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Parathyroid Hormone (1–34) Attenuates Cartilage Degradation and Preserves Subchondral Bone Micro-architecture in Rats with Patella Baja-Induced-Patellofemoral Joint Osteoarthritis

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Abstract

Several studies have revealed that PTH1-34 may possess the potential for treating osteoarthritis (OA) and osteoporosis. However, no study has yet determined whether PTH1-34 can be used for the treatment of patella baja-induced patellofemoral joint OA (PFJOA). Thus, this study sought to assess the efficacy of PTH1-34 for the treatment of PFJOA in a rat model. Patella baja was induced in 3-month-old female Sprague–Dawley (SD) rats by patellar ligament shortening (PLS), after which the rats were randomly divided into three groups (n = 12): Sham, PLS, and PTH group (PTH + PLS, PTH1-34, 30 µg/kg/d, 5 days per week for 10 weeks). Thereafter, radiographic imaging, macroscopic and microscopic analyses, immunohistochemistry, and microcomputed tomography (CT) analysis were performed. The appearance of PLS-induced PFJOA promoted obvious changes in the patellar position and structure in the PLS group, which were characterized by cartilage degeneration, subchondral bone microstructure deterioration, patella baja, and increasing patella length. However, these negative characteristics were markedly ameliorated by PTH1-34, which not only inhibited cartilage catabolism by decreasing MMP-13 and ADAMTS-4 but also enhanced anabolism by increasing Col-II and Aggrecan. Furthermore, the micro-CT results showed a marked improvement in subchondral bone microarchitecture. The findings presented herein demonstrated that early treatment with PTH1-34 could improve cartilage metabolism and subchondral bone health in this PFJOA model.

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Acknowledgements

The authors express their special thanks to Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.

Funding

This study was supported by the National Natural Science Foundation of China (No. 81874029), Youth Talent Support Program of Hebei Province (JI-2016-10), One-Hundred Innovative Talents Support Fundation of Hebei Province (JJK-2019-14).

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Author notes

  1. Hongfei Zhang and Mingjian Bei contributed equally to this work.

Authors and Affiliations

  1. School of Public Health, North China University of Science and Technology, Bohai Road 21, Caofeidian Dis., Tangshan, 063210, Hebei, People’s Republic of China

    Hongfei Zhang, Qiangqiang Lian, Yudan Wang, Xiaoli Hou & Faming Tian

  2. Department of Orthopedic Surgery, Beijing Ji Shui Tan Hospital, Xinjiekoudongjie 31, Xicheng Dis., Beijing, 100035, People’s Republic of China

    Mingjian Bei

  3. Department of Orthopedic Surgery, The Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei, People’s Republic of China

    Zhiyuan Zheng, Ning Liu, Xuehui Cao & Yaping Xiao

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  1. Hongfei Zhang
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Contributions

HZ, MB and FT designed the study. ZZ, NL, HZ, MB, XC and YX conducted the study and collated the data. QL and YW performed statistical analysis. HZ drafted the manuscript. XH and FT revised manuscript. All authors approved final version.

Corresponding author

Correspondence to Faming Tian.

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Conflict of interest

HZ, MB, ZZ, NL, XC, YX, QL, YW, XH and FT declare that they have no conflict of interest.

Ethical Approval

This study was approved by the local ethics committee at the North China University of Science and Technology.

Human and Animal Rights and Informed Consent

The Micro-CT analysis was performed on the sample collected from rats in this study, and no human sample was used. All the procedures had been approved by the Experimental Animal Ethics Committee of the North China University of North China University of Technology.

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Zhang, H., Bei, M., Zheng, Z. et al. Parathyroid Hormone (1–34) Attenuates Cartilage Degradation and Preserves Subchondral Bone Micro-architecture in Rats with Patella Baja-Induced-Patellofemoral Joint Osteoarthritis. Calcif Tissue Int 111, 87–95 (2022). https://doi.org/10.1007/s00223-022-00958-0

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  • DOI: https://doi.org/10.1007/s00223-022-00958-0

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