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Multiple controls exerted by 5-HT2C receptors upon basal ganglia function: from physiology to pathophysiology

  • Serotonin
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Abstract

Serotonin2C (5-HT2C) receptors are expressed in the basal ganglia, a group of subcortical structures involved in the control of motor behaviour, mood and cognition. These receptors are mediating the effects of 5-HT throughout different brain areas via projections originating from midbrain raphe nuclei. A growing interest has been focusing on the function of 5-HT2C receptors in the basal ganglia because they may be involved in various diseases of basal ganglia function notably those associated with chronic impairment of dopaminergic transmission. 5-HT2C receptors act on numerous types of neurons in the basal ganglia, including dopaminergic, GABAergic, glutamatergic or cholinergic cells. Perhaps inherent to their peculiar molecular properties, the modality of controls exerted by 5-HT2C receptors over these cell populations can be phasic, tonic (dependent on the 5-HT tone) or constitutive (a spontaneous activity without the presence of the ligand). These controls are functionally organized in the basal ganglia: they are mainly localized in the input structures and preferentially distributed in the limbic/associative territories of the basal ganglia. The nature of these controls is modified in neuropsychiatric conditions such as Parkinson’s disease, tardive dyskinesia or addiction. Most of the available data indicate that the function of 5-HT2C receptor is enhanced in cases of chronic alterations of dopamine neurotransmission. The review illustrates that 5-HT2C receptors play a role in maintaining continuous controls over the basal ganglia via multiple diverse actions. We will discuss their interest for treatments aimed at ameliorating current pharmacotherapies in schizophrenia, Parkinson’s disease or drugs abuse.

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Abbreviations

5-HT2C receptor:

Serotonin2C receptor

5-HT:

Serotonin

DRN:

Dorsal raphe nucleus

MRN:

Medial raphe nucleus

5,7-DHT:

5,7-Dihydroxytryptamine

DA:

Dopamine

6-OHDA:

6-Hydroxydopamine

MPTP:

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

CNS:

Central nervous system

HFS:

High-frequency stimulation

NAc:

Nucleus accumbens

STN:

Subthalamic nucleus

EPN:

Entopeduncular nucleus

GPi:

Internal globus pallidus

GPe:

External globus pallidus

SNc:

Substantia nigra pars compacta

SNr:

Substantia nigra pars reticulata

VTA:

Ventral tegmental area

OFC:

Orbitofrontal cortex

mPFC:

Medial prefrontal cortex

8-OH-DPAT:

8-Hydroxy-2-(di-n-propylamino)tetralin

m-CPP:

Metachlorophenylpiperazine

TFMPP:

Trifluoromethylphenylpiperazine

DOI:

1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane

DOB:

2,5-Dimethoxy-4-bromoamphetamine

MK-212:

2-Chloro-6-(1-piperazinyl)pyrazine

RU-29469:

5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole

Ro 60-0175:

S-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine

WAY-163909:

(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole

SB 228357:

1-5[-fluoro-3-(3-pyridyl)phenyl-carbamoyl]-5-methoxy-6-trifluoromethylindoline

SB 206553:

5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole

S32006:

N-Pyridin-3-yl-1,2-dihydro-3H-benzo[e]indole-3-carboxamide

SB 242084:

6-Chloro-5-methyl-1-[6-(2-methylpiridin-3-yloxy)pyridine-3-yl carbamoyl] indoline

SB 243213:

5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline

SDZ SER-082:

(+)-cis 4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine

RS-102221:

N-{5-[5-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)pentanoyl] -2,4-dimethoxyphenyl}-4-(trifluoromethyl)benzenesulfonamide

SB-215505:

(6-Chloro-5-methyl-1-(5-quinolylcarbamoyl) indoline

MDL-100907:

(R-(+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol)

SB 200646:

N-(1-methyl-5-indolyl)-N′-(3-pyridyl) urea

GAD:

Glutamic acid decarboxylase

TH:

Tyrosine hydroxylase

RT-PCR:

Reverse transcription polymerase chain reaction

Q-PCR:

Quantitative polymerase chain reaction

IP:

Inositol phosphate

PLC:

Phospholipase C

PLA2 :

Phospholipase A2

BOLD:

Blood oxygen dependent level

fMRI:

Functional magnetic resonance imaging

OCD:

Obsessive compulsive disorders

ICD:

Impulse control disorders

5-CSRTT:

5-Choice serial reaction time task

EPS:

Extrapyramidal side effects

References

  • Abdallah L, Bonasera SJ, Hopf FW, O’Dell L, Giorgetti M, Jongsma M, Carra S, Pierucci M, Di Giovanni G, Esposito E, Parsons LH, Bonci A, Tecott LH (2009) Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. J Neurosci 29(25):8156–8165. doi:10.1523/JNEUROSCI.3905-08.2009

    PubMed  CAS  Google Scholar 

  • Adachi K, Hasegawa M, Fujita S, Sato M, Miwa Y, Ikeda H, Koshikawa N, Cools AR (2002) Dopaminergic and cholinergic stimulation of the ventrolateral striatum elicit rat jaw movements that are funnelled via distinct efferents. Eur J Pharmacol 442(1–2):81–92

    PubMed  CAS  Google Scholar 

  • Agnoli L, Carli M (2011) Synergistic interaction of dopamine D(1) and glutamate N-methyl-D-aspartate receptors in the rat dorsal striatum controls attention. Neuroscience 185:39–49. doi:10.1016/j.neuroscience.2011.04.044

    PubMed  CAS  Google Scholar 

  • Agnoli L, Carli M (2012) Dorsal-striatal 5-HT(2)A and 5-HT(2)C receptors control impulsivity and perseverative responding in the 5-choice serial reaction time task. Psychopharmacology 219(2):633–645. doi:10.1007/s00213-011-2581-0

    PubMed  CAS  Google Scholar 

  • Albin RL, Mink JW (2006) Recent advances in Tourette syndrome research. Trends Neurosci 29(3):175–182. doi:10.1016/j.tins.2006.01.001

    PubMed  CAS  Google Scholar 

  • Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12(10):366–375

    PubMed  CAS  Google Scholar 

  • Alex KD, Pehek EA (2007) Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113(2):296–320. doi:10.1016/j.pharmthera.2006.08.004

    PubMed  CAS  Google Scholar 

  • Alex KD, Yavanian GJ, McFarlane HG, Pluto CP, Pehek EA (2005) Modulation of dopamine release by striatal 5-HT2C receptors. Synapse 55(4):242–251

    PubMed  CAS  Google Scholar 

  • Alexander GE, Crutcher MD (1990) Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 13(7):266–271

    PubMed  CAS  Google Scholar 

  • Azmitia EC, Segal M (1978) An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Comp Neurol 179(3):641–667

    PubMed  CAS  Google Scholar 

  • Backstrom JR, Price RD, Reasoner DT, Sanders-Bush E (2000) Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses. J Biol Chem 275(31):23620–23626. doi:10.1074/jbc.M000922200

    PubMed  CAS  Google Scholar 

  • Baker DA, Tran-Nguyen TL, Fuchs RA, Neisewander JL (2001) Influence of individual differences and chronic fluoxetine treatment on cocaine-seeking behavior in rats. Psychopharmacology 155(1):18–26

    PubMed  CAS  Google Scholar 

  • Barker EL, Westphal RS, Schmidt D, Sanders-Bush E (1994) Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands. J Biol Chem 269(16):11687–11690

    PubMed  CAS  Google Scholar 

  • Barwick VS, Jones DH, Richter JT, Hicks PB, Young KA (2000) Subthalamic nucleus microinjections of 5-HT2 receptor antagonists suppress stereotypy in rats. NeuroReport 11(2):267–270

    PubMed  CAS  Google Scholar 

  • Basura GJ, Walker PD (2001) Serotonin 2A receptor regulation of striatal neuropeptide gene expression is selective for tachykinin, but not enkephalin neurons following dopamine depletion. Brain Res Mol Brain Res 92(1–2):66–77

    PubMed  CAS  Google Scholar 

  • Belforte JE, Pazo JH (2004) Turning behaviour induced by stimulation of the 5-HT receptors in the subthalamic nucleus. Eur J Neurosci 19(2):346–355

    PubMed  CAS  Google Scholar 

  • Belin D, Everitt BJ (2008) Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron 57(3):432–441. doi:10.1016/j.neuron.2007.12.019

    PubMed  CAS  Google Scholar 

  • Bengtson CP, Lee DJ, Osborne PB (2004) Opposing electrophysiological actions of 5-HT on noncholinergic and cholinergic neurons in the rat ventral pallidum in vitro. J Neurophysiol 92(1):433–443. doi:10.1152/jn.00543.2003

    PubMed  CAS  Google Scholar 

  • Berg KA, Maayani S, Goldfarb J, Scaramellini C, Leff P, Clarke WP (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Mol Pharmacol 54(1):94–104

    PubMed  CAS  Google Scholar 

  • Berg KA, Cropper JD, Niswender CM, Sanders-Bush E, Emeson RB, Clarke WP (2001) RNA-editing of the 5-HT(2C) receptor alters agonist-receptor-effector coupling specificity. Br J Pharmacol 134(2):386–392. doi:10.1038/sj.bjp.0704255

    PubMed  CAS  Google Scholar 

  • Berg KA, Harvey JA, Spampinato U, Clarke WP (2005) Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors. Trends Pharmacol Sci 26(12):625–630. doi:10.1016/j.tips.2005.10.008

    PubMed  CAS  Google Scholar 

  • Berg KA, Navailles S, Sanchez TA, Silva YM, Wood MD, Spampinato U, Clarke WP (2006) Differential effects of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxyl]-5-pyridyl]carbamoyl]-6-trifluoro methylindone (SB 243213) on 5-hydroxytryptamine(2C) receptor-mediated responses. J Pharmacol Exp Ther 319(1):260–268

    PubMed  CAS  Google Scholar 

  • Berg KA, Dunlop J, Sanchez T, Silva M, Clarke WP (2008a) A conservative, single-amino acid substitution in the second cytoplasmic domain of the human Serotonin2C receptor alters both ligand-dependent and -independent receptor signaling. J Pharmacol Exp Ther 324(3):1084–1092. doi:10.1124/jpet.107.131524

    PubMed  CAS  Google Scholar 

  • Berg KA, Harvey JA, Spampinato U, Clarke WP (2008b) Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression. Prog Brain Res 172:287–305. doi:10.1016/S0079-6123(08)00914-X

    PubMed  CAS  Google Scholar 

  • Bersani G, Grispini A, Marini S, Pasini A, Valducci M, Ciani N (1990) 5-HT2 antagonist ritanserin in neuroleptic-induced parkinsonism: a double-blind comparison with orphenadrine and placebo. Clin Neuropharmacol 13(6):500–506

    PubMed  CAS  Google Scholar 

  • Beyeler A, Kadiri N, Navailles S, Boujema MB, Gonon F, Moine CL, Gross C, De Deurwaerdere P (2010) Stimulation of serotonin2C receptors elicits abnormal oral movements by acting on pathways other than the sensorimotor one in the rat basal ganglia. Neuroscience 169(1):158–170

    PubMed  CAS  Google Scholar 

  • Bianchi C, Siniscalchi A, Beani L (1989) Effect of 5-hydroxytryptamine on [3H]-acetylcholine release from guinea-pig striatal slices. Br J Pharmacol 97(1):213–221

    PubMed  CAS  Google Scholar 

  • Blackburn TP, Minabe Y, Middlemiss DN, Shirayama Y, Hashimoto K, Ashby CR Jr (2002) Effect of acute and chronic administration of the selective 5-HT2C receptor antagonist SB-243213 on midbrain dopamine neurons in the rat: an in vivo extracellular single cell study. Synapse 46(3):129–139

    PubMed  CAS  Google Scholar 

  • Blomeley C, Bracci E (2005) Excitatory effects of serotonin on rat striatal cholinergic interneurones. J Physiol 569(Pt 3):715–721. doi:10.1113/jphysiol.2005.098269

    PubMed  CAS  Google Scholar 

  • Blomeley CP, Bracci E (2009) Serotonin excites fast-spiking interneurons in the striatum. Eur J Neurosci 29(8):1604–1614. doi:10.1111/j.1460-9568.2009.06725.x

    PubMed  Google Scholar 

  • Bonifati V, Fabrizio E, Cipriani R, Vanacore N, Meco G (1994) Buspirone in levodopa-induced dyskinesias. Clin Neuropharmacol 17(1):73–82

    PubMed  CAS  Google Scholar 

  • Bonsi P, Cuomo D, Ding J, Sciamanna G, Ulrich S, Tscherter A, Bernardi G, Surmeier DJ, Pisani A (2007) Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors. Neuropsychopharmacology 32(8):1840–1854. doi:10.1038/sj.npp.1301294

    PubMed  CAS  Google Scholar 

  • Boulet S, Mounayar S, Poupard A, Bertrand A, Jan C, Pessiglione M, Hirsch EC, Feuerstein C, Francois C, Feger J, Savasta M, Tremblay L (2008) Behavioral recovery in MPTP-treated monkeys: neurochemical mechanisms studied by intrastriatal microdialysis. J Neurosci 28(38):9575–9584. doi:10.1523/JNEUROSCI.3465-08.2008

    PubMed  CAS  Google Scholar 

  • Boulougouris V, Robbins TW (2010) Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific. J Neurosci 30(3):930–938

    PubMed  CAS  Google Scholar 

  • Boulougouris V, Glennon JC, Robbins TW (2008) Dissociable effects of selective 5-HT2A and 5-HT2C receptor antagonists on serial spatial reversal learning in rats. Neuropsychopharmacology 33(8):2007–2019

    PubMed  CAS  Google Scholar 

  • Braak H, Rub U, Gai WP, Del Tredici K (2003) Idiopathic Parkinson’s disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 110(5):517–536. doi:10.1007/s00702-002-0808-2

    PubMed  CAS  Google Scholar 

  • Bruggeman R, Heeringa M, Westerink BH, Timmerman W (2000) Combined 5-HT2/D2 receptor blockade inhibits the firing rate of SNR neurons in the rat brain. Prog Neuropsychopharmacol Biol Psychiatry 24(4):579–593

    PubMed  CAS  Google Scholar 

  • Brus R, Plech A, Kostrzewa RM (1995) Enhanced quinpirole response in rats lesioned neonatally with 5,7-dihydroxytryptamine. Pharmacol Biochem Behav 50(4):649–653

    PubMed  CAS  Google Scholar 

  • Bubar MJ, Cunningham KA (2007) Distribution of serotonin 5-HT2C receptors in the ventral tegmental area. Neuroscience 146(1):286–297. doi:10.1016/j.neuroscience.2006.12.071

    PubMed  CAS  Google Scholar 

  • Bubar MJ, Cunningham KA (2008) Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse. Prog Brain Res 172:319–346. doi:10.1016/S0079-6123(08)00916-3

    PubMed  CAS  Google Scholar 

  • Bubar MJ, Stutz SJ, Cunningham KA (2011) 5-HT(2C) receptors localize to dopamine and GABA neurons in the rat mesoaccumbens pathway. PLoS ONE 6(6):e20508. doi:10.1371/journal.pone.0020508

    PubMed  CAS  Google Scholar 

  • Burbassi S, Cervo L (2008) Stimulation of serotonin2C receptors influences cocaine-seeking behavior in response to drug-associated stimuli in rats. Psychopharmacology 196(1):15–27. doi:10.1007/s00213-007-0916-7

    PubMed  CAS  Google Scholar 

  • Burmeister JJ, Lungren EM, Neisewander JL (2003) Effects of fluoxetine and d-fenfluramine on cocaine-seeking behavior in rats. Psychopharmacology 168(1–2):146–154. doi:10.1007/s00213-002-1307-8

    PubMed  CAS  Google Scholar 

  • Burmeister JJ, Lungren EM, Kirschner KF, Neisewander JL (2004) Differential roles of 5-HT receptor subtypes in cue and cocaine reinstatement of cocaine-seeking behavior in rats. Neuropsychopharmacology 29(4):660–668. doi:10.1038/sj.npp.1300346

    PubMed  CAS  Google Scholar 

  • Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB (1997) Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 387(6630):303–308

    PubMed  CAS  Google Scholar 

  • Burstein ES, Spalding TA, Brauner-Osborne H, Brann MR (1995) Constitutive activation of muscarinic receptors by the G-protein Gq. FEBS Lett 363(3):261–263

    PubMed  CAS  Google Scholar 

  • Cains S, Blomeley CP, Bracci E (2012) Serotonin inhibits low-threshold spike interneurons in the striatum. J Physiol 590(Pt 10):2241–2252. doi:10.1113/jphysiol.2011.219469

    PubMed  CAS  Google Scholar 

  • Calcagno E, Carli M, Baviera M, Invernizzi RW (2009) Endogenous serotonin and serotonin2C receptors are involved in the ability of M100907 to suppress cortical glutamate release induced by NMDA receptor blockade. J Neurochem 108(2):521–532. doi:10.1111/j.1471-4159.2008.05789.x

    PubMed  CAS  Google Scholar 

  • Canton H, Verriele L, Colpaert FC (1990) Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites. Eur J Pharmacol 191(1):93–96

    PubMed  CAS  Google Scholar 

  • Carli M, Samanin R (2000) The 5-HT(1A) receptor agonist 8-OH-DPAT reduces rats’ accuracy of attentional performance and enhances impulsive responding in a five-choice serial reaction time task: role of presynaptic 5-HT(1A) receptors. Psychopharmacology 149(3):259–268

    PubMed  CAS  Google Scholar 

  • Carlson BB, Wisniecki A, Salamone JD (2003) Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor. Psychopharmacology 165(3):229–237

    PubMed  CAS  Google Scholar 

  • Carroll ME, Lac ST, Asencio M, Kragh R (1990) Fluoxetine reduces intravenous cocaine self-administration in rats. Pharmacol Biochem Behav 35(1):237–244

    PubMed  CAS  Google Scholar 

  • Chen L, Yung KK, Chan YS, Yung WH (2008) 5-HT excites globus pallidus neurons by multiple receptor mechanisms. Neuroscience 151(2):439–451. doi:10.1016/j.neuroscience.2007.11.003

    PubMed  CAS  Google Scholar 

  • Chesselet MF, Delfs JM (1996) Basal ganglia and movement disorders: an update. Trends Neurosci 19(10):417–422

    PubMed  CAS  Google Scholar 

  • Chou-Green JM, Holscher TD, Dallman MF, Akana SF (2003) Compulsive behavior in the 5-HT2C receptor knockout mouse. Physiol Behav 78(4–5):641–649

    PubMed  CAS  Google Scholar 

  • Clarke HF, Dalley JW, Crofts HS, Robbins TW, Roberts AC (2004) Cognitive inflexibility after prefrontal serotonin depletion. Science 304(5672):878–880

    PubMed  CAS  Google Scholar 

  • Clarke G, Debar L, Lynch F, Powell J, Gale J, O’Connor E, Ludman E, Bush T, Lin EH, Von Korff M, Hertert S (2005) A randomized effectiveness trial of brief cognitive-behavioral therapy for depressed adolescents receiving antidepressant medication. J Am Acad Child Adolesc Psychiatry 44(9):888–898

    PubMed  Google Scholar 

  • Clemett DA, Punhani T, Duxon MS, Blackburn TP, Fone KC (2000) Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS. Neuropharmacology 39(1):123–132

    PubMed  CAS  Google Scholar 

  • Conn PJ, Sanders-Bush E, Hoffman BJ, Hartig PR (1986) A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover. Proc Natl Acad Sci USA 83(11):4086–4088

    PubMed  CAS  Google Scholar 

  • Cook DF, Wirtshafter D (1995) Serotonin agonist-induced c-fos expression in the rat striatum. Soc Neurosci 21, Abstract 1424

  • Corvaja N, Doucet G, Bolam JP (1993) Ultrastructure and synaptic targets of the raphe-nigral projection in the rat. Neuroscience 55(2):417–427

    PubMed  CAS  Google Scholar 

  • Creed M, Hamani C, Nobrega JN (2011) Deep brain stimulation of the subthalamic or entopeduncular nucleus attenuates vacuous chewing movements in a rodent model of tardive dyskinesia. Eur Neuropsychopharmacol 21(5):393–400. doi:10.1016/j.euroneuro.2010.06.012

    PubMed  CAS  Google Scholar 

  • Creed MC, Hamani C, Bridgman A, Fletcher PJ, Nobrega JN (2012) Contribution of decreased serotonin release to the antidyskinetic effects of deep brain stimulation in a rodent model of tardive dyskinesia: comparison of the subthalamic and entopeduncular nuclei. J Neurosci 32(28):9574–9581. doi:10.1523/JNEUROSCI.1196-12.2012

    PubMed  CAS  Google Scholar 

  • Creed-Carson M, Oraha A, Nobrega JN (2011) Effects of 5-HT(2A) and 5-HT(2C) receptor antagonists on acute and chronic dyskinetic effects induced by haloperidol in rats. Behav Brain Res 219(2):273–279. doi:10.1016/j.bbr.2011.01.025

    PubMed  CAS  Google Scholar 

  • Cudennec A, Duverger D, Serrano A, Scatton B, MacKenzie ET (1988) Influence of ascending serotonergic pathways on glucose use in the conscious rat brain. II. Effects of electrical stimulation of the rostral raphe nuclei. Brain Res 444(2):227–246

    PubMed  CAS  Google Scholar 

  • Cunningham KA, Fox RG, Anastasio NC, Bubar MJ, Stutz SJ, Moeller FG, Gilbertson SR, Rosenzweig-Lipson S (2011) Selective serotonin 5-HT(2C) receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- versus sucrose-associated cues. Neuropharmacology 61(3):513–523. doi:10.1016/j.neuropharm.2011.04.034

    PubMed  CAS  Google Scholar 

  • Curzon G, Kennett GA (1990) m-CPP: a tool for studying behavioural responses associated with 5-HT1c receptors. Trends Pharmacol Sci 11(5):181–182

    PubMed  CAS  Google Scholar 

  • Dalton GL, Lee MD, Kennett GA, Dourish CT, Clifton PG (2004) mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes. Neuropharmacology 46(5):663–671

    PubMed  CAS  Google Scholar 

  • Davies J, Tongroach P (1978) Neuropharmacological studies on the nigro-striatal and raphe-striatal system in the rat. Eur J Pharmacol 51(2):91–100

    PubMed  CAS  Google Scholar 

  • De Deurwaerdere P, Chesselet MF (2000) Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats. J Neurosci 20(13):5170–5178

    PubMed  Google Scholar 

  • De Deurwaerdere P, Spampinato U (1999) Role of serotonin(2A) and serotonin(2B/2C) receptor subtypes in the control of accumbal and striatal dopamine release elicited in vivo by dorsal raphe nucleus electrical stimulation. J Neurochem 73(3):1033–1042

    PubMed  Google Scholar 

  • De Deurwaerdere P, Navailles S, Berg KA, Clarke WP, Spampinato U (2004) Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. J Neurosci 24(13):3235–3241

    PubMed  Google Scholar 

  • De Deurwaerdere P, Le Moine C, Chesselet MF (2010) Selective blockade of serotonin 2C receptor enhances Fos expression specifically in the striatum and the subthalamic nucleus within the basal ganglia. Neurosci Lett 469(2):251–255

    PubMed  Google Scholar 

  • de Leeuw AS, Westenberg HG (2008) Hypersensitivity of 5-HT2 receptors in OCD patients. An increased prolactin response after a challenge with meta-chlorophenylpiperazine and pre-treatment with ritanserin and placebo. J Psychiatr Res 42(11):894–901. doi:10.1016/j.jpsychires.2007.09.001

    PubMed  Google Scholar 

  • Dekeyne A, Mannoury la Cour C, Gobert A, Brocco M, Lejeune F, Serres F, Sharp T, Daszuta A, Soumier A, Papp M, Rivet JM, Flik G, Cremers TI, Muller O, Lavielle G, Millan MJ (2008) S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models. Psychopharmacology 199(4):549–568

    PubMed  CAS  Google Scholar 

  • DeLong MR (1990) Primate models of movement disorders of basal ganglia origin. Trends Neurosci 13(7):281–285

    PubMed  CAS  Google Scholar 

  • Deniau JM, Menetrey A, Charpier S (1996) The lamellar organization of the rat substantia nigra pars reticulata: segregated patterns of striatal afferents and relationship to the topography of corticostriatal projections. Neuroscience 73(3):761–781

    PubMed  CAS  Google Scholar 

  • Deutch AY, Moghaddam B, Innis RB, Krystal JH, Aghajanian GK, Bunney BS, Charney DS (1991) Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia. Schizophr Res 4(2):121–156

    PubMed  CAS  Google Scholar 

  • Di Giovanni G, De Deurwaerdere P, Di Mascio M, Di Matteo V, Esposito E, Spampinato U (1999) Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study. Neuroscience 91(2):587–597

    PubMed  Google Scholar 

  • Di Giovanni G, Di Matteo V, La Grutta V, Esposito E (2001) m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors. Neuroscience 103(1):111–116

    PubMed  Google Scholar 

  • Di Giovanni G, Di Matteo V, Pierucci M, Benigno A, Esposito E (2006) Serotonin involvement in the basal ganglia pathophysiology: could the 5-HT2C receptor be a new target for therapeutic strategies? Curr Med Chem 13(25):3069–3081

    PubMed  Google Scholar 

  • Di Matteo V, Di Giovanni G, Di Mascio M, Esposito E (1999) SB 242084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system. Neuropharmacology 38(8):1195–1205

    PubMed  Google Scholar 

  • Di Matteo V, Di Giovanni G, Di Mascio M, Esposito E (2000) Biochemical and electrophysiological evidence that RO 60–0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors. Brain Res 865(1):85–90

    PubMed  Google Scholar 

  • Di Matteo V, De Blasi A, Di Giulio C, Esposito E (2001) Role of 5-HT(2C) receptors in the control of central dopamine function. Trends Pharmacol Sci 22(5):229–232

    PubMed  Google Scholar 

  • Di Matteo V, Cacchio M, Di Giulio C, Esposito E (2002) Role of serotonin(2C) receptors in the control of brain dopaminergic function. Pharmacol Biochem Behav 71(4):727–734

    PubMed  Google Scholar 

  • Di Matteo V, Pierucci M, Esposito E (2004) Selective stimulation of serotonin2c receptors blocks the enhancement of striatal and accumbal dopamine release induced by nicotine administration. J Neurochem 89(2):418–429. doi:10.1111/j.1471-4159.2004.02337.x

    PubMed  Google Scholar 

  • Di Matteo V, Pierucci M, Esposito E, Crescimanno G, Benigno A, Di Giovanni G (2008) Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson’s disease and other motor disorders. Prog Brain Res 172:423–463

    PubMed  Google Scholar 

  • Dragunow M, Butterworth N, Waldvogel H, Faull RL, Nicholson LF (1995) Prolonged expression of Fos-related antigens, Jun B and TrkB in dopamine-denervated striatal neurons. Brain Res Mol Brain Res 30(2):393–396

    PubMed  CAS  Google Scholar 

  • Dray A (1981) Serotonin in the basal ganglia: functions and interactions with other neuronal pathways. J de physiologie 77(2–3):393–403

    CAS  Google Scholar 

  • Dunlop J, Sabb AL, Mazandarani H, Zhang J, Kalgaonker S, Shukhina E, Sukoff S, Vogel RL, Stack G, Schechter L, Harrison BL, Rosenzweig-Lipson S (2005) WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indol e], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity. J Pharmacol Exp Ther 313(2):862–869. doi:10.1124/jpet.104.075382

    PubMed  CAS  Google Scholar 

  • Eberle-Wang K, Lucki I, Chesselet MF (1996) A role for the subthalamic nucleus in 5-HT2C-induced oral dyskinesia. Neuroscience 72(1):117–128

    PubMed  CAS  Google Scholar 

  • Eberle-Wang K, Mikeladze Z, Uryu K, Chesselet MF (1997) Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats. J Comp Neurol 384(2):233–247

    PubMed  CAS  Google Scholar 

  • Egan MF, Hurd Y, Ferguson J, Bachus SE, Hamid EH, Hyde TM (1996) Pharmacological and neurochemical differences between acute and tardive vacuous chewing movements induced by haloperidol. Psychopharmacology 127(4):337–345

    PubMed  CAS  Google Scholar 

  • el Mansari M, Blier P (1997) In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex. Neuropharmacology 36(4–5):577–588

    PubMed  CAS  Google Scholar 

  • el Mansari M, Radja F, Ferron A, Reader TA, Molina-Holgado E, Descarries L (1994) Hypersensitivity to serotonin and its agonists in serotonin-hyperinnervated neostriatum after neonatal dopamine denervation. Eur J Pharmacol 261(1–2):171–178

    PubMed  Google Scholar 

  • Euvrard C, Javoy F, Herbet A, Glowinski J (1977) Effect of quipazine, a serotonin-like drug, on striatal cholinergic interneurones. Eur J Pharmacol 41(3):281–289

    PubMed  CAS  Google Scholar 

  • Filip M, Cunningham KA (2002) Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine. Pharmacol Biochem Behav 71(4):745–756

    PubMed  CAS  Google Scholar 

  • Filip M, Cunningham KA (2003) Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin(2C) (5-HT(2C)) receptors in rat prefrontal cortex. J Pharmacol Exp Ther 306(2):734–743. doi:10.1124/jpet.102.045716

    PubMed  CAS  Google Scholar 

  • Filip M, Bubar MJ, Cunningham KA (2004) Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. J Pharmacol Exp Ther 310(3):1246–1254. doi:10.1124/jpet.104.068841

    PubMed  CAS  Google Scholar 

  • Fineberg NA, Potenza MN, Chamberlain SR, Berlin HA, Menzies L, Bechara A, Sahakian BJ, Robbins TW, Bullmore ET, Hollander E (2010) Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review. Neuropsychopharmacology 35(3):591–604

    PubMed  Google Scholar 

  • Fletcher PJ, Korth KM, Chambers JW (1999) Depletion of brain serotonin following intra-raphe injections of 5,7-dihydroxytryptamine does not alter d-amphetamine self-administration across different schedule and access conditions. Psychopharmacology 146(2):185–193

    PubMed  CAS  Google Scholar 

  • Fletcher PJ, Grottick AJ, Higgins GA (2002) Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding. Neuropsychopharmacology 27(4):576–586

    PubMed  CAS  Google Scholar 

  • Fletcher PJ, Chintoh AF, Sinyard J, Higgins GA (2004) Injection of the 5-HT2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration. Neuropsychopharmacology 29(2):308–318. doi:10.1038/sj.npp.1300319

    PubMed  CAS  Google Scholar 

  • Fletcher PJ, Tampakeras M, Sinyard J, Higgins GA (2007) Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test. Psychopharmacology 195(2):223–234. doi:10.1007/s00213-007-0891-z

    PubMed  CAS  Google Scholar 

  • Fletcher PJ, Rizos Z, Sinyard J, Tampakeras M, Higgins GA (2008) The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology 33(6):1402–1412. doi:10.1038/sj.npp.1301509

    PubMed  CAS  Google Scholar 

  • Fletcher PJ, Rizos Z, Noble K, Higgins GA (2011) Impulsive action induced by amphetamine, cocaine and MK801 is reduced by 5-HT(2C) receptor stimulation and 5-HT(2A) receptor blockade. Neuropharmacology 61(3):468–477. doi:10.1016/j.neuropharm.2011.02.025

    PubMed  CAS  Google Scholar 

  • Flores G, Rosales MG, Hernandez S, Sierra A, Aceves J (1995) 5-Hydroxytryptamine increases spontaneous activity of subthalamic neurons in the rat. Neurosci Lett 192(1):17–20

    PubMed  CAS  Google Scholar 

  • Fox S, Brotchie J (1996) Normethylclozapine potentiates the action of quinpirolee in the 6-hydroxydopamine lesioned rat. Eur J Pharmacol 301(1–3):27–30

    PubMed  CAS  Google Scholar 

  • Fox SH, Brotchie JM (2000a) 5-HT2C receptor binding is increased in the substantia nigra pars reticulata in Parkinson’s disease. Mov Disord 15(6):1064–1069

    PubMed  CAS  Google Scholar 

  • Fox SH, Brotchie JM (2000b) 5-HT(2C) receptor antagonists enhance the behavioural response to dopamine D(1) receptor agonists in the 6-hydroxydopamine-lesioned rat. Eur J Pharmacol 398(1):59–64

    PubMed  CAS  Google Scholar 

  • Fox SH, Moser B, Brotchie JM (1998) Behavioral effects of 5-HT2C receptor antagonism in the substantia nigra zona reticulata of the 6-hydroxydopamine-lesioned rat model of Parkinson’s disease. Exp Neurol 151(1):35–49

    PubMed  CAS  Google Scholar 

  • Fox SH, Chuang R, Brotchie JM (2008) Parkinson’s disease–opportunities for novel therapeutics to reduce the problems of levodopa therapy. Prog Brain Res 172:479–494. doi:10.1016/S0079-6123(08)00923-0

    PubMed  CAS  Google Scholar 

  • Gardell LR, Vanover KE, Pounds L, Johnson RW, Barido R, Anderson GT, Veinbergs I, Dyssegaard A, Brunmark P, Tabatabaei A, Davis RE, Brann MR, Hacksell U, Bonhaus DW (2007) ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental models. J Pharmacol Exp Ther 322(2):862–870. doi:10.1124/jpet.107.121715

    PubMed  CAS  Google Scholar 

  • Gardier AM, Moratalla R, Cuellar B, Sacerdote M, Guibert B, Lebrec H, Graybiel AM (2000) Interaction between the serotoninergic and dopaminergic systems in d-fenfluramine-induced activation of c-fos and jun B genes in rat striatal neurons. J Neurochem 74(4):1363–1373

    PubMed  CAS  Google Scholar 

  • Gerfen CR (1984) The neostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output systems. Nature 311(5985):461–464

    PubMed  CAS  Google Scholar 

  • Gerfen CR (1985) The neostriatal mosaic. I. Compartmental organization of projections from the striatum to the substantia nigra in the rat. J Comp Neurol 236(4):454–476. doi:10.1002/cne.902360404

    PubMed  CAS  Google Scholar 

  • Gerfen CR, Engber TM, Mahan LC, Susel Z, Chase TN, Monsma FJ Jr, Sibley DR (1990) D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 250(4986):1429–1432

    PubMed  CAS  Google Scholar 

  • Gillet G, Ammor S, Fillion G (1985) Serotonin inhibits acetylcholine release from rat striatum slices: evidence for a presynaptic receptor-mediated effect. J Neurochem 45(6):1687–1691

    PubMed  CAS  Google Scholar 

  • Gobert A, Rivet JM, Lejeune F, Newman-Tancredi A, Adhumeau-Auclair A, Nicolas JP, Cistarelli L, Melon C, Millan MJ (2000) Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat. Synapse 36(3):205–221

    PubMed  CAS  Google Scholar 

  • Goddard AW, Shekhar A, Whiteman AF, McDougle CJ (2008) Serotoninergic mechanisms in the treatment of obsessive-compulsive disorder. Drug Discovery Today 13(7–8):325–332. doi:10.1016/j.drudis.2007.12.009

    PubMed  CAS  Google Scholar 

  • Gong L, Kostrzewa RM (1992) Supersensitized oral responses to a serotonin agonist in neonatal 6-OHDA-treated rats. Pharmacol Biochem Behav 41(3):621–623

    PubMed  CAS  Google Scholar 

  • Gong L, Kostrzewa RM, Fuller RW, Perry KW (1992) Supersensitization of the oral response to SKF 38393 in neonatal 6-OHDA-lesioned rats is mediated through a serotonin system. J Pharmacol Exp Ther 261(3):1000–1007

    PubMed  CAS  Google Scholar 

  • Gong L, Kostrzewa RM, Perry KW, Fuller RW (1993) Dose-related effects of a neonatal 6-OHDA lesion on SKF 38393- and m-chlorophenylpiperazine-induced oral activity responses of rats. Brain Res Dev Brain Res 76(2):233–238

    PubMed  CAS  Google Scholar 

  • Gong L, Kostrzewa RM, Li C (1994) Neonatal 6-hydroxydopamine and adult SKF 38393 treatments alter dopamine D1 receptor mRNA levels: absence of other neurochemical associations with the enhanced behavioral responses of lesioned rats. J Neurochem 63(4):1282–1290

    PubMed  CAS  Google Scholar 

  • Gongora-Alfaro JL, Hernandez-Lopez S, Flores-Hernandez J, Galarraga E (1997) Firing frequency modulation of substantia nigra reticulata neurons by 5-hydroxytryptamine. Neurosci Res 29(3):225–231

    PubMed  CAS  Google Scholar 

  • Gray JA, Compton-Toth BA, Roth BL (2003) Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization. Biochemistry 42(36):10853–10862. doi:10.1021/bi035061z

    PubMed  CAS  Google Scholar 

  • Graybiel AM (1991) Basal ganglia–input, neural activity, and relation to the cortex. Curr Opin Neurobiol 1(4):644–651

    PubMed  CAS  Google Scholar 

  • Graybiel AM (2005) The basal ganglia: learning new tricks and loving it. Curr Opin Neurobiol 15(6):638–644. doi:10.1016/j.conb.2005.10.006

    PubMed  CAS  Google Scholar 

  • Grottick AJ, Fletcher PJ, Higgins GA (2000) Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior. J Pharmacol Exp Ther 295(3):1183–1191

    PubMed  CAS  Google Scholar 

  • Grottick AJ, Corrigall WA, Higgins GA (2001) Activation of 5-HT(2C) receptors reduces the locomotor and rewarding effects of nicotine. Psychopharmacology 157(3):292–298. doi:10.1007/s002130100801

    PubMed  CAS  Google Scholar 

  • Guigoni C, Li Q, Aubert I, Dovero S, Bioulac BH, Bloch B, Crossman AR, Gross CE, Bezard E (2005) Involvement of sensorimotor, limbic, and associative basal ganglia domains in L-3,4-dihydroxyphenylalanine-induced dyskinesia. J Neurosci 25(8):2102–2107. doi:10.1523/JNEUROSCI.5059-04.2005

    PubMed  CAS  Google Scholar 

  • Gunes A, Scordo MG, Jaanson P, Dahl ML (2007) Serotonin and dopamine receptor gene polymorphisms and the risk of extrapyramidal side effects in perphenazine-treated schizophrenic patients. Psychopharmacology 190(4):479–484. doi:10.1007/s00213-006-0622-x

    PubMed  CAS  Google Scholar 

  • Gunes A, Dahl ML, Spina E, Scordo MG (2008) Further evidence for the association between 5-HT2C receptor gene polymorphisms and extrapyramidal side effects in male schizophrenic patients. Eur J Clin Pharmacol 64(5):477–482. doi:10.1007/s00228-007-0450-x

    PubMed  CAS  Google Scholar 

  • Gurevich I, Englander MT, Adlersberg M, Siegal NB, Schmauss C (2002) Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission. J Neurosci 22(24):10529–10532

    PubMed  CAS  Google Scholar 

  • Hackler EA, Turner GH, Gresch PJ, Sengupta S, Deutch AY, Avison MJ, Gore JC, Sanders-Bush E (2007) 5-Hydroxytryptamine2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation. J Pharm Exp Ther 320:1023–1029

    CAS  Google Scholar 

  • Hale MW, Lowry CA (2011) Functional topography of midbrain and pontine serotonergic systems: implications for synaptic regulation of serotonergic circuits. Psychopharmacology 213(2–3):243–264. doi:10.1007/s00213-010-2089-z

    PubMed  CAS  Google Scholar 

  • Haleem DJ, Samad N, Haleem MA (2007a) Reversal of haloperidol-induced extrapyramidal symptoms by buspirone: a time-related study. Behav Pharmacol 18(2):147–153. doi:10.1097/FBP.0b013e3280dec67f

    PubMed  CAS  Google Scholar 

  • Haleem DJ, Samad N, Haleem MA (2007b) Reversal of haloperidol-induced tardive vacuous chewing movements and supersensitive somatodendritic serotonergic response by buspirone in rats. Pharmacol Biochem Behav 87(1):115–121. doi:10.1016/j.pbb.2007.04.007

    PubMed  CAS  Google Scholar 

  • Hartig PR, Hoffman BJ, Kaufman MJ, Hirata F (1990) The 5-HT1C receptor. Ann NY Acad Sci 600:149–166 (discussion 166–147)

    PubMed  CAS  Google Scholar 

  • Hashimoto K, Kita H (2008) Serotonin activates presynaptic and postsynaptic receptors in rat globus pallidus. J Neurophysiol 99(4):1723–1732. doi:10.1152/jn.01143.2007

    PubMed  CAS  Google Scholar 

  • Herrick-Davis K, Grinde E, Niswender CM (1999) Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction. J Neurochem 73(4):1711–1717

    PubMed  CAS  Google Scholar 

  • Herrick-Davis K, Grinde E, Teitler M (2000) Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors. J Pharmacol Exp Ther 295(1):226–232

    PubMed  CAS  Google Scholar 

  • Hicks PB (1990) The effect of serotonergic agents on haloperidol-induced catalepsy. Life Sci 47(18):1609–1615

    PubMed  CAS  Google Scholar 

  • Higgins GA, Fletcher PJ (2003) Serotonin and drug reward: focus on 5-HT2C receptors. Eur J Pharmacol 480(1–3):151–162

    PubMed  CAS  Google Scholar 

  • Higgins GA, Enderlin M, Haman M, Fletcher PJ (2003) The 5-HT2A receptor antagonist M100,907 attenuates motor and ‘impulsive-type’ behaviours produced by NMDA receptor antagonism. Psychopharmacology 170(3):309–319. doi:10.1007/s00213-003-1549-0

    PubMed  CAS  Google Scholar 

  • Hoffman BJ, Mezey E (1989) Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain. FEBS Lett 247(2):453–462

    PubMed  CAS  Google Scholar 

  • Hollander E, Mullen L, DeCaria CM, Skodol A, Schneier FR, Liebowitz MR, Klein DF (1991) Obsessive compulsive disorder, depression, and fluoxetine. J Clin Psychiatr 52(10):418–422

    CAS  Google Scholar 

  • Homberg JR (2012) Serotonin and decision making processes. Neurosci Biobehav Rev 36(1):218–236. doi:10.1016/j.neubiorev.2011.06.001

    PubMed  CAS  Google Scholar 

  • Howell LL, Byrd LD (1995) Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey. J Pharmacol Exp Ther 275(3):1551–1559

    PubMed  CAS  Google Scholar 

  • Hoyer D, Pazos A, Probst A, Palacios JM (1986) Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HT1C and 5-HT2 recognition sites. Brain Res 376(1):97–107

    PubMed  CAS  Google Scholar 

  • Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP (1994) International union of pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev 46(2):157–203

    PubMed  CAS  Google Scholar 

  • Hutson PH, Barton CL, Jay M, Blurton P, Burkamp F, Clarkson R, Bristow LJ (2000) Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT(2C/2B) receptor antagonists: neurochemical and behavioural studies. Neuropharmacology 39(12):2318–2328

    PubMed  CAS  Google Scholar 

  • Ikeguchi K, Kuroda A (1995) Mianserin treatment of patients with psychosis induced by antiparkinsonian drugs. Eur Arch Psychiatry Clin Neurosci 244(6):320–324

    PubMed  CAS  Google Scholar 

  • Ikram H, Samad N, Haleem DJ (2007) Neurochemical and behavioral effects of m-CPP in a rat model of tardive dyskinesia. Pak J Pharm Sci 20(3):188–195

    PubMed  CAS  Google Scholar 

  • Invernizzi RW, Cervo L, Samanin R (1988) 8-Hydroxy-2-(di-n-propylamino) tetralin, a selective serotonin1A receptor agonist, blocks haloperidol-induced catalepsy by an action on raphe nuclei medianus and dorsalis. Neuropharmacology 27(5):515–518

    PubMed  CAS  Google Scholar 

  • Invernizzi RW, Pierucci M, Calcagno E, Di Giovanni G, Di Matteo V, Benigno A, Esposito E (2007) Selective activation of 5-HT(2C) receptors stimulates GABA-ergic function in the rat substantia nigra pars reticulata: a combined in vivo electrophysiological and neurochemical study. Neuroscience 144(4):1523–1535

    PubMed  CAS  Google Scholar 

  • James TA, Starr MS (1980) Rotational behaviour elicited by 5-HT in the rat: evidence for an inhibitory role of 5-HT in the substantia nigra and corpus striatum. J Pharm Pharmacol 32(3):196–200

    PubMed  CAS  Google Scholar 

  • Janno S, Holi M, Tuisku K, Wahlbeck K (2004) Prevalence of neuroleptic-induced movement disorders in chronic schizophrenia inpatients. Am J Psychiatr 161(1):160–163

    PubMed  Google Scholar 

  • Janssen MLF, Zwartjes DGM, Temel Y, van Kranen-Mastenbroek V, Duits A, Bour LJ, Veltink PH, Heida T, Visser-Vandewalle V (2012) Subthalamic neuronal responses to cortical stimulation. Mov Disord 27:435–438. doi:10.1002/mds.24053

    PubMed  Google Scholar 

  • Javed A, Van de Kar LD, Gray TS (1998) The 5-HT1A and 5-HT2A/2C receptor antagonists WAY-100635 and ritanserin do not attenuate D-fenfluramine-induced fos expression in the brain. Brain Res 791(1–2):67–74

    PubMed  CAS  Google Scholar 

  • Julius D, MacDermott AB, Jessel TM, Huang K, Molineaux S, Schieren I, Axel R (1988) Functional expression of the 5-HT1c receptor in neuronal and nonneuronal cells. Cold Spring Harb Symp Quant Biol 53(Pt 1):385–393

    PubMed  CAS  Google Scholar 

  • Kadiri N, Lagiere M, Le Moine C, Millan MJ, De Deurwaerdere P, Navailles S (2012) Diverse effects of 5-HT(2C) receptor blocking agents on c-Fos expression in the rat basal ganglia. Eur J Pharmacol. doi:10.1016/j.ejphar.2012.05.022

    PubMed  Google Scholar 

  • Kalkman HO, Neumann V, Tricklebank MD (1997) Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol 355(3):361–364

    PubMed  CAS  Google Scholar 

  • Kapur S, Remington G (1996) Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatr 153(4):466–476

    PubMed  CAS  Google Scholar 

  • Kaufman MJ, Hartig PR, Hoffman BJ (1995) Serotonin 5-HT2C receptor stimulates cyclic GMP formation in choroid plexus. J Neurochem 64(1):199–205

    PubMed  CAS  Google Scholar 

  • Kawaguchi Y, Wilson CJ, Augood SJ, Emson PC (1995) Striatal interneurones: chemical, physiological and morphological characterization. Trends Neurosci 18(12):527–535

    PubMed  CAS  Google Scholar 

  • Kenakin T (1995) Agonist-receptor efficacy. II. Agonist trafficking of receptor signals. Trends Pharmacol Sci 16(7):232–238

    PubMed  CAS  Google Scholar 

  • Kennett GA, Curzon G (1988) Evidence that mCPP may have behavioural effects mediated by central 5-HT1C receptors. Br J Pharmacol 94(1):137–147

    PubMed  CAS  Google Scholar 

  • Kennett GA, Wood MD, Glen A, Grewal S, Forbes I, Gadre A, Blackburn TP (1994) In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist. Br J Pharmacol 111(3):797–802

    PubMed  CAS  Google Scholar 

  • Kennett GA, Wood MD, Bright F, Cilia J, Piper DC, Gager T, Thomas D, Baxter GS, Forbes IT, Ham P, Blackburn TP (1996) In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties. Br J Pharmacol 117(3):427–434

    PubMed  CAS  Google Scholar 

  • Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP (1997) SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 36(4–5):609–620

    PubMed  CAS  Google Scholar 

  • Kish SJ, Tong J, Hornykiewicz O, Rajput A, Chang LJ, Guttman M, Furukawa Y (2008) Preferential loss of serotonin markers in caudate versus putamen in Parkinson’s disease. Brain 131(Pt 1):120–131. doi:10.1093/brain/awm239

    PubMed  Google Scholar 

  • Kita H, Chiken S, Tachibana Y, Nambu A (2007) Serotonin modulates pallidal neuronal activity in the awake monkey. J Neurosci 27(1):75–83. doi:10.1523/JNEUROSCI.4058-06.2007

    PubMed  CAS  Google Scholar 

  • Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (2004) Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol 370(2):114–123. doi:10.1007/s00210-004-0951-4

    PubMed  CAS  Google Scholar 

  • Kolomiets BP, Deniau JM, Glowinski J, Thierry AM (2003) Basal ganglia and processing of cortical information: functional interactions between trans-striatal and trans-subthalamic circuits in the substantia nigra pars reticulata. Neuroscience 117(4):931–938

    PubMed  CAS  Google Scholar 

  • Koob GF (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci 13(5):177–184

    PubMed  CAS  Google Scholar 

  • Kostrzewa RM (1995) Dopamine receptor supersensitivity. Neurosci Biobehav Rev 19(1):1–17

    PubMed  CAS  Google Scholar 

  • Kostrzewa RM, Gong L, Brus R (1993) Serotonin (5-HT) systems mediate dopamine (DA) receptor supersensitivity. Acta Neurobiol Exp 53(1):31–41

    CAS  Google Scholar 

  • Kostrzewa RM, Huang NY, Kostrzewa JP, Nowak P, Brus R (2007) Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment. Neurotox Res 11(1):41–50

    PubMed  CAS  Google Scholar 

  • Kuan WL, Zhao JW, Barker RA (2008) The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson’s disease, and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram. Psychopharmacology 197(2):279–293. doi:10.1007/s00213-007-1030-6

    PubMed  CAS  Google Scholar 

  • Kuoppamaki M, Syvalahti E, Hietala J (1993) Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists. Eur J Pharmacol 245(2):179–182

    PubMed  CAS  Google Scholar 

  • Labasque M, Reiter E, Becamel C, Bockaert J, Marin P (2008) Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling. Mol Biol Cell 19(11):4640–4650. doi:10.1091/mbc.E08-04-0422

    PubMed  CAS  Google Scholar 

  • Lagière M, Bosc M, De Deurwaerdère P (2012) The dopaminergic agonist quinpirolee triggers 5-HT2C receptor-dependent controls on both purposeless oral movements and the activity of the hyperdirect pathway in basal ganglia. Front Hum Neurosci Conference Abstract: 4th conference of the Mediterranean Neuroscience Society

  • Lagière M, Navailles S, Mignon L, Roumegous A, Chesselet MF, De Deurwaerdère P (2013a) The enhanced oral response to the 5-HT2 agonist Ro 60–0175 in parkinsonian rats involves the entopeduncular nucleus: electrophysiological correlates. Exp Brain Res. doi:10.1007/s00221-013-3478-4

    Google Scholar 

  • Lagière M, Navailles S, Bosc M, Guthrie G, De Deurwaerdère P (2013b) Serotonin2C receptors and the motor control of oral activity. Curr Neuropharmacol [Epub ahead of print]

  • Leccese AP, Lyness WH (1984) The effects of putative 5-hydroxytryptamine receptor active agents on D-amphetamine self-administration in controls and rats with 5,7-dihydroxytryptamine median forebrain bundle lesions. Brain Res 303(1):153–162

    PubMed  CAS  Google Scholar 

  • Lefkowitz RJ, Cotecchia S, Samama P, Costa T (1993) Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol Sci 14(8):303–307

    PubMed  CAS  Google Scholar 

  • Leggio GM, Cathala A, Moison D, Cunningham KA, Piazza PV, Spampinato U (2009a) Serotonin2C receptors in the medial prefrontal cortex facilitate cocaine-induced dopamine release in the rat nucleus accumbens. Neuropharmacology 56(2):507–513. doi:10.1016/j.neuropharm.2008.10.005

    PubMed  CAS  Google Scholar 

  • Leggio GM, Cathala A, Neny M, Rouge-Pont F, Drago F, Piazza PV, Spampinato U (2009b) In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist. J Neurochem 111(2):614–623. doi:10.1111/j.1471-4159.2009.06356.x

    PubMed  CAS  Google Scholar 

  • Leonhardt S, Gorospe E, Hoffman BJ, Teitler M (1992) Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. Mol Pharmacol 42(2):328–335

    PubMed  CAS  Google Scholar 

  • Leslie RA, Moorman JM, Coulson A, Grahame-Smith DG (1993) Serotonin2/1C receptor activation causes a localized expression of the immediate-early gene c-fos in rat brain: evidence for involvement of dorsal raphe nucleus projection fibres. Neuroscience 53(2):457–463

    PubMed  CAS  Google Scholar 

  • Liminga U, Johnson AE, Andren PE, Gunne LM (1993) Modulation of oral movements by intranigral 5-hydroxytryptamine receptor agonists in the rat. Pharmacol Biochem Behav 46(2):427–433

    PubMed  CAS  Google Scholar 

  • Lobo MK, Karsten SL, Gray M, Geschwind DH, Yang XW (2006) FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains. Nat Neurosci 9(3):443–452. doi:10.1038/nn1654

    PubMed  CAS  Google Scholar 

  • Lopez-Gimenez JF, Mengod G, Palacios JM, Vilaro MT (2001) Regional distribution and cellular localization of 5-HT2C receptor mRNA in monkey brain: comparison with [3H]mesulergine binding sites and choline acetyltransferase mRNA. Synapse 42(1):12–26. doi:10.1002/syn.1095

    PubMed  CAS  Google Scholar 

  • Lucas JJ, Segu L, Hen R (1997) 5-Hydroxytryptamine1B receptors modulate the effect of cocaine on c-fos expression: converging evidence using 5-hydroxytryptamine1B knockout mice and the 5-hydroxytryptamine1B/1D antagonist GR127935. Mol Pharmacol 51(5):755–763

    PubMed  CAS  Google Scholar 

  • Lucas G, De Deurwaerdere P, Caccia S, Umberto S (2000) The effect of serotonergic agents on haloperidol-induced striatal dopamine release in vivo: opposite role of 5-HT(2A) and 5-HT(2C) receptor subtypes and significance of the haloperidol dose used. Neuropharmacology 39(6):1053–1063

    PubMed  CAS  Google Scholar 

  • Mallet N, Ballion B, Le Moine C, Gonon F (2006) Cortical inputs and GABA interneurons imbalance projection neurons in the striatum of parkinsonian rats. J Neurosci 26(14):3875–3884. doi:10.1523/JNEUROSCI.4439-05.2006

    PubMed  CAS  Google Scholar 

  • Manvich DF, Kimmel HL, Howell LL (2012) Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther 341(2):424–434. doi:10.1124/jpet.111.186981

    PubMed  CAS  Google Scholar 

  • Marchese G, Bartholini F, Ruiu S, Casti P, Casu GL, Pani L (2004) Ritanserin counteracts both rat vacuous chewing movements and nigro-striatal tyrosine hydroxylase-immunostaining alterations induced by haloperidol. Eur J Pharmacol 483(1):65–69

    PubMed  CAS  Google Scholar 

  • Marion S, Weiner DM, Caron MG (2004) RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms. J Biol Chem 279(4):2945–2954. doi:10.1074/jbc.M308742200

    PubMed  CAS  Google Scholar 

  • Marquis KL, Sabb AL, Logue SF, Brennan JA, Piesla MJ, Comery TA, Grauer SM, Ashby CR Jr, Nguyen HQ, Dawson LA, Barrett JE, Stack G, Meltzer HY, Harrison BL, Rosenzweig-Lipson S (2007) WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: a novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activity. J Pharmacol Exp Ther 320(1):486–496. doi:10.1124/jpet.106.106989

    PubMed  CAS  Google Scholar 

  • Martin JR, Bos M, Jenck F, Moreau J, Mutel V, Sleight AJ, Wichmann J, Andrews JS, Berendsen HH, Broekkamp CL, Ruigt GS, Kohler C, Delft AM (1998) 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. J Pharmacol Exp Ther 286(2):913–924

    PubMed  CAS  Google Scholar 

  • McCreary AC, Cunningham KA (1999) Effects of the 5-HT2C/2B antagonist SB 206553 on hyperactivity induced by cocaine. Neuropsychopharmacology 20(6):556–564. doi:10.1016/S0893-133X(98)00087-6

    PubMed  CAS  Google Scholar 

  • McGrew L, Chang MS, Sanders-Bush E (2002) Phospholipase D activation by endogenous 5-hydroxytryptamine 2C receptors is mediated by Galpha13 and pertussis toxin-insensitive Gbetagamma subunits. Mol Pharmacol 62(6):1339–1343

    PubMed  CAS  Google Scholar 

  • McMahon LR, Cunningham KA (2001) Antagonism of 5-hydroxytryptamine(2a) receptors attenuates the behavioral effects of cocaine in rats. J Pharmacol Exp Ther 297(1):357–363

    PubMed  CAS  Google Scholar 

  • Mehta A, Eberle-Wang K, Chesselet MF (2001) Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons. Pharmacol Biochem Behav 68(2):347–353

    PubMed  CAS  Google Scholar 

  • Meltzer HY (1993) New drugs for the treatment of schizophrenia. Psychiatr Clin N Am 16(2):365–385

    CAS  Google Scholar 

  • Meltzer HY, Huang M (2008) In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems. Prog Brain Res 172:177–197. doi:10.1016/S0079-6123(08)00909-6

    PubMed  CAS  Google Scholar 

  • Meltzer HY, Nash JF (1991) Effects of antipsychotic drugs on serotonin receptors. Pharmacol Rev 43(4):587–604

    PubMed  CAS  Google Scholar 

  • Meltzer HY, Li Z, Kaneda Y, Ichikawa J (2003) Serotonin receptors: their key role in drugs to treat schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 27(7):1159–1172. doi:10.1016/j.pnpbp.2003.09.010

    PubMed  CAS  Google Scholar 

  • Mengod G, Nguyen H, Le H, Waeber C, Lubbert H, Palacios JM (1990) The distribution and cellular localization of the serotonin 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution. Neuroscience 35(3):577–591

    PubMed  CAS  Google Scholar 

  • Millan MJ (2005) Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie 60(5):441–460

    PubMed  Google Scholar 

  • Millan MJ (2006) Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 110(2):135–370

    PubMed  CAS  Google Scholar 

  • Millan MJ, Dekeyne A, Gobert A (1998) Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo. Neuropharmacology 37(7):953–955

    PubMed  CAS  Google Scholar 

  • Millan MJ, Gobert A, Rivet JM, Adhumeau-Auclair A, Cussac D, Newman-Tancredi A, Dekeyne A, Nicolas JP, Lejeune F (2000) Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram. Eur J Neurosci 12(3):1079–1095

    PubMed  CAS  Google Scholar 

  • Mink JW (1996) The basal ganglia: focused selection and inhibition of competing motor programs. Prog Neurobiol 50(4):381–425

    PubMed  CAS  Google Scholar 

  • Mink JW, Thach WT (1993) Basal ganglia intrinsic circuits and their role in behavior. Curr Opin Neurobiol 3(6):950–957

    PubMed  CAS  Google Scholar 

  • Molineaux SM, Jessell TM, Axel R, Julius D (1989) 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Natl Acad Sci USA 86(17):6793–6797

    PubMed  CAS  Google Scholar 

  • Moorman JM, Leslie RA (1996) P-chloroamphetamine induces c-fos in rat brain: a study of serotonin2A/2C receptor function. Neuroscience 72(1):129–139

    PubMed  CAS  Google Scholar 

  • Mostofsky SH, Simmonds DJ (2008) Response inhibition and response selection: two sides of the same coin. J Cogn Neurosci 20(5):751–761. doi:10.1162/jocn.2008.20500

    PubMed  Google Scholar 

  • Moukhles H, Bosler O, Bolam JP, Vallee A, Umbriaco D, Geffard M, Doucet G (1997) Quantitative and morphometric data indicate precise cellular interactions between serotonin terminals and postsynaptic targets in rat substantia nigra. Neuroscience 76(4):1159–1171

    PubMed  CAS  Google Scholar 

  • Mrini A, Soucy JP, Lafaille F, Lemoine P, Descarries L (1995) Quantification of the serotonin hyperinnervation in adult rat neostriatum after neonatal 6-hydroxydopamine lesion of nigral dopamine neurons. Brain Res 669(2):303–308

    PubMed  CAS  Google Scholar 

  • Murray KC, Nakae A, Stephens MJ, Rank M, D’Amico J, Harvey PJ, Li X, Harris RL, Ballou EW, Anelli R, Heckman CJ, Mashimo T, Vavrek R, Sanelli L, Gorassini MA, Bennett DJ, Fouad K (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16(6):694–700

    PubMed  CAS  Google Scholar 

  • Naidu PS, Kulkarni SK (2001) Effect of 5-HT1A and 5-HT2A/2C receptor modulation on neuroleptic-induced vacuous chewing movements. Eur J Pharmacol 428(1):81–86

    PubMed  CAS  Google Scholar 

  • Nambu A (2008) Seven problems on the basal ganglia. Curr Opin Neurobiol 18(6):595–604

    PubMed  CAS  Google Scholar 

  • Navailles S, De Deurwaerdere P (2011) Presynaptic control of serotonin on striatal dopamine function. Psychopharmacology 213(2–3):213–242

    PubMed  CAS  Google Scholar 

  • Navailles S, De Deurwaerdere P (2012) Imbalanced dopaminergic transmission mediated by serotonergic neurons in L-DOPA-induced dyskinesia. Parkinson’s Dis 2012:323686. doi:10.1155/2012/323686

    Google Scholar 

  • Navailles S, De Deurwaerdère P (2010) The constitutive activity of 5-HT2C receptors as an additional modality of interaction of the serotonergic system in motor control. In: Di Giovanni G, Di Matteo V, Esposito E (eds) 5-HT2C receptors in the pathophysiology of CNS disease. vol The Receptors series. Springer, pp 187–214

  • Navailles S, De Deurwaerdere P, Porras G, Spampinato U (2004) In vivo evidence that 5-HT2C receptor antagonist but not agonist modulates cocaine-induced dopamine outflow in the rat nucleus accumbens and striatum. Neuropsychopharmacology 29(2):319–326. doi:10.1038/sj.npp.1300329

    PubMed  CAS  Google Scholar 

  • Navailles S, De Deurwaerdere P, Spampinato U (2006a) Clozapine and haloperidol differentially alter the constitutive activity of central serotonin2C receptors in vivo. Biol Psychiatry 59(6):568–575

    PubMed  CAS  Google Scholar 

  • Navailles S, Moison D, Ryczko D, Spampinato U (2006b) Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors. J Neurochem 99(4):1311–1319

    PubMed  CAS  Google Scholar 

  • Navailles S, Moison D, Cunningham KA, Spampinato U (2008) Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine. Neuropsychopharmacology 33(2):237–246. doi:10.1038/sj.npp.1301414

    PubMed  CAS  Google Scholar 

  • Navailles S, Benazzouz A, Bioulac B, Gross C, De Deurwaerdere P (2010) High-frequency stimulation of the subthalamic nucleus and L-3,4-dihydroxyphenylalanine inhibit in vivo serotonin release in the prefrontal cortex and hippocampus in a rat model of Parkinson’s disease. J Neurosci 30(6):2356–2364

    PubMed  CAS  Google Scholar 

  • Navailles S, Lagiere M, Roumegous A, Polito M, Boujema MB, Cador M, Dunlop J, Chesselet MF, Millan MJ, De Deurwaerdere P (2013a) Serotonin2C ligands exhibiting full negative and positive intrinsic activity elicit purposeless oral movements in rats: distinct effects of agonists and inverse agonists in a rat model of Parkinson’s disease. Int J Neuropsychopharmacol 1–14. doi:10.1017/S1461145712000417

  • Navailles S, Lagière M, Guthrie M, De Deurwaerdère P (2013b) Serotonin2C receptor constitutive activity: in vivo direct and indirect evidence and functional significance. Cent Nerv Syst Agents Med Chem [Epub ahead of print]

  • Neisewander JL, Acosta JI (2007) Stimulation of 5-HT2C receptors attenuates cue and cocaine-primed reinstatement of cocaine-seeking behavior in rats. Behav Pharmacol 18(8):791–800. doi:10.1097/FBP.0b013e3282f1c94b

    PubMed  CAS  Google Scholar 

  • Nicholson SL, Brotchie JM (2002) 5-hydroxytryptamine (5-HT, serotonin) and Parkinson’s disease - opportunities for novel therapeutics to reduce the problems of levodopa therapy. Eur J Neurol 9(Suppl 3):1–6

    PubMed  Google Scholar 

  • Niswender CM, Copeland SC, Herrick-Davis K, Emeson RB, Sanders-Bush E (1999) RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity. J Biol Chem 274(14):9472–9478

    PubMed  CAS  Google Scholar 

  • North RA, Uchimura N (1989) 5-Hydroxytryptamine acts at 5-HT2 receptors to decrease potassium conductance in rat nucleus accumbens neurones. J Physiol 417:1–12

    PubMed  CAS  Google Scholar 

  • Numan S, Lundgren KH, Wright DE, Herman JP, Seroogy KB (1995) Increased expression of 5HT2 receptor mRNA in rat striatum following 6-OHDA lesions of the adult nigrostriatal pathway. Brain Res Mol Brain Res 29(2):391–396

    PubMed  CAS  Google Scholar 

  • Obeso JA, Rodriguez-Oroz MC, Rodriguez M, Lanciego JL, Artieda J, Gonzalo N, Olanow CW (2000) Pathophysiology of the basal ganglia in Parkinson’s disease. Trends Neurosci 23(10 Suppl):S8–S19

    PubMed  CAS  Google Scholar 

  • Olpe HR, Koella WP (1977) The response of striatal cells upon stimulation of the dorsal and median raphe nuclei. Brain Res 122(2):357–360

    PubMed  CAS  Google Scholar 

  • Pact V, Giduz T (1999) Mirtazapine treats resting tremor, essential tremor, and levodopa-induced dyskinesias. Neurology 53(5):1154

    PubMed  CAS  Google Scholar 

  • Pakhotin P, Bracci E (2007) Cholinergic interneurons control the excitatory input to the striatum. J Neurosci 27(2):391–400. doi:10.1523/JNEUROSCI.3709-06.2007

    PubMed  CAS  Google Scholar 

  • Palacios JM, Waeber C, Hoyer D, Mengod G (1990) Distribution of serotonin receptors. Ann N Y Acad Sci 600:36–52

    PubMed  CAS  Google Scholar 

  • Parent A, Hazrati LN (1995) Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Res Brain Res Rev 20(1):91–127

    PubMed  CAS  Google Scholar 

  • Parry TJ, Eberle-Wang K, Lucki I, Chesselet MF (1994) Dopaminergic stimulation of subthalamic nucleus elicits oral dyskinesia in rats. Exp Neurol 128(2):181–190. doi:10.1006/exnr.1994.1126

    PubMed  CAS  Google Scholar 

  • Pasqualetti M, Ori M, Castagna M, Marazziti D, Cassano GB, Nardi I (1999) Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain. Neuroscience 92(2):601–611

    PubMed  CAS  Google Scholar 

  • Pazos A, Palacios JM (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res 346(2):205–230

    PubMed  CAS  Google Scholar 

  • Pazos A, Hoyer D, Palacios JM (1984) Mesulergine, a selective serotonin-2 ligand in the rat cortex, does not label these receptors in porcine and human cortex: evidence for species differences in brain serotonin-2 receptors. Eur J Pharmacol 106(3):531–538

    PubMed  CAS  Google Scholar 

  • Pazos A, Probst A, Palacios JM (1987) Serotonin receptors in the human brain–III. Autoradiographic mapping of serotonin-1 receptors. Neuroscience 21(1):97–122

    PubMed  CAS  Google Scholar 

  • Peltier R, Schenk S (1993) Effects of serotonergic manipulations on cocaine self-administration in rats. Psychopharmacology 110(4):390–394

    PubMed  CAS  Google Scholar 

  • Pessia M, Jiang ZG, North RA, Johnson SW (1994) Actions of 5-hydroxytryptamine on ventral tegmental area neurons of the rat in vitro. Brain Res 654(2):324–330

    PubMed  CAS  Google Scholar 

  • Picconi B, Bagetta V, Ghiglieri V, Paille V, Di Filippo M, Pendolino V, Tozzi A, Giampa C, Fusco FR, Sgobio C, Calabresi P (2011) Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia. Brain 134(Pt 2):375–387. doi:10.1093/brain/awq342

    PubMed  Google Scholar 

  • Plech A, Brus R, Kalbfleisch JH, Kostrzewa RM (1995) Enhanced oral activity responses to intrastriatal SKF 38393 and m-CPP are attenuated by intrastriatal mianserin in neonatal 6-OHDA-lesioned rats. Psychopharmacology 119(4):466–473

    PubMed  CAS  Google Scholar 

  • Pockros LA, Pentkowski NS, Conway SM, Ullman TE, Zwick KR, Neisewander JL (2012) 5-HT(2A) receptor blockade and 5-HT(2C) receptor activation interact to reduce cocaine hyperlocomotion and Fos protein expression in the caudate-putamen. Synapse 66(12):989–1001. doi:10.1002/syn.21592

    PubMed  CAS  Google Scholar 

  • Politis M, Wu K, Loane C, Quinn NP, Brooks DJ, Oertel WH, Bjorklund A, Lindvall O, Piccini P (2012) Serotonin neuron loss and nonmotor symptoms continue in Parkinson’s patients treated with dopamine grafts. Sci Transl Med 4(128):128ra141. doi:10.1126/scitranslmed.3003391

    Google Scholar 

  • Pompeiano M, Palacios JM, Mengod G (1994) Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res Mol Brain Res 23(1–2):163–178

    PubMed  CAS  Google Scholar 

  • Porras G, Di Matteo V, Fracasso C, Lucas G, De Deurwaerdere P, Caccia S, Esposito E, Spampinato U (2002) 5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum. Neuropsychopharmacology 26(3):311–324. doi:10.1016/S0893-133X(01)00333-5

    PubMed  CAS  Google Scholar 

  • Porrino LJ, Ritz MC, Goodman NL, Sharpe LG, Kuhar MJ, Goldberg SR (1989) Differential effects of the pharmacological manipulation of serotonin systems on cocaine and amphetamine self-administration in rats. Life Sci 45(17):1529–1535

    PubMed  CAS  Google Scholar 

  • Porter RH, Malcolm CS, Allen NH, Lamb H, Revell DF, Sheardown MJ (2001) Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells. Biochem Pharmacol 62(4):431–438

    PubMed  CAS  Google Scholar 

  • Prinssen EP, Balestra W, Bemelmans FF, Cools AR (1994) Evidence for a role of the shell of the nucleus accumbens in oral behavior of freely moving rats. J Neurosci 14(3 Pt 2):1555–1562

    PubMed  CAS  Google Scholar 

  • Prisco S, Esposito E (1995) Differential effects of acute and chronic fluoxetine administration on the spontaneous activity of dopaminergic neurones in the ventral tegmental area. Br J Pharmacol 116(2):1923–1931

    PubMed  CAS  Google Scholar 

  • Prisco S, Pagannone S, Esposito E (1994) Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo. J Pharmacol Exp Ther 271(1):83–90

    PubMed  CAS  Google Scholar 

  • Radja F, Descarries L, Dewar KM, Reader TA (1993) Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain Res 606(2):273–285

    PubMed  CAS  Google Scholar 

  • Ramanathan S, Hanley JJ, Deniau JM, Bolam JP (2002) Synaptic convergence of motor and somatosensory cortical afferents onto GABAergic interneurons in the rat striatum. J Neurosci 22(18):8158–8169

    PubMed  CAS  Google Scholar 

  • Reavill C, Kettle A, Holland V, Riley G, Blackburn TP (1999) Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol 126(3):572–574. doi:10.1038/sj.bjp.0702350

    PubMed  CAS  Google Scholar 

  • Reynolds GP, Templeman LA, Zhang ZJ (2005) The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment. Prog Neuropsychopharmacol Biol Psychiatry 29(6):1021–1028. doi:10.1016/j.pnpbp.2005.03.019

    PubMed  CAS  Google Scholar 

  • Richardson NR, Roberts DC (1991) Fluoxetine pretreatment reduces breaking points on a progressive ratio schedule reinforced by intravenous cocaine self-administration in the rat. Life Sci 49(11):833–840

    PubMed  CAS  Google Scholar 

  • Richtand NM, Welge JA, Logue AD, Keck PE Jr, Strakowski SM, McNamara RK (2008) Role of serotonin and dopamine receptor binding in antipsychotic efficacy. Prog Brain Res 172:155–175. doi:10.1016/S0079-6123(08)00908-4

    PubMed  CAS  Google Scholar 

  • Rick CE, Stanford IM, Lacey MG (1995) Excitation of rat substantia nigra pars reticulata neurons by 5-hydroxytryptamine in vitro: evidence for a direct action mediated by 5-hydroxytryptamine2C receptors. Neuroscience 69(3):903–913

    PubMed  CAS  Google Scholar 

  • Robinson ES, Dalley JW, Theobald DE, Glennon JC, Pezze MA, Murphy ER, Robbins TW (2008) Opposing roles for 5-HT2A and 5-HT2C receptors in the nucleus accumbens on inhibitory response control in the 5-choice serial reaction time task. Neuropsychopharmacology 33(10):2398–2406

    PubMed  CAS  Google Scholar 

  • Rocha BA, Goulding EH, O’Dell LE, Mead AN, Coufal NG, Parsons LH, Tecott LH (2002) Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice. J Neurosci 22(22):10039–10045

    PubMed  CAS  Google Scholar 

  • Rosengarten H, Schweitzer JW, Friedhoff AJ (1999) The effect of novel antipsychotics in rat oral dyskinesia. Prog Neuropsychopharmacol Biol Psychiatry 23(8):1389–1404

    PubMed  CAS  Google Scholar 

  • Rouillard C, Bovetto S, Gervais J, Richard D (1996) Fenfluramine-induced activation of the immediate-early gene c-fos in the striatum: possible interaction between serotonin and dopamine. Brain Res Mol Brain Res 37(1–2):105–115

    PubMed  CAS  Google Scholar 

  • Rueter LE, Tecott LH, Blier P (2000) In vivo electrophysiological examination of 5-HT2 responses in 5-HT2C receptor mutant mice. Naunyn Schmiedebergs Arch Pharmacol 361(5):484–491

    PubMed  CAS  Google Scholar 

  • Rupniak MN, Jenner P, Marsden CD (1983) The effect of chronic neuroleptic administration on cerebral dopamine receptor function. Life Sci 32(20):2289–2311

    PubMed  CAS  Google Scholar 

  • Rupniak NM, Jenner P, Marsden CD (1985) Pharmacological characterisation of spontaneous or drug-associated purposeless chewing movements in rats. Psychopharmacology 85(1):71–79

    PubMed  CAS  Google Scholar 

  • Salamone JD, Mayorga AJ, Trevitt JT, Cousins MS, Conlan A, Nawab A (1998) Tremulous jaw movements in rats: a model of parkinsonian tremor. Prog Neurobiol 56(6):591–611

    PubMed  CAS  Google Scholar 

  • Samad N, Khan A, Perveen T, Haider S, Abdul Haleem M, Haleem DJ (2007) Increase in the effectiveness of somatodendritic 5-HT-1A receptors in a rat model of tardive dyskinesia. Acta Neurobiol Exp 67(4):389–397

    Google Scholar 

  • Schlag BD, Lou Z, Fennell M, Dunlop J (2004) Ligand dependency of 5-hydroxytryptamine 2C receptor internalization. J Pharmacol Exp Ther 310(3):865–870. doi:10.1124/jpet.104.067306

    PubMed  CAS  Google Scholar 

  • Schmauss C (2005) Regulation of serotonin 2C receptor pre-mRNA editing by serotonin. Int Rev Neurobiol 63:83–100. doi:10.1016/S0074-7742(05)63004-8

    PubMed  CAS  Google Scholar 

  • Scholtissen B, Verhey FR, Adam JJ, Weber W, Leentjens AF (2006) Challenging the serotonergic system in Parkinson disease patients: effects on cognition, mood, and motor performance. Clin Neuropharmacol 29(5):276–285. doi:10.1097/01.WNF.0000229013.95927.C7

    PubMed  CAS  Google Scholar 

  • Schotte A, Janssen PF, Gommeren W, Luyten WH, Van Gompel P, Lesage AS, De Loore K, Leysen JE (1996) Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 124(1–2):57–73

    PubMed  CAS  Google Scholar 

  • Sgambato V, Abo V, Rogard M, Besson MJ, Deniau JM (1997) Effect of electrical stimulation of the cerebral cortex on the expression of the Fos protein in the basal ganglia. Neuroscience 81(1):93–112

    PubMed  CAS  Google Scholar 

  • Shen KZ, Johnson SW (2008) 5-HT inhibits synaptic transmission in rat subthalamic nucleus neurons in vitro. Neuroscience 151(4):1029–1033. doi:10.1016/j.neuroscience.2007.12.001

    PubMed  CAS  Google Scholar 

  • Shen KZ, Kozell LB, Johnson SW (2007) Multiple conductances are modulated by 5-HT receptor subtypes in rat subthalamic nucleus neurons. Neuroscience 148(4):996–1003. doi:10.1016/j.neuroscience.2007.07.012

    PubMed  CAS  Google Scholar 

  • Simansky KJ, Dave KD, Inemer BR, Nicklous DM, Padron JM, Aloyo VJ, Romano AG (2004) A 5-HT2C agonist elicits hyperactivity and oral dyskinesia with hypophagia in rabbits. Physiol Behav 82(1):97–107. doi:10.1016/j.physbeh.2004.04.028

    PubMed  CAS  Google Scholar 

  • Singewald N, Salchner P, Sharp T (2003) Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. Biol Psychiatry 53(4):275–283

    PubMed  CAS  Google Scholar 

  • Soghomonian JJ, Descarries L, Watkins KC (1989) Serotonin innervation in adult rat neostriatum. II. Ultrastructural features: a radioautographic and immunocytochemical study. Brain Res 481(1):67–86

    PubMed  CAS  Google Scholar 

  • Stanford IM, Lacey MG (1996) Differential actions of serotonin, mediated by 5-HT1B and 5-HT2C receptors, on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro. J Neurosci 16(23):7566–7573

    PubMed  CAS  Google Scholar 

  • Stanford IM, Kantaria MA, Chahal HS, Loucif KC, Wilson CL (2005) 5-Hydroxytryptamine induced excitation and inhibition in the subthalamic nucleus: action at 5-HT(2C), 5-HT(4) and 5-HT(1A) receptors. Neuropharmacology 49(8):1228–1234

    PubMed  CAS  Google Scholar 

  • Stark JA, Davies KE, Williams SR, Luckman SM (2006) Functional magnetic resonance imaging and c-Fos mapping in rats following an anorectic dose of m-chlorophenylpiperazine. Neuroimage 31(3):1228–1237

    PubMed  Google Scholar 

  • Stark JA, McKie S, Davies KE, Williams SR, Luckman SM (2008) 5-HT(2C) antagonism blocks blood oxygen level-dependent pharmacological-challenge magnetic resonance imaging signal in rat brain areas related to feeding. Eur J Neurosci 27(2):457–465

    PubMed  Google Scholar 

  • Steinbush HW (1984) Serotonin-immunoreactive neurons and their projections in the CNS. In: Björklund A, Hökfelt T, Kuhar MJ (eds) Handbook of chemical neuroanatomy, classical transmitters and transmitter receptors in the CNS, Part II, vol 3. Elsevier, Amsterdam, pp 68–125

    Google Scholar 

  • Steinpreis RE, Baskin P, Salamone JD (1993) Vacuous jaw movements induced by sub-chronic administration of haloperidol: interactions with scopolamine. Psychopharmacology 111(1):99–105

    PubMed  CAS  Google Scholar 

  • Stewart BR, Jenner P, Marsden CD (1989) Induction of purposeless chewing behaviour in rats by 5-HT agonist drugs. Eur J Pharmacol 162(1):101–107

    PubMed  CAS  Google Scholar 

  • Stoessl AJ, Rajakumar N (1996) Effects of subthalamic nucleus lesions in a putative model of tardive dyskinesia in the rat. Synapse 24(3):256–261. doi:10.1002/(SICI)1098-2396(199611)24:3<256:AID-SYN8>3.0.CO;2-D

    PubMed  CAS  Google Scholar 

  • Tan S, Vlamings R, Lim L, Sesia T, Janssen ML, Steinbusch HW, Visser-Vandewalle V, Temel Y (2010) Experimental deep brain stimulation in animal models. Neurosurgery 67(4):1073–1079. doi:10.1227/NEU.0b013e3181ee3580 discussion 1080

    PubMed  Google Scholar 

  • Tarsy D, Baldessarini RJ (1984) Tardive dyskinesia. Annu Rev Med 35:605–623. doi:10.1146/annurev.me.35.020184.003133

    PubMed  CAS  Google Scholar 

  • Tarsy D, Baldessarini RJ, Tarazi FI (2002) Effects of newer antipsychotics on extrapyramidal function. CNS drugs 16(1):23–45

    PubMed  CAS  Google Scholar 

  • Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D (1995) Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374(6522):542–546

    PubMed  CAS  Google Scholar 

  • Temel Y, Blokland A, Steinbusch HW, Visser-Vandewalle V (2005) The functional role of the subthalamic nucleus in cognitive and limbic circuits. Prog Neurobiol 76(6):393–413. doi:10.1016/j.pneurobio.2005.09.005

    PubMed  CAS  Google Scholar 

  • Temel Y, Boothman LJ, Blokland A, Magill PJ, Steinbusch HW, Visser-Vandewalle V, Sharp T (2007) Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus. Proc Natl Acad Sci USA 104(43):17087–17092. doi:10.1073/pnas.0704144104

    PubMed  CAS  Google Scholar 

  • Tilakaratne N, Friedman E (1996) Genomic responses to 5-HT1A or 5-HT2A/2C receptor activation is differentially regulated in four regions of rat brain. Eur J Pharmacol 307(2):211–217

    PubMed  CAS  Google Scholar 

  • Tomkins DM, Joharchi N, Tampakeras M, Martin JR, Wichmann J, Higgins GA (2002) An investigation of the role of 5-HT(2C) receptors in modifying ethanol self-administration behaviour. Pharmacol Biochem Behav 71(4):735–744

    PubMed  CAS  Google Scholar 

  • Tremblay PO, Gervais J, Rouillard C (1998) Modification of haloperidol-induced pattern of c-fos expression by serotonin agonists. Eur J Neurosci 10(11):3546–3555

    PubMed  CAS  Google Scholar 

  • Trent F, Tepper JM (1991) Dorsal raphe stimulation modifies striatal-evoked antidromic invasion of nigral dopaminergic neurons in vivo. Exp Brain Res 84(3):620–630

    PubMed  CAS  Google Scholar 

  • Tsaltas E, Kontis D, Chrysikakou S, Giannou H, Biba A, Pallidi S, Christodoulou A, Maillis A, Rabavilas A (2005) Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology. Biol Psychiatry 57(10):1176–1185. doi:10.1016/j.biopsych.2005.02.020

    PubMed  CAS  Google Scholar 

  • Tsao P, von Zastrow M (2000) Downregulation of G protein-coupled receptors. Curr Opin Neurobiol 10(3):365–369

    PubMed  CAS  Google Scholar 

  • Uchida T, Adachi K, Fujita S, Lee J, Gionhaku N, Cools AR, Koshikawa N (2005) Role of GABA(A) receptors in the retrorubral field and ventral pallidum in rat jaw movements elicited by dopaminergic stimulation of the nucleus accumbens shell. Eur J Pharmacol 510(1–2):39–47. doi:10.1016/j.ejphar.2005.01.012

    PubMed  CAS  Google Scholar 

  • van der Kooy D, Hattori T (1980) Bilaterally situated dorsal raphe cell bodies have only unilateral forebrain projections in rat. Brain Res 192(2):550–554

    PubMed  Google Scholar 

  • Van Oekelen D, Luyten WH, Leysen JE (2003) 5-HT2A and 5-HT2C receptors and their atypical regulation properties. Life Sci 72(22):2429–2449

    PubMed  Google Scholar 

  • Vickers SP, Dourish CT, Kennett GA (2001) Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors. Neuropharmacology 41(2):200–209

    PubMed  CAS  Google Scholar 

  • Waddington JL (1990) Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: phenomenology, pathophysiology and putative relationship to tardive dyskinesia. Psychopharmacology 101(4):431–447

    PubMed  CAS  Google Scholar 

  • Wadenberg ML (1996) Serotonergic mechanisms in neuroleptic-induced catalepsy in the rat. Neurosci Biobehav Rev 20(2):325–339

    PubMed  CAS  Google Scholar 

  • Wadenberg ML, Soliman A, VanderSpek SC, Kapur S (2001) Dopamine D(2) receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects. Neuropsychopharmacology 25(5):633–641. doi:10.1016/S0893-133X(01)00261-5

    PubMed  CAS  Google Scholar 

  • Waeber C, Palacios JM (1989) Serotonin-1 receptor binding sites in the human basal ganglia are decreased in Huntington’s chorea but not in Parkinson’s disease: a quantitative in vitro autoradiography study. Neuroscience 32(2):337–347

    PubMed  CAS  Google Scholar 

  • Waeber C, Palacios JM (1994) Binding sites for 5-hydroxytryptamine-2 receptor agonists are predominantly located in striosomes in the human basal ganglia. Brain Res Mol Brain Res 24(1–4):199–209

    PubMed  CAS  Google Scholar 

  • Waldmeier PC, Delini-Stula AA (1979) Serotonin–dopamine interactions in the nigrostriatal system. Eur J Pharmacol 55(4):363–373

    PubMed  CAS  Google Scholar 

  • Walker PD, Riley LA, Hart RP, Jonakait GM (1991) Serotonin regulation of neostriatal tachykinins following neonatal 6-hydroxydopamine lesions. Brain Res 557(1–2):31–36

    PubMed  CAS  Google Scholar 

  • Ward RP, Dorsa DM (1996) Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum. J Comp Neurol 370(3):405–414

    PubMed  CAS  Google Scholar 

  • Werry TD, Loiacono R, Sexton PM, Christopoulos A (2008) RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function. Pharmacol Ther 119(1):7–23. doi:10.1016/j.pharmthera.2008.03.012

    PubMed  CAS  Google Scholar 

  • Westphal RS, Backstrom JR, Sanders-Bush E (1995) Increased basal phosphorylation of the constitutively active serotonin 2C receptor accompanies agonist-mediated desensitization. Mol Pharmacol 48(2):200–205

    PubMed  CAS  Google Scholar 

  • Willins DL, Meltzer HY (1998) Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens. Brain Res 781(1–2):291–299

    PubMed  CAS  Google Scholar 

  • Willins DL, Berry SA, Alsayegh L, Backstrom JR, Sanders-Bush E, Friedman L, Roth BL (1999) Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo. Neuroscience 91(2):599–606

    PubMed  CAS  Google Scholar 

  • Wilms K, Vierig G, Davidowa H (2001) Interactive effects of cholecystokinin-8S and various serotonin receptor agonists on the firing activity of neostriatal neuronesin rats. Neuropeptides 35(5–6):257–270. doi:10.1054/npep.2001.0875

    PubMed  CAS  Google Scholar 

  • Winstanley CA, Theobald DE, Dalley JW, Glennon JC, Robbins TW (2004) 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion. Psychopharmacology 176(3–4):376–385

    PubMed  CAS  Google Scholar 

  • Wirtshafter D, Cook DF (1998) Serotonin-1B agonists induce compartmentally organized striatal Fos expression in rats. NeuroReport 9(6):1217–1221

    PubMed  CAS  Google Scholar 

  • Wolf WA, Schutz LJ (1997) The serotonin 5-HT2C receptor is a prominent serotonin receptor in basal ganglia: evidence from functional studies on serotonin-mediated phosphoinositide hydrolysis. J Neurochem 69(4):1449–1458

    PubMed  CAS  Google Scholar 

  • Wolf WA, Bieganski GJ, Guillen V, Mignon L (2005) Enhanced 5-HT2C receptor signaling is associated with haloperidol-induced “early onset” vacuous chewing in rats: implications for antipsychotic drug therapy. Psychopharmacology 182(1):84–94

    PubMed  CAS  Google Scholar 

  • Wood MD, Reavill C, Trail B, Wilson A, Stean T, Kennett GA, Lightowler S, Blackburn TP, Thomas D, Gager TL, Riley G, Holland V, Bromidge SM, Forbes IT, Middlemiss DN (2001) SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety. Neuropharmacology 41(2):186–199

    PubMed  CAS  Google Scholar 

  • Wright DE, Seroogy KB, Lundgren KH, Davis BM, Jennes L (1995) Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain. J Comp Neurol 351(3):357–373. doi:10.1002/cne.903510304

    PubMed  CAS  Google Scholar 

  • Xiang Z, Wang L, Kitai ST (2005) Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. J Neurophysiol 93(3):1145–1157

    PubMed  CAS  Google Scholar 

  • Yucel M, Harrison BJ, Wood SJ, Fornito A, Wellard RM, Pujol J, Clarke K, Phillips ML, Kyrios M, Velakoulis D, Pantelis C (2007) Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder. Arch Gen Psychiatry 64(8):946–955. doi:10.1001/archpsyc.64.8.946

    PubMed  CAS  Google Scholar 

  • Zhang Z, Rickard JF, Asgari K, Body S, Bradshaw CM, Szabadi E (2005) Quantitative analysis of the effects of some “atypical” and “conventional” antipsychotics on progressive ratio schedule performance. Psychopharmacology 179(2):489–497. doi:10.1007/s00213-004-2049-6

    PubMed  CAS  Google Scholar 

  • Zhang QJ, Liu X, Liu J, Wang S, Ali U, Wu ZH, Wang T (2009) Subthalamic neurons show increased firing to 5-HT2C receptor activation in 6-hydroxydopamine-lesioned rats. Brain Res 1256:180–189

    PubMed  CAS  Google Scholar 

  • Zhou FC, Bledsoe S, Murphy J (1991) Serotonergic sprouting is induced by dopamine-lesion in substantia nigra of adult rat brain. Brain Res 556(1):108–116

    PubMed  CAS  Google Scholar 

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Acknowledgments

This work was supported by grants from Centre National de la Recherche Scientifique, Bordeaux University and the European Cooperation in Science and Technology (COST action CM1103). Mélanie Lagière is a fellowship recipient from the Ministère de la Recherche et de l’Enseignement Supérieur. We are grateful to Pr Marie-Françoise Chesselet and Dr Laurence Mignon for discussions about some parts of the manuscript.

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  1. Université de Bordeaux, Bordeaux Cedex, France

    P. De Deurwaerdère, M. Lagière, M. Bosc & S. Navailles

  2. Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5293), Université Bordeaux Segalen, 146, rue Léo Saignat, 33076, Bordeaux Cedex, France

    P. De Deurwaerdère, M. Lagière, M. Bosc & S. Navailles

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  1. P. De Deurwaerdère
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Correspondence to P. De Deurwaerdère.

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De Deurwaerdère, P., Lagière, M., Bosc, M. et al. Multiple controls exerted by 5-HT2C receptors upon basal ganglia function: from physiology to pathophysiology. Exp Brain Res 230, 477–511 (2013). https://doi.org/10.1007/s00221-013-3508-2

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