Abstract
The use of biotechnologies has dramatically increased in recent years, radically changing our relationship with animals and their use in several fields, from food industry to scientific research. Provided here is an overview of those biotechnologies having the most relevant impact on our approach to animals, and a discussion of their implications in bioethical terms as well as their scientific and general advantages versus their limitations. This chapter concentrates on biotechnologies applied to biomedical science, providing a large range of examples particularly focused on genetic modifications of laboratory animals.
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References
Airan, R.D., E.S. Hu, R. Vijaykumar, M. Roy, L.A. Meltzer, and K. Deisseroth. 2007. Integration of Light-controlled Neuronal Firing and Fast Circuit Imaging. Curr Opin Neurobiol 17 (5): 587–592. https://doi.org/10.1016/j.conb.2007.11.003.
Aravanis, A.M., L.P. Wang, F. Zhang, L.A. Meltzer, M.Z. Mogri, M.B. Schneider, and K. Deisseroth. 2007. An Optical Neural Interface: In Vivo Control of Rodent Motor Cortex with Integrated Fiberoptic and Optogenetic Technology. J Neural Eng 4 (3): S143–S156. https://doi.org/10.1088/1741-2560/4/3/S02.
Arenkiel, B.R., J. Peca, I.G. Davison, C. Feliciano, K. Deisseroth, G.J. Augustine, M.D. Ehlers, and G. Feng. 2007. In Vivo Light-induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2. Neuron 54 (2): 205–218. https://doi.org/10.1016/j.neuron.2007.03.005.
Barnard, C. 2007. Ethical Regulation and Animal Science: Why Animal Behaviour Is Special. Anim Behav 74: 5–13. https://doi.org/10.1136/vr.160.8.275-a.
Bignami, G. 1965. Selection for High Rates and Low Rates of Avoidance Conditioning in the Rat. Anim Behav 13 (2): 221–227.
Blakemore, C., J. MaCarthur Clark, T. Nevalainen, M. Oberdorfer, and A. Sussman. 2012. Implementing the 3Rs in Neuroscience Research: A Reasoned Approach. Neuron 75 (6): 948–950. https://doi.org/10.1016/j.neuron.2012.09.001.
Bovenkerk, B., and F. Kaldewaij. 2015. The Use of Animal Models in Behavioural Neuroscience Research. Curr Top Behav Neurosci 19: 17–46. https://doi.org/10.1007/7854_2014_329.
Branchi, I. 2009. The Mouse Communal Nest: Investigating the Epigenetic Influences of the Early Social Environment on Brain and Behavior Development. Neurosci Biobehav Rev 33 (4): 551–559.
Branchi, I., and L. Ricceri. 2002. Transgenic and Knock-out Mouse Pups: The Growing Need for Behavioral Analysis. Genes Brain Behav 1 (3): 135–141.
Broadhurst, P.L., and G. Bignami. 1965. Correlative Effects of Psychogenetic Selection: A Study of the Roman High and Low Avoidance Strains of Rats. Behav Res Ther 3: 273–280. https://doi.org/10.1016/0005-7967(64)90033-6.
Burman, O.H.P., and M.T. Mendl. 2018. A Novel Task to Assess Mood Congruent Memory Bias in Non-human Animals. J Neurosci Methods 308: 269–275. https://doi.org/10.1016/j.jneumeth.2018.07.003.
Capecchi, M. 1990. Gene Targeting: Tapping the Cellular Telephone. Nature 344 (6262): 105. https://doi.org/10.1038/344105a0.
Capecchi, M.R. 1989. The New Mouse Genetics: Altering the Genome by Gene Targeting. Trends Genet 5 (3): 70–76. https://doi.org/10.1016/0168-9525(89)90029-2.
———. 2000. How Close Are We to Implementing Gene Targeting in Animals Other Than the Mouse? Proc Natl Acad Sci U S A 97 (3): 956–957. https://doi.org/10.1073/pnas.97.3.956.
Cases, O., I. Seif, J. Grimsby, P. Gaspar, K. Chen, S. Pournin, U. Muller, M. Aguet, C. Babinet, J.C. Shih, et al. 1995. Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA. Science 268 (5218): 1763–1766. https://doi.org/10.1126/science.7792602.
Cassaday, H.J. 2015. What's Special About the Ethical Challenges of Studying Disorders with Altered Brain Activity? Curr Top Behav Neurosci 19: 137–157. https://doi.org/10.1007/7854_2014_333.
Ciliberti, R., and A. Molinelli. 2005. Towards an GMO Discipline: Ethical Remarks. Veterinary Research Communications 29: 27–30. https://doi.org/10.1007/s11259-005-0006-4.
Crawley, J.N. 1999. Behavioral Phenotyping of transgenic and Knockout Mice: Experimental Design and Evaluation of General Health, Sensory Functions, Motor Abilities, and Specific Behavioral Tests. Brain Res 835 (1): 18–26.
———. 2007. What's Wrong with My Mouse? 2nd ed. London: Wiley.
Crusio, W.E. 1996. Gene-targeting Studies: New Methods, Old Problems. Trends Neurosci 19 (5): 186–187. discussion 188-9.
———. 2004. Flanking Gene and Genetic Background Problems in Genetically Manipulated Mice. Biol Psychiatry 56 (6): 381–385.
Crusio, W.E., D. Goldowitz, A. Holmes, and D. Wolfer. 2009. Standards for the Publication of Mouse Mutant Studies. Genes, Brain and Behavior 8 (1): 1–4.
Darwin, C. 1859. On the Origin of Species by Means of Natural Selection, or, the Preservation of Favoured Races in the Struggle for Life. London: J. Murray.
de Castro, A.C.V., and I.A.S. Olsson. 2015. Does the Goal Justify the Methods? Harm and Benefit in Neuroscience Research Using Animals. Ethical Issues in Behavioral Neuroscience 19: 47–78. https://doi.org/10.1007/7854_2014_319.
Driscoll, P., R.M. Escorihuela, A. Fernandez-Teruel, O. Giorgi, H. Schwegler, T. Steimer, A. Wiersma, M.G. Corda, J. Flint, J.M. Koolhaas, W. Langhans, P.E. Schulz, J. Siegel, and A. Tobena. 1998. Genetic Selection and Differential Stress Responses - The Roman lines/strains of rats. Stress of Life 851: 501–510. https://doi.org/10.1111/j.1749-6632.1998.tb09029.x.
Driscoll, P., A. Fernandez-Teruel, M.G. Corda, O. Giorgi, and T. Steimer. 2010. Some Guidelines for Defining Personality Differences in Rats. Handbook of Behavior Genetics 1: 281–300. https://doi.org/10.1007/978-0-387-76727-7_20.
Edmunds, T., S.M. Van Patten, J. Pollock, E. Hanson, R. Bernasconi, E. Higgins, P. Manavalan, C. Ziomek, H. Meade, J.M. McPherson, and E.S. Cole. 1998. Transgenically Produced Human Antithrombin: Structural and Functional Comparison to Human Plasma-derived Antithrombin. Blood 91 (12): 4561–4571.
Food Safety Departement, World Health Organization. 2005. Modern Food Biotechnology, Human Health and Development: An Evidence-Based Study. Geneva.
Garas, L.C., J.D. Murray, and E.A. Maga. 2015. Genetically Engineered Livestock: Ethical Use for Food and Medical Models. Annu Rev Anim Biosci 3: 559–575. https://doi.org/10.1146/annurev-animal-022114-110739.
Giorgi, O., G. Piras, A. Fernandez-Teruel, T. Steimer, and P. Driscoll. 2007. Some Guidelines for Defining Personality Differences in Rats: Focus on the Roman Lines as a MModel for Studying the Influence of the Genetic Background on the Individual Vulnerability to Drug Addiction. Behavior Genetics 37 (6): 756–757.
Gosling, S.D. 2001. From Mice to Men: What Can We Learn About Personality from Animal Research? Psychol Bull 127 (1): 45–86. https://doi.org/10.1037/0033-2909.127.1.45.
Gradinaru, V., K.R. Thompson, F. Zhang, M. Mogri, K. Kay, M.B. Schneider, and K. Deisseroth. 2007. Targeting and Readout Strategies for Fast Optical Neural Control in vitro and in vivo. J Neurosci 27 (52): 14231–14238. https://doi.org/10.1523/JNEUROSCI.3578-07.2007.
Grandin, T. 2005. Animals in Translation : Using the Mysteries of Autism to Decode Animal Behavior. New York: Scribner.
Grisolia, C.K. 2005. Genes, Genome and Gestalt. Genetics and Molecular Research 4 (1): 100–104.
Han, W., L.A. Tellez, M.J. Rangel Jr., S.C. Motta, X. Zhang, I.O. Perez, N.S. Canteras, S.J. Shammah-Lagnado, A.N. van den Pol, and I.E. de Araujo. 2017. Integrated Control of Predatory Hunting by the Central Nucleus of the Amygdala. Cell 168 (1-2): 311–324. e18. https://doi.org/10.1016/j.cell.2016.12.027.
Hoeyer, K., and L. Koch. 2006. The Ethics of Functional Genomics: Same, Same, But Different? Trends Biotechnol 24 (9): 387–389. https://doi.org/10.1016/j.tibtech.2006.06.011.
Hug, K. 2008. Genetically Modified Organisms: Do the Benefits Outweigh the Risks? Medicina-Lithuania 44 (2): 87–99. https://doi.org/10.3390/medicina44020012.
Kohl, P.A., D. Brossard, D.A. Scheufele, and M.A. Xenos. 2019. Public Views About Editing Genes in Wildlife for Conservation. Conserv Biol 33 (6): 1286–1295. https://doi.org/10.1111/cobi.13310.
Koolhaas, J.M. 2008. Coping Style and Immunity in Animals: Making Sense of Individual Variation. Brain Behav Immun 22 (5): 662–667. https://doi.org/10.1016/j.bbi.2007.11.006.
Kumar, T.R., M. Larson, H. Wang, J. McDermott, and I. Bronshteyn. 2009. Transgenic Mouse Technology: Principles and Methods. Methods Mol Biol 590: 335–362. https://doi.org/10.1007/978-1-60327-378-7_22.
Lassen, J., M. Gjerris, and P. Sandoe. 2006. After Dolly - Ethical limits to the use of Biotechnology on Farm Animals. Theriogenology 65 (5): 992–1004. https://doi.org/10.1016/j.theriogenology.2005.09.012.
Lee, K. 2001. Can Cloning Save Endangered Species? Curr Biol 11 (7): R245–R246. https://doi.org/10.1016/s0960-9822(01)00126-9.
Lund, T.B., T.I. Sorensen, I.A. Olsson, A.K. Hansen, and P. Sandoe. 2014. Is It Acceptable to Use Animals to Model Obese Humans? A Critical Discussion of Two Arguments Against the Use of Animals in Obesity Research. J Med Ethics 40 (5): 320–324. https://doi.org/10.1136/medethics-2011-100368.
Macnaghten, P. 2004. Animals in Their Nature: A Case Study on Public Attitudes to Animals, Genetic Modification and 'Nature'. Sociology-the Journal of the British Sociological Association 38 (3): 533–551. https://doi.org/10.1177/0038038504043217.
Matsumiya, L.C., R.E. Sorge, S.G. Sotocinal, J.M. Tabaka, J.S. Wieskopf, A. Zaloum, O.D. King, and J.S. Mogil. 2012. Using the Mouse Grimace Scale to Reevaluate the Efficacy of Postoperative Analgesics in Laboratory Mice. J Am Assoc Lab Anim Sci 51 (1): 42–49.
Mcewen, B.S., and E. Stellar. 1993. Stress and the Individual - Mechanisms Leading to Disease. Archives of Internal Medicine 153 (18): 2093–2101. https://doi.org/10.1001/archinte.153.18.2093.
Mogil, J.S., D.S.J. Pang, G.G. Silva Dutra, and C.T. Chambers. 2020. The Development and Use of Facial Grimace Scales for Pain Measurement in Animals. Neurosci Biobehav Rev 116: 480–493. https://doi.org/10.1016/j.neubiorev.2020.07.013.
Nicholas, F.W., C.M. Wade, and P. Williamson. 2010. Disorders in Pedigree Dogs: Assembling the Evidence. Vet J 183 (1): 8–9. https://doi.org/10.1016/j.tvjl.2009.11.008.
Oddi, D., E. Subashi, S. Middei, L. Bellocchio, V. Lemaire-Mayo, M. Guzman, W.E. Crusio, F.R. D'Amato, and S. Pietropaolo. 2015. Early Social Enrichment Rescues Adult Behavioral and Brain Abnormalities in a Mouse Model of Fragile X Syndrome. Neuropsychopharmacology 40 (5): 1113–1122. https://doi.org/10.1038/npp.2014.291.
Ohl, F., and F.J. van der Staay. 2012. Animal Welfare: At the Interface Between Science and Society. Vet J 192 (1): 13–19. https://doi.org/10.1016/j.tvjl.2011.05.019.
Ortiz, Sara Elizabeth Gavrell. 2004. Beyond Welfare: Animal Integrity, Animal Dignity, and Genetic Engineering. Ethics & the Environment 9: 120–194.
Paul, E.S., S. Sher, M. Tamietto, P. Winkielman, and M.T. Mendl. 2020. Towards a Comparative Science of Emotion: Affect and Consciousness in Humans and Animals. Neurosci Biobehav Rev 108: 749–770. https://doi.org/10.1016/j.neubiorev.2019.11.014.
Ramsoondar, J.J., Z. Machaty, C. Costa, B.L. Williams, W.L. Fodor, and K.R. Bondioli. 2003. Production of Alpha 1,3-Galactosyltransferase-knockout Cloned Pigs Expressing Human alpha 1,2-fucosylosyltransferase. Biol Reprod 69 (2): 437–445. https://doi.org/10.1095/biolreprod.102.014647.
Rapp, J.C., A.J. Harvey, G.L. Speksnijder, W. Hu, and R. Ivarie. 2003. Biologically Active Human Interferon Alpha-2b Produced in the egg White of Transgenic Hens. Transgenic Res 12 (5): 569–575. https://doi.org/10.1023/a:1025854217349.
Redford, K.H., W. Adams, and G.M. Mace. 2013. Synthetic Biology and Conservation of Nature: Wicked Problems and Wicked Solutions. PLoS Biol 11 (4): e1001530. https://doi.org/10.1371/journal.pbio.1001530.
Redmalm, D. 2014. Holy Bonsai Wolves: Chihuahuas and the Paris Hilton syndrome. International Journal of Cultural Studies 17 (1): 93–109. https://doi.org/10.1177/1367877912464539.
Regan, T. 1984. The Case for Animal Rights. London: Routledge.
Rollin, B.E. 2003. On Telos and Genetic Engineering. In Animal Ethics Reader, ed. S.J. Armstrong and R.G. Botzler, 342–350. London: Routledge.
Russell, W.M.S. 1959. The Principles of Humane Experimental Technique. London: Methuen.
Ryder, R. 1975. Victims of Science: The Use of Animals in Research. London: Open Gate Press.
Sandoe, P., S.V. Kondrup, P.C. Bennett, B. Forkman, I. Meyer, H.F. Proschowsky, J.A. Serpell, and T.B. Lund. 2017. Why Do People Buy Dogs with Potential Welfare Problems Related to Extreme Conformation and Inherited Disease? A Representative Study of Danish Owners of Four Small Dog Breeds. Plos One 12 (2): 1. ARTN e017209110.1371/journal.pone.0172091.
Schicktanz, S. 2006. Ethical Considerations of the Human-animal-relationship Under Conditions of Asymmetry and Ambivalence. Journal of Agricultural & Environmental Ethics 19 (1): 7–16. https://doi.org/10.1007/s10806-005-4374-0.
Schuppli, C.A., and D.M. Weary. 2010. Attitudes Towards the Use of Genetically Modified Animals in Research. Public Understanding of Science 19 (6): 686–697. https://doi.org/10.1177/0963662510362834.
Sotocinal, S.G., R.E. Sorge, A. Zaloum, A.H. Tuttle, L.J. Martin, J.S. Wieskopf, J.C. Mapplebeck, P. Wei, S. Zhan, S. Zhang, J.J. McDougall, O.D. King, and J.S. Mogil. 2011. The Rat Grimace Scale: A Partially Automated Method for Quantifying Pain in the Laboratory Rat Via Facial Expressions. Mol Pain 7: 55. https://doi.org/10.1186/1744-8069-7-55.
Steimer, T., and P. Driscoll. 2003. Divergent Stress Responses and Coping Styles in Psychogenetically Selected Roman high-(RHA) and low-(RLA) avoidance rats: Behavioural, neuroendocrine and developmental aspects. Stress-the International Journal on the Biology of Stress 6 (2): 87–100. https://doi.org/10.1080/1025389031000111320.
———. 2005. Inter-individual vs line/strain Differences in Psychogenetically Selected Roman High-(RHA) and Low-(RLA) Avoidance Rats: Neuroendocrine and Behavioural Aspects. Neuroscience and Biobehavioral Reviews 29 (1): 99–112. https://doi.org/10.1016/j.neubiorev.2004.07.002.
Steimer, T., R.M. Escorihuela, A. Fernandez-Teruel, and P. Driscoll. 1998. Long-term Behavioural and Neuroendocrine Changes in Roman high-(RHA/Verh) and low-(RLA-Verh) Avoidance Rats Following Neonatal Handling. International Journal of Developmental Neuroscience 16 (3-4): 165–174. https://doi.org/10.1016/S0736-5748(98)00032-X.
Thomas, K.R., and M.R. Capecchi. 1987. Site-directed Mutagenesis by Gene Targeting in Mouse Embryo-derived Stem Cells. Cell 51 (3): 503–512. https://doi.org/10.1016/0092-8674(87)90646-5.
Thomas, M.A., G.W. Roemer, C.J. Donlan, B.G. Dickson, M. Matocq, and J. Malaney. 2013. Ecology: Gene Tweaking for Conservation. Nature 501 (7468): 485–486. https://doi.org/10.1038/501485a.
Trimmer, P.C., E.S. Paul, M.T. Mendl, J.M. McNamara, and A.I. Houston. 2013. On the Evolution and Optimality of Mood States. Behav Sci (Basel) 3 (3): 501–521. https://doi.org/10.3390/bs3030501.
Vegas, O., E. Fano, P.F. Brain, A. Alonso, and A. Azpiroz. 2006. Social Stress, Coping Strategies and Tumor Development in Male Mice: Behavioral, Neuroendocrine and Immunological Implications. Psychoneuroendocrinology 31 (1): 69–79. https://doi.org/10.1016/j.psyneuen.2005.05.013.
Verhoog, H. 1992. The Concept of Intrinsic Value and Transgenic Animals. J Agric Ethics 5 (2): 147–160. https://doi.org/10.1007/BF01966357.
Vesikansa, A. 2018. Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation. J Cent Nerv Syst Dis 10: 1179573518787469. https://doi.org/10.1177/1179573518787469.
Wurbel, H. 2009. Ethology Applied to Animal ethics. Appl Anim Behav Sci 118: 118–127. https://doi.org/10.1016/j.bbr.2009.05.001.
Yizhar, O., L.E. Fenno, M. Prigge, F. Schneider, T.J. Davidson, D.J. O'Shea, V.S. Sohal, I. Goshen, J. Finkelstein, J.T. Paz, K. Stehfest, R. Fudim, C. Ramakrishnan, J.R. Huguenard, P. Hegemann, and K. Deisseroth. 2011. Neocortical Excitation/inhibition Balance in Information Processing and Social Dysfunction. Nature 477 (7363): 171–178. https://doi.org/10.1038/nature10360.
Zhang, F., J. Vierock, O. Yizhar, L.E. Fenno, S. Tsunoda, A. Kianianmomeni, M. Prigge, A. Berndt, J. Cushman, J. Polle, J. Magnuson, P. Hegemann, and K. Deisseroth. 2011. The Microbial Opsin Family of Optogenetic Tools. Cell 147 (7): 1446–1457. https://doi.org/10.1016/j.cell.2011.12.004.
Zhu, L., M.C. van de Lavoir, J. Albanese, D.O. Beenhouwer, P.M. Cardarelli, S. Cuison, D.F. Deng, S. Deshpande, J.H. Diamond, L. Green, E.L. Halk, B.S. Heyer, R.M. Kay, A. Kerchner, P.A. Leighton, C.M. Mather, S.L. Morrison, Z.L. Nikolov, D.B. Passmore, A. Pradas-Monne, B.T. Preston, V.S. Rangan, M. Shi, M. Srinivasan, S.G. White, P. Winters-Digiacinto, S. Wong, W. Zhou, and R.J. Etches. 2005. Production of Human Monoclonal Antibody in Eggs of Chimeric Chickens. Nat Biotechnol 23 (9): 1159–1169. https://doi.org/10.1038/nbt1132.
Acknowledgements
S. Pietropaolo received funding from CNRS and Bordeaux University; her research on mouse models of human neuropathologies is funded by the Association “Autour de Williams” and the “Fondation Pour l’Audition (FPA RD-2020-8)”.
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Pietropaolo, S. (2022). Biotechnologies and Animals: The Impact of Genetic Engineering on Human-Animal Relationships. In: Vitale, A., Pollo, S. (eds) Human/Animal Relationships in Transformation. The Palgrave Macmillan Animal Ethics Series. Palgrave Macmillan, Cham. https://doi.org/10.1007/978-3-030-85277-1_12
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