Abstract
The implantation of embryonic testis grafts into female chick embryos induces the regression of their Müllerian ducts (MDs) in a certain number of cases. The treatment of either the grafts or the grafted females with testosterone propionate (TP) results in a significant increase in the number of MD regressions observed. Our data are interpretable in terms of a direct activation by TP of the anti-Müllerian activity of the embryonic testis. We discuss a possible mechanism accounting for the synergistic action of testosterone and anti-Müllerian hormone.
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R. Stoll (1912–1994) dedicated his life to developmental endocrinology and actively contributed to the knowledge of sex differentiation until his last days
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Ichas, F., Faucounau, N., Stoll, R. et al. Action of testosterone on the anti-Müllerian activity of the chick embryonic testis assayed in vivo by organotypic grafting. Anat Embryol 190, 297–299 (1994). https://doi.org/10.1007/BF00234307
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DOI: https://doi.org/10.1007/BF00234307