Abstract.
The effect of stimulation frequency for pallidal deep brain stimulation in five patients with either generalized or segmental dystonia was evaluated three to twelve months postoperatively via a randomized, double-blind paradigm. The quality of life and the severity of dystonic symptoms improved by approximately 60% and 43% respectively using a frequency of 130 Hz. Compared with 130 Hz a significant further clinical improvement was observed at frequencies of 180 and 250 Hz, which contrasted with a significant deterioration at lower frequencies (5, 50 Hz) compared to 130 Hz.
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Kupsch, A., Klaffke, S., Kühn, A.A. et al. The effects of frequency in pallidal deep brain stimulation for primary dystonia. J Neurol 250, 1201–1205 (2003). https://doi.org/10.1007/s00415-003-0179-0
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DOI: https://doi.org/10.1007/s00415-003-0179-0