Abstract
Neurodegenerative diseases, such as Parkinson’s disease (PD), offer unique opportunities for the therapeutic application of viral vector gene transfer. In this chapter, we discuss the current state of viral vector preclinical development in nonhuman primate with special focus on vectors derived from adeno-associated virus (AAV) and lentivirus (LV), as they are the only ones that have reached clinical trials. We also outline desired features for improving the routes of delivery, tropism specificity, and other parameters that influence achievement of successful therapeutic goals.
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Abbreviations
- 6-OHDA:
-
6-Hydroxydopamine
- AADC:
-
Aromatic l-amino acid decarboxylase
- AAV:
-
Adeno-associated virus
- CNS:
-
Central nervous system
- D1:
-
Dopamine D1 receptors
- D2:
-
Dopamine D2 receptors
- GABA:
-
γ-Aminobutyric acid
- GAD:
-
Glutamic acid decarboxylase
- GCH:
-
Guanosine triphosphate cyclohydrolase I
- GDNF:
-
Glial cell line-derived neurotrophic factor
- GRKs:
-
G protein coupled receptor
- GTPase:
-
Guanosine triphosphatase
- l-DOPA:
-
l-3,4-Dihydroxyphenylalanine
- LID:
-
l-DOPA-induced dyskinesia
- LV:
-
Lentivirus
- MPTP:
-
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- MRI:
-
Magnetic resonance image
- NPH:
-
Nonhuman primate
- PD:
-
Parkinson’s disease
- SN:
-
Substantia nigra
- STN:
-
Subthalamic nucleus
- TH:
-
Tyrosine hydroxylase
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Porras, G., Dehay, B., Bezard, E. (2014). Viral Vectors in Primate Research: Examples from Parkinson’s Disease Research. In: Brambilla, R. (eds) Viral Vector Approaches in Neurobiology and Brain Diseases. Neuromethods, vol 82. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-610-8_17
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DOI: https://doi.org/10.1007/978-1-62703-610-8_17
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