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Influence of previous physical activity on the outcome of patients treated by thrombolytic therapy for stroke

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Abstract

Physical activity prevents stroke and is associated with less severe strokes. The neuroprotective effect in patients treated with intravenous (i.v.) recombinant tissue plasminogen activator (rt-PA), remains uncertain. We aimed at evaluating the relationship between previous physical activity and outcomes in stroke patients treated with i.v. rt-PA. OPHELIE-SPORT was a prospective observational multicenter study conducted in French and Japanese stroke patients treated with i.v. rt-PA. We evaluated the presence, weekly duration (<2, 2–5, >5 h) and intensity (light, moderate, heavy) of previous leisure-time physical activity according to standardized criteria. The primary end-point was an excellent outcome [modified Rankin Scale (mRS) 0–1 or similar to the pre-stroke mRS] after 3 months. Secondary end-points were good outcome (mRS 0–2 or similar to the pre-stroke mRS), and death. Of 519 patients, 74 (14.3 %) had regular physical activity before stroke. They were 14 years younger (p < 0.001), treated 25 min earlier (p = 0.004) and more likely to be men, free of pre-stroke handicap (mRS = 0), atrial fibrillation, arterial hypertension, and diabetes mellitus. National Institutes of Health Stroke Scale scores, at baseline (p = 0.183) and 24 h later (p = 0.203), did not differ between patients with and without physical activity. After adjustment on confounders, there was no association between previous leisure-time physical activity and outcome. Outcomes 3 months after treatment of cerebral ischaemia with i.v. rt-PA are not influenced by previous physical activity.

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Acknowledgments

We are grateful to contributors listed below.

Participating centers and contributors are listed. The number of patients recruited per center is given in parentheses.

Lille, France (241) Didier Leys (PI), Charlotte Cordonnier, Hilde Hénon, Marie Bodenant, Nelly Dequatre, Solène Moulin, Costanza Rossi, Dominique Deplanque, Anne-Marie Mendyk, Valentin Vergriete.

Bordeaux, France (166) Igor Sibon (PI), Mathilde Poli, Sharmila Sagnier.

Rennes, France (57) Thomas Ronzière (PI), Veronica Lassalle, Jean François Pinel, Stéphane Vannier, Francoise Kestens.

National Hospital Organization Kyushu Medical Center, Japan (19) Yasushi Okada (PI), Masahiro Yasaka, Yoshinobu Wakisaka, Kei Murao.

Japanese Red Cross Fukuoka Hospital, Japan (15) Kenichirou Fujii.

Amiens, France (10) Olivier Godefroy (PI), Jean Marc Bugnicourt, Sandrine Canaple, Chantal Lamy.

Kawasaki Medical School, Japan (5) Kazumi Kimura.

Steel Memorial Yawata Hospital, Japan (3) Shigeru Fujimoto.

Kyushu Rosai Hospital, Japan (3) Shuji Arakawa.

Author information

Authors and Affiliations

  1. Department of Neurology, Stroke Centre, Lille University Hospital, Lille, France

    Amélie Decourcelle, Solène Moulin, Charlotte Cordonnier & Didier Leys

  2. INSERM U 1171, University of Lille, Lille, France

    Amélie Decourcelle, Solène Moulin, Charlotte Cordonnier, Régis Bordet & Didier Leys

  3. STROKAVENIR Network, 59000, Lille, France

    Amélie Decourcelle, Solène Moulin, Igor Sibon, Thomas Ronzière, Olivier Godefroy, Mathilde Poli, Charlotte Cordonnier, Sharmila Sagnier, Veronica Lassalle, Jean-Louis Mas, Régis Bordet & Didier Leys

  4. Department of Neurology, Stroke Center, University of Bordeaux, Bordeaux, France

    Igor Sibon, Mathilde Poli & Sharmila Sagnier

  5. Department of Cerebrovascular Medicine and Neurology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan

    Kei Murao & Yasushi Okada

  6. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Kei Murao & Yasushi Okada

  7. Department of Neurology, Stroke Unit, University of Rennes, Rennes, France

    Thomas Ronzière & Veronica Lassalle

  8. Department of Neurology, Amiens University Hospital, Amiens, France

    Olivier Godefroy

  9. Department of Neurology, Stroke Centre, Sainte-Anne Hospital, University Paris Descartes, Sorbonne Paris Cité, INSERM UMR S783, Paris, France

    Jean-Louis Mas

  10. Pharmacological Department, Lille University Hospital, Lille, France

    Régis Bordet

Authors
  1. Amélie Decourcelle
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  2. Solène Moulin
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  3. Igor Sibon
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  4. Kei Murao
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  5. Thomas Ronzière
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  6. Olivier Godefroy
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  7. Mathilde Poli
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  8. Charlotte Cordonnier
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  9. Sharmila Sagnier
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  10. Veronica Lassalle
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  11. Yasushi Okada
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  12. Jean-Louis Mas
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  13. Régis Bordet
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  14. Didier Leys
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Corresponding author

Correspondence to Didier Leys.

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Study funding

University Lille 2 (EA 1046), Lille University hospital, ADRINORD, SSHN grant from the French government to Dr. Murao, French Ministry of Health (PHRC STROKAVENIR Network), INSERM and La Revue Neurologique grant to Dr. Murao. Alicante had made available the eCRF for the French part of the study.

Conflicts of interest

Dr. Amélie Decourcelle reports no disclosures. Dr. Solène Moulin reports no disclosures. Dr. Igor Sibon reports no disclosures. Dr. Kei Murao reports no disclosures. Dr. Thomas Ronzière reports grants from Boehringer-Ingelheim. Dr. Olivier Godefroy had partnership with Novartis and Pharnext for trials, speaker at symposia and advisory board meetings. Dr. Mathilde Poli reports no disclosures. Dr. Charlotte Cordonnier had partnership with Boehringer-Ingelheim for trials and speaker at symposia, fees for which were paid towards research at ADRINORD (Association pour le Développement de la Recherche et de l’Innovation dans le Nord-Pas de Calais). Dr. Sharmila Sagnier reports no disclosures. Dr. Veronica Lassalle reports no disclosures. Dr. Yasushi Okada reports no disclosures. Dr. Jean-Louis Mas had partnership with Boehringer-Ingelheim for trials, speaker at symposia and advisory board meetings. Dr. Régis Bordet reports no disclosures. Dr. Didier Leys had partnership with Boehringer-Ingelheim for trials, speaker at symposia and advisory board meetings, fees for which were paid towards research at ADRINORD (Association pour le Développement de la Recherche et de l’Innovation dans le Nord-Pas de Calais).

Ethical standard

The study has been approved by the appropriate ethical committees in France and in Japan, and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All persons, or their close relatives, gave their informed consent prior to their inclusion in the study.

Additional information

On behalf of the OPHELIE-SPORT investigators.

On behalf of the STROKAVENIR network.

OPHELIE-SPORT investigators are listed in Acknowledgments.

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Decourcelle, A., Moulin, S., Sibon, I. et al. Influence of previous physical activity on the outcome of patients treated by thrombolytic therapy for stroke. J Neurol 262, 2513–2519 (2015). https://doi.org/10.1007/s00415-015-7875-4

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  • DOI: https://doi.org/10.1007/s00415-015-7875-4

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