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Role of Serotonin2A (5-HT2A) Receptors in Epilepsy

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5-HT2A Receptors in the Central Nervous System

Part of the book series: The Receptors ((REC,volume 32))

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Abstract

5-Hydroxytryptamine 2A receptors (5-HT2ARs), have been implicated in various psychiatric and neurological disorders, including epilepsy. Interestingly, epileptic patients commonly present comorbid psychiatric symptoms, and a bidirectional link between depression and epilepsy has been suggested. Therefore, the alteration of 5-HT2A signalling might represent a common anatomical and neurobiological substrate of both pathologies.

After a brief presentation of the role of 5-HT in epilepsy, this chapter illustrates how 5-HT2A receptors may directly or indirectly control neuronal excitability in networks involved in different types of epilepsy. It also synthetizes the preclinical and clinical evidence, demonstrating the role of these receptors in antiepileptic responses.

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Abbreviations

5-HT:

5-hydroxytryptamine or serotonin

5-HT2A-Rs:

Serotonin 2A receptors

AD:

After discharge

DA:

Dopamine

DG:

Dentate gyrus

DOI:

2,5-Dimethoxy-4-iodoamphetamine

DRN:

Dorsal raphe nucleus

eGABA:

Extrasynaptic GABAA

GAERS:

Genetic absence epilepsy in rats from Strasbourg

GPCRs:

G protein coupled receptors

LC:

Locus coeruleus

MDA:

Maximal dentate activation

mPFC:

Medial prefrontal cortex

MRN:

Medial raphe nucleus

NE:

Norepinephrine

NRT:

Nucleus reticulari thalami

PAG:

Periaqueductal grey

SERT:

Serotonin transporter

SSRI:

Selective serotonin reuptake inhibitor

SUDEP:

Sudden unexpected death in epilepsy

SWDs:

Spike and wave discharges

VB:

Ventrobasal thalamus

VTA:

Ventral tegmental area

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Acknowledgments

Our work in this area was supported by the ERUK (grant P1202 to VC and GDG), the Malta Council of Science and Technology (grant R&I-2013-14 to GDG and VC) and EU COST Action CM1103 (GDG and PDD).

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Authors and Affiliations

  1. Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK

    Vincenzo Crunelli & Giuseppe Di Giovanni

  2. Department of Physiology and Biochemistry, University of Malta, Msida, Malta

    Vincenzo Crunelli & Giuseppe Di Giovanni

  3. AstraZeneca Translational Science Centre at Karolinska Institutet, Stockholm, Sweden

    Marcello Venzi

  4. Université de Bordeaux, Bordeaux, France

    Philippe De Deurwaerdère

  5. Centre National de la Recherche Scientifique, UMR 5287, Bordeaux, France

    Philippe De Deurwaerdère

Authors
  1. Vincenzo Crunelli
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  2. Marcello Venzi
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  3. Philippe De Deurwaerdère
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  4. Giuseppe Di Giovanni
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Corresponding authors

Correspondence to Vincenzo Crunelli or Giuseppe Di Giovanni .

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Editors and Affiliations

  1. Faculté de Pharmacie, Université Paris Sud, Université Paris-Saclay, Chatenay-Malabry, France

    Bruno P. Guiard

  2. Department of Physiology and Biochemistry, University of Malta, Msida MSD, Malta

    Giuseppe Di Giovanni

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Crunelli, V., Venzi, M., De Deurwaerdère, P., Di Giovanni, G. (2018). Role of Serotonin2A (5-HT2A) Receptors in Epilepsy. In: Guiard, B., Di Giovanni, G. (eds) 5-HT2A Receptors in the Central Nervous System. The Receptors, vol 32. Humana Press, Cham. https://doi.org/10.1007/978-3-319-70474-6_16

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