Abstract
The time-dependent inflammatory cell reaction in human cortical contusions has been investigated during the first 30 weeks after blunt head injury. Immunohistochemical staining was carried out using CD 15 for granulocytes and LCA, CD 3 and UCHL-1 for mononuclear leucocytes. In order to provide reliable data for a forensic wound age estimation, the intensity of the cellular reaction was evaluated with a quantitative image analysis system. CD 15-labelled granulocytes were detectable earliest 10 min after brain injury, whereas significantly increased numbers of mononuclear leucocytes occurred in cortical contusions after a postinfliction interval of at least 1.1 days (LCA), 2 days (CD 3) or 3.7 days (UCHL-1), respectively.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 15 June 1998 / Received in revised form: 6 October 1998
Rights and permissions
About this article
Cite this article
Hausmann, R., Kaiser, A., Lang, C. et al. A quantitative immunohistochemical study on the time-dependent course of acute inflammatory cellular response to human brain injury. Int J Leg Med 112, 227–232 (1999). https://doi.org/10.1007/s004140050241
Issue Date:
DOI: https://doi.org/10.1007/s004140050241