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Rat Genomics pp 357–388Cite as

Rat Genomics Applied to Psychiatric Research

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 597))

Abstract

Psychiatric diseases are very debilitating and some of them highly prevalent (e.g., depression or anxiety). The rat remains one model of choice in this discipline to investigate the neural mechanisms underlying normal and pathological traits. Genomic tools are now applied to identify genes involved in psychiatric illnesses and also to provide new biomarkers for diagnostic and prognosis, new targets for treatment and more generally to better understand the functioning of the brain. In this report, we will review rat models, behavioral approaches used to model psychiatry-related traits and the major studies published in the field including genetic mapping of quantitative trait loci (QTL), transcriptomics, proteomics and transgenic models.

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Authors and Affiliations

  1. INRA, UMR 1286 PsyNuGen, CNRS, UMR 5226, Université de Bordeaux 2, Bordeaux, France

    Marie-Pierre Moisan

  2. Lab Genética do Comportamento, Departamento de Biologia Celular, Embriologia e Genética, CCB, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil

    André Ramos

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  1. Marie-Pierre Moisan
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  2. André Ramos
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Correspondence to Marie-Pierre Moisan .

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Editors and Affiliations

  1. ITERT-INSERM U643, CHU de Nantes, bd. Jean Monnet 30, Nantes, 44093, France

    Ignacio Anegon

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Moisan, MP., Ramos, A. (2010). Rat Genomics Applied to Psychiatric Research. In: Anegon, I. (eds) Rat Genomics. Methods in Molecular Biology, vol 597. Humana Press. https://doi.org/10.1007/978-1-60327-389-3_25

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  • DOI: https://doi.org/10.1007/978-1-60327-389-3_25

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