Abstract
The experimentally induced rooting response can be elicited at birth in inbred strains of mice and disappears between 6 and 12 days of age. The age at disappearance of the rooting response (ADR) varies across strains. At 9 days of age, only 18% of C57BL/6By pups present the response, whereas 86% of BALB/cBy pups still exhibit it. Both the recombinant inbred strains method (using CXB stocks) and Mendelian crosses were used to analyze this difference. The results led to identical conclusions: early ADR is an incompletely dominant trait, correlated to one segragating unit, labeled Adre. Three independent techniques were used to map the new locus: the strain distribution pattern of the CXB recombinant strains, a comparison of the recombination proportion of Adre with previously mapped loci, and congenic strains. The findings are congruent and show that Adre is linked to brown (b), Mup-1, and the minor histocompatibility antigen locus H-21 on chromosome 4.
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This research was supported by the CNRS (UA 656, ATP to M. Carlier), MEN (Paris V, UER Biomédicale, ATP Biology 84 to P. L. Roubertoux), and Fondation pour la Recherche Médicale.
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Roubertoux, P.L., Baumann, L., Ragueneau, S. et al. Early development in mice. IV. Age at disappearance of the rooting response: Genetic analysis in newborn mice. Behav Genet 17, 453–464 (1987). https://doi.org/10.1007/BF01073112
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DOI: https://doi.org/10.1007/BF01073112