Abstract
Tractography allows the investigation of white matter fascicles. However, it requires a large amount of streamlines to be generated to cover the full spatial extent of desired bundles. In this work, a bundle-specific tractography algorithm was developed to increase reproducibility and sensitivity of white matter fascicle virtual dissection, thus avoiding the computation of a full brain tractography. Using fascicle priors from manually segmented bundles templates or atlases, we propose a novel local orientation enhancement methodology that overcomes reconstruction difficulties in crossing regions. To reduce unnecessary computation, tractography seeding and tracking were restricted to specific locales within the brain. These additions yield better spatial coverage, increasing the quality of the fanning in crossing regions, helping to accurately represent fascicle shape. In this work, tractography methods were analyzed and compared using a single bundle of interest, the corticospinal tract.
Francois Rheault and Etienne St-Onge contributed equally to this manuscript.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Assaf, Y., Pasternak, O.: Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. J. Mol. Neurosci. 34(1), 51–61 (2008). https://doi.org/10.1007/s12031-007-0029-0
Avants, B., Epstein, C., Grossman, M., Gee, J.: Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain. Med. Image Anal. 12(1), 26–41 (2008)
Behrens, T.E., Berg, H.J., Jbabdi, S., Rushworth, M., Woolrich, M.: Probabilistic diffusion tractography with multiple fibre orientations: what can we gain? NeuroImage 34(1), 144–155 (2007)
Catani, M., De Schotten, M.T.: A diffusion tensor imaging tractography atlas for virtual in vivo dissections. Cortex 44(8), 1105–1132 (2008)
Catani, M., Howard, R.J., Pajevic, S., Jones, D.K.: Virtual in vivo interactive dissection of white matter fasciculi in the human brain. NeuroImage 17, 77–94 (2002)
Chamberland, M., Whittingstall, K., Fortin, D., Mathieu, D., Descoteaux, M.: Real-time multi-peak tractography for instantaneous connectivity display. Front. Neuroinform. 8, 59 (2014)
Chamberland, M., Scherrer, B., Prabhu, S.P., Madsen, J., Fortin, D., Whittingstall, K., Descoteaux, M., Warfield, S.K.: Active delineation of Meyer’s loop using oriented priors through magnetic tractography (magnet). Hum. Brain Mapp. 38(1), 509–527 (2017)
Cousineau, M., Jodoin, P.M., Garyfallidis, E., Côté, M.A., Morency, F.C., Rozanski, V., Grand’Maison, M., Bedell, B.J., Descoteaux, M.: A test–retest study on parkinson’s ppmi dataset yields statistically significant white matter fascicles. NeuroImage: Clinical 16(Suppl. C), 222–233 (2017). http://www.sciencedirect.com/science/article/pii/S2213158217301869
Dayan, M., Monohan, E., Pandya, S., Kuceyeski, A., Nguyen, T.D., Raj, A., Gauthier, S.A.: Profilometry: a new statistical framework for the characterization of white matter pathways, with application to multiple sclerosis. Hum. Brain Mapp. 37(3), 989–1004 (2015). https://doi.org/10.1002/hbm.23082
Descoteaux, M., Deriche, R., Knosche, T.R., Anwander, A.: Deterministic and probabilistic tractography based on complex fibre orientation distributions. IEEE Trans. Med. Imaging 28(2), 269–286 (2009)
Desikan, R.S., Ségonne, F., Fischl, B., Quinn, B.T., Dickerson, B.C., Blacker, D., Buckner, R.L., Dale, A.M., Maguire, R.P., Hyman, B.T., et al.: An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31(3), 968–980 (2006)
Dhollander, T., Emsell, L., Hecke, W.V., Maes, F., Sunaert, S., Suetens, P.: Track orientation density imaging (TODI) and track orientation distribution (TOD) based tractography. NeuroImage 94, 312–336 (2014)
Dubois, J., Dehaene-Lambertz, G., Perrin, M., Mangin, J., Cointepas, Y., Duchesnay, E., Bihan, D.L., Hertz-Pannier, L.: Asynchrony of the early maturation of white matter bundles in healthy infants: quantitative landmarks revealed noninvasively by diffusion tensor imaging. Hum. Brain Mapp. 29(1), 14–27 (2008). https://doi.org/10.1002/hbm.20363
Girard, G., Descoteaux, M.: Anatomical tissue probability priors for tractography. In: International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI’12)-Computational Diffusion MRI Workshop, pp. 174–185 (2012)
Girard, G., Descoteaux, M.: Towards quantitative connectivity analysis: reducing tractography biases. NeuroImage 98(1), 266–278 (2014)
Jbabdi, S., Johansen-Berg, H.: Tractography: where do we go from here? Brain connect. 1(3), 169–183 (2011)
Mazoyer, B., Mellet, E., Perchey, G., Zago, L., Crivello, F., Jobard, G., Delcroix, N., Vigneau, M., Leroux, G., Petit, L., Joliot, M., Tzourio-Mazoyer, N.: BIL&GIN: a neuroimaging, cognitive, behavioral, and genetic database for the study of human brain lateralization. NeuroImage 124 Part B, 1225–1231 (2016)
Smith, R.E., Tournier, J.D., Calamante, F., Connelly, A.: Anatomically-constrained tractography: improved diffusion MRI streamlines tractography through effective use of anatomical information. NeuroImage 62(3), 1924–1938 (2012)
Takemura, H., Caiafa, C.F., Wandell, B.A., Pestilli, F.: Ensemble tractography. PLOS Comput. Biol. 12(2), 1–22 (2016)
Tournier, J.D., Cho, K.H., Calamante, F., Yeh, C.H., Connelly, A., Lin, C.P.: Resolving crossing fibres using constrained spherical deconvolution: Validation using DWI phantom data. In: Proceedings of the International Society of Magnetic Resonance in Medicine, Berlin, p. 902 (2007)
Tournier, J.D., Calamante, F., Connelly, A.: MRtrix: diffusion tractography in crossing fiber regions. Int. J. Imaging Syst. Technol. 22(1), 53–66 (2012)
Wang, R., Benner, T., Sorensen, A., Wedeen., V.: Diffusion toolkit: a software package for diffusion imaging data processing and tractography. In: International Symposium on Magnetic Resonance in Medicine (ISMRM’07), p. 3720 (2007)
Wassermann, D., Makris, N., Rathi, Y., Shenton, M., Kikinis, R., Kubicki, M., Westin, C.F.: The white matter query language: a novel approach for describing human white matter anatomy. Brain Struct. Funct. 221(9), 4705–4721 (2016)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this paper
Cite this paper
Rheault, F., St-Onge, E., Sidhu, J., Chenot, Q., Petit, L., Descoteaux, M. (2018). Bundle-Specific Tractography. In: Kaden, E., Grussu, F., Ning, L., Tax, C., Veraart, J. (eds) Computational Diffusion MRI. Mathematics and Visualization. Springer, Cham. https://doi.org/10.1007/978-3-319-73839-0_10
Download citation
DOI: https://doi.org/10.1007/978-3-319-73839-0_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-73838-3
Online ISBN: 978-3-319-73839-0
eBook Packages: Mathematics and StatisticsMathematics and Statistics (R0)