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Neurosteroids pp 317–335Cite as

Neurosteroids

Behavioral Studies

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Part of the book series: Contemporary Endocrinology ((COE,volume 16))

Abstract

The reports of higher concentrations of certain steroids in the brain than in blood and of their accumulation in brain independently of adrenal and gonadal sources led to the discovery of steroid biosynthetic pathways in the central nervous system (CNS). As a result, the term “neurosteroids” was proposed, referring to steroids synthesized in the brain, either de novo from cholesterol or by in situ metabolism of blood-borne precursors (1). In this chapter, we summarize the behavioral effects—on affective and cognitive functions—of systemic or intra-cerebral administration of these neurosteroids. In addition to these pharmacological studies, we focus on recent physiological data indicating a possible role of certain neurosteroids in age-related memory deficits. Neurosteroids and affective responses: anxiety, stress, and aggression

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Authors
  1. Willy Mayo MD
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  2. Monique Vallée MD
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  3. Muriel Darnaudéry MD
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  4. Michel Le Moal MD
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Editors and Affiliations

  1. Institut National de la Santé et de la Recherche Médicale, Collége de France, Le Kremlin-Bicêtre, France

    Etienne-Emile Baulieu MD, PhD , Paul Robel MD, PhD  & Michael Schumacher PhD ,  & 

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Mayo, W., Vallée, M., Darnaudéry, M., Moal, M.L. (1999). Neurosteroids. In: Baulieu, EE., Robel, P., Schumacher, M. (eds) Neurosteroids. Contemporary Endocrinology, vol 16. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-693-5_18

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  • DOI: https://doi.org/10.1007/978-1-59259-693-5_18

  • Publisher Name: Humana Press, Totowa, NJ

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