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Dofetilide effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study

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VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016

Part of the book series: IFMBE Proceedings ((IFMBE,volume 60))

Abstract

Atrial fibrillation is the most common sustained cardiac arrhythmia. Dofetilide is an antiarrhythmic drug for the treatment of chronic AF that specifically blocks the rapid component of the delayed rectifier potassium current I Kr . Dofetilide prolongs the action potential duration and QT interval in a concentration-dependent fashion, therefore, the risk of QT prolongation is dose related. It is important to study the electrophysiological effects of dofetilide at different concentrations in human atrial cells. For this, we simulated the effects of dofetilide on human atrial cell and studied its effect on atrial action potential under normal conditions and during cAF. We developed a model of dofetilide effects on I Kr and I KACh . Our results show that dofetilide blocks both currents in a fraction greater as the concentration increases, which results in an action potential duration lengthening. To our knowledge, this is the first work that has developed mathematical models of dofetilide effects on I Kr and I KACh currents to study its effect on human atrial action potential.

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Author information

Authors and Affiliations

  1. MATBIOM, Universidad de Medellín, Medellín, Colombia

    C. Tobón

  2. Grupo de Dinámica Cardiovascular, Universidad Pontificia Bolivariana, Medellín, Colombia

    S. Pérez & J. P. Ugarte

  3. CI2B, Universitat Politècnica de València, Valencia, Spain

    J. Saiz

Authors
  1. C. Tobón
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  2. S. Pérez
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  3. J. P. Ugarte
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  4. J. Saiz
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Corresponding author

Correspondence to C. Tobón .

Editor information

Editors and Affiliations

  1. Asociación Colombiana de Bioingeniería y Electrónica Médica - ABIOIN, Bucamaranga, Colombia

    Isnardo Torres

  2. Universidad Pontificia Bolivariana - UPB, Centro de Bioingeniería, Medellín, Colombia

    John Bustamante

  3. Universidad Industrial de Santander, Escuela de Ing. Eléctrica, Electrónica, Bucaramanga, Colombia

    Daniel A. Sierra

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Tobón, C., Pérez, S., Ugarte, J.P., Saiz, J. (2017). Dofetilide effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study. In: Torres, I., Bustamante, J., Sierra, D. (eds) VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016. IFMBE Proceedings, vol 60. Springer, Singapore. https://doi.org/10.1007/978-981-10-4086-3_10

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  • DOI: https://doi.org/10.1007/978-981-10-4086-3_10

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4085-6

  • Online ISBN: 978-981-10-4086-3

  • eBook Packages: EngineeringEngineering (R0)

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