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Oxidative stress indicators in Chinese women with PCOS and correlation with features of metabolic syndrome and dependency on lipid patterns

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

The aim was to investigate oxidative stress indicators in the blood of women with PCOS without and with metabolic syndrome (MS) and their dependency on lipids, comparing with healthy women. To our knowledge, this is the first study on this topic.

Methods

This was a cross-sectional study, and blood tests performed were double-blind. Within 3 months, 205 PCOS patients, from whom 55 also had MS, and 65 healthy women (control) were recruited. Malondialdehyde (MDA) was assessed as an important oxidative indicator, and superoxide dismutase (SOD), total antioxidant activity (TAA), vitamin C (VC), vitamin E (VE) and retinol (RET) as antioxidative indicators. Their correlation with features of MS was analyzed including their dependency on lipid pattern.

Results

SOD, TAA, VE and RET in the PCOS group and PCOS + MS group were lower and MDA higher than in the control group (p < 0.05). SOD, VE and RET were the lowest in PCOS + MS group (p < 0.05). Thus, patients in this group had the highest oxidative stress levels but the lowest antioxidative capacity. SOD and TAA significantly decreased with increase of triglycerides (TG) and LDL-C in the PCOS + MS group (p < 0.05), but without dependency on HDL-C. Stepwise multiple linear regression analysis confirmed the different expression of oxidative stress in the three groups and decrease of SOD from control to PCOS group to PCOS + MS group, being associated with an increase of TG.

Conclusions

MS can accelerate the oxidative stress process in patients with PCOS and decrease the antioxidative capacity. The decreased antioxidant capacity in PCOS with MS is related to increased TG and LDL-C.

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Acknowledgements

The authors especially thank Prof. Xingming Li of the Capital Medical University (Beijing, China) for his assistance in statistical analysis of the data.

Funding

This study was supposed by Beijing Municipal Science & Technology Commission (Z161100000516143), Capital’s Funds for Health Improvement and Research (2016-2-2113), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (XMLX201710), Beijing Municipality Health Technology High-level Talent (2014-2-016), Beijing Municipal Administration of Hospitals’ Ascent Plan (DFL20181401).

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Authors and Affiliations

  1. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China

    Husheng Wang, Xiangyan Ruan, Yanglu Li, Jiaojiao Cheng & Alfred O. Mueck

  2. Department of Women’s Health, University Hospitals of Tuebingen, 72076 Tuebingen, Germany

    Xiangyan Ruan & Alfred O. Mueck

Authors
  1. Husheng Wang
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  2. Xiangyan Ruan
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  3. Yanglu Li
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  4. Jiaojiao Cheng
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  5. Alfred O. Mueck
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Contributions

HW: conceptualization: equal, data curation: lead, writing—original draft: lead; XR: conceptualization: lead, data curation: lead, funding acquisition: lead, project administration: lead, supervision: lead, writing—review and editing: lead; YL: data curation: equal; JC: data curation: supporting; AOM: conceptualization: equal, methodology: supporting, supervision: equal, writing—review and editing: lead.

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Correspondence to Xiangyan Ruan.

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Wang, H., Ruan, X., Li, Y. et al. Oxidative stress indicators in Chinese women with PCOS and correlation with features of metabolic syndrome and dependency on lipid patterns. Arch Gynecol Obstet 300, 1413–1421 (2019). https://doi.org/10.1007/s00404-019-05305-7

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  • DOI: https://doi.org/10.1007/s00404-019-05305-7

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