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Mapping of neurokinin b in the cat brainstem

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Abstract

We studied the distribution of neurokinin B-immunoreactive cell bodies and fibers in the cat brainstem using an indirect immunoperoxidase technique. The highest density of immunoreactive fibers was found in the motor trigeminal nucleus, the laminar and alaminar spinal trigeminal nuclei, the facial nucleus, the marginal nucleus of the brachium conjunctivum, the locus coeruleus, the cuneiform nucleus, the dorsal motor nucleus of the vagus, the postpyramidal nucleus of the raphe, the lateral tegmental field, the Kölliker-Fuse nucleus, the inferior central nucleus, the periaqueductal gray, the nucleus of the solitary tract, and in the inferior vestibular nucleus. Immunoreactive cell bodies containing neurokinin B were observed, for example, in the locus coeruleus, the dorsal motor nucleus of the vagus, the median division of the dorsal nucleus of the raphe, the lateral tegmental field, the pericentral nucleus of the inferior colliculus, the internal division of the lateral reticular nucleus, the inferior central nucleus, the periaqueductal gray, the postpyramidal nucleus of the raphe, and in the medial nucleus of the solitary tract. This widespread distribution of neurokinin B in the cat brainstem suggests that the neuropeptide could be involved in many different physiological functions. In comparison with previous studies carried out in the rat brainstem on the distribution of neurokinin B, our results point to a more widespread distribution of this neuropeptide in the cat brainstem.

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Abbreviations

5M:

Motor trigeminal nucleus

5MD:

Motor trigeminal nucleus, dorsal division

5ME:

Mesencephalic trigeminal nucleus

5MT:

Motor trigeminal tract

5MV:

Motor trigeminal nucleus, ventral division

5P:

Principal sensory trigeminal nucleus

5PD:

Principal sensory trigeminal nucleus, dorsal division

5PV:

Principal sensory trigeminal nucleus, ventral division

5SL:

Laminar spinal trigeminal nucleus

5SM:

Alaminar spinal trigeminal nucleus, magnocellular division

5SP:

Alaminar spinal trigeminal nucleus, parvocellular division

5ST:

Spinal trigeminal tract

6:

Abducens nucleus

7G:

Genu of the facial nerve

7L:

Facial nucleus, lateral division

7M:

Facial nucleus, medial division

7N:

Facial nerve

12:

Hypoglossal nucleus

12N:

Hypoglossal nerve

AMB:

Nucleus ambiguus

AP:

Area postrema

AQ:

Aqueduct

BC:

Brachium conjunctivum

BCM:

Marginal nucleus of the brachium conjunctivum

BP:

Brachium pontis

CAE:

Locus coeruleus

CD:

Dorsal cochlear nucleus

CE:

Central canal

CI:

Inferior central nucleus

CNF:

Cuneiform nucleus

CS:

Superior central nucleus

CUC:

Cuneate nucleus, caudal division

CUR:

Cuneate nucleus, rostral division

CX:

External cuneate nucleus

DMV:

Dorsal motor nucleus of the vagus

DRL:

Dorsal nucleus of the raphe, lateral division

DRM:

Dorsal nucleus of the raphe, median division

FTC:

Central tegmental field

FTG:

Gigantocellular tegmental field

FTL:

Lateral tegmental field

FTM:

Magnocellular tegmental field

FTP:

Paralemniscal tegmental field

GRC:

Gracile nucleus, caudal division

GRR:

Gracile nucleus, rostral division

ICC:

Central nucleus of the inferior colliculus

ICO:

Commissure of the inferior colliculi

ICP:

Pericentral nucleus of the inferior colliculus

ICX:

External nucleus of the inferior colliculus

IFT:

Infratrigeminal nucleus

INC:

Nucleus incertus

INT:

Nucleus intercalatus

IO:

Inferior olive

KF:

Kölliker-Fuse nucleus

LLD:

Dorsal nucleus of the lateral lemniscus

LLV:

Ventral nucleus of the lateral lemniscus

LRI:

Lateral reticular nucleus, internal division

LRX:

Lateral reticular nucleus, external division

MLB:

Medial longitudinal bundle

MLX:

Decussation of the medial lemniscus

P:

Pyramidal tract

PAG:

Periaqueductal gray

PGD:

Pontine gray, dorsolateral division

PGM:

Pontine gray, medial division

PGL:

Pontine gray, lateral division

PH:

Nucleus praepositus hypoglossi

PPR:

Postpyramidal nucleus of the raphe

PR:

Paramedian reticular nucleus

RB:

Restiform body

RFN:

Retrofacial nucleus

RR:

Retrorubral nucleus

S:

Solitary tract

SAG:

Nucleus sagulum

SC:

Superior colliculus

SGL:

Subependymal granular layer

SM:

Medial nucleus of the solitary tract

SOL:

Lateral nucleus of the superior olive

SOM:

Medial nucleus of the superior olive

T:

Nucleus of the trapezoid body

TAD:

Accessory dorsal tegmental nucleus

TDP:

Dorsal tegmental nucleus, pericentral division

TRC:

Tegmental reticular nucleus, central division

TRP:

Tegmental reticular nucleus, paracentral division

TV:

Ventral tegmental nucleus

VIN:

Inferior vestibular nucleus

VLD:

Lateral vestibular nucleus, dorsal division

VLV:

Lateral vestibular nucleus, ventral division

VMN:

Medial vestibular nucleus

VSL:

Superior vestibular nucleus, lateral division

VSM:

Superior vestibular nucleus, medial division

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Acknowledgements

The authors wish to thank N. Skinner for the revision of the English text. This work has been supported by the Ministerio de Ciencia y Tecnología (BFI2001–1906), Spain. L.A. Aguilar was supported by the Fundación Carolina (Spain).

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Authors and Affiliations

  1. Laboratory of Neuroanatomy of the Peptidergic Systems Facultad de Medicina, Instituto de Neurociencias de Castilla y León (INCYL), c/Alfonso X El Sabio s/n, 37007, Salamanca, Spain

    I. Cuadrado & R. Coveñas

  2. Faculty of Veterinary Medicine and Animal Sciences, Division of Neuroscience and Behavior, Laboratory of Pathology, Peruvian University Cayetano Heredia, Lima, 31, Peru

    L. A. Aguilar

  3. Department of Physiology, University of Málaga, School of Medicine, 29080, Málaga, Spain

    J. A. Aguirre, J. Rioja & J. A. Narvaez

Authors
  1. I. Cuadrado
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  2. R. Coveñas
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  3. L. A. Aguilar
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  4. J. A. Aguirre
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  5. J. Rioja
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  6. J. A. Narvaez
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Corresponding author

Correspondence to R. Coveñas.

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Cuadrado, I., Coveñas, R., Aguilar, L.A. et al. Mapping of neurokinin b in the cat brainstem. Anat Embryol 210, 133–143 (2005). https://doi.org/10.1007/s00429-005-0017-5

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