper Pike, USA

    Ronald M. Bukowski

  • Division of Hematology Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA

    Robert A. Figlin

  • Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA

    Robert J. Motzer

About the editors

Ronald M Bukowski MD
Emeritus Staff Physician
Cleveland Clinic Taussig Cancer Center
Professor Emeritus of Medicine
CCF Lerner College of Medicine of CWRU

Robert Figlin MD
Professor of Medicine and Biomedical Sciences
Director, Division of Hematology Oncology
Department of Medicine, Cedars-Sinai Medical Center
Associate Director for Academic Programs
Samuel Oschin Comprehensive Cancer Institute
Professor Emeritus of Medicine and Urology
David Geffen School of Medicine at UCLA

Robert Motzer MD
Attending Physician
Department of Medicine
Memorial Sloan-Kettering Cancer Center
Professor of Medicine
Weil Medical College of Cornell University

Bibliographic Information

  • Book Title: Renal Cell Carcinoma

  • Book Subtitle: Molecular Targets and Clinical Applications

  • Editors: Ronald M. Bukowski, Robert A. Figlin, Robert J. Motzer

  • DOI: https://doi.org/10.1007/978-1-4939-1622-1

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-1621-4Published: 27 November 2014

  • Softcover ISBN: 978-1-4939-5063-8Published: 23 August 2016

  • eBook ISBN: 978-1-4939-1622-1Published: 27 November 2014

  • Edition Number: 3

  • Number of Pages: XVIII, 613

  • Number of Illustrations: 9 b/w illustrations, 41 illustrations in colour

  • Topics: Oncology, Nuclear Medicine

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access