Abstract
In vivo single voxel 1H-MR measurements were performed in a rat’s brain on a clinical whole-body 3 T MR scanner by using a dedicated small animal head RF-coil. Spectroscopic experiments were performed with and without water suppression as well as with different echo times (TE) by placing a 0.5 ml voxel in the rat cerebrum. Absolute concentrations of tNAA, tCr, tCho, mIns, Lac and Glu were estimated by applying the internal tissue water reference technique. In addition, T2 values for tNAA, tCr and tCho were determined by mono-exponential fitting of metabolite intensities sampled at the different echo times.
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© 2009 International Federation for Medical and Biological Engineering
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Gussew, A., Rzanny, R., Herrmann, K.H., Schmidt, S., Witte, O.W., Reichenbach, J.R. (2009). In vivo 1H-MRS of the rat brain with a clinical 3 T whole-body MR Scanner: Estimation of absolute metabolic concentrations and T2 values. In: Dössel, O., Schlegel, W.C. (eds) World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. IFMBE Proceedings, vol 25/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03879-2_140
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DOI: https://doi.org/10.1007/978-3-642-03879-2_140
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-03878-5
Online ISBN: 978-3-642-03879-2
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