Abstract
Structural deficits in the superior temporal cortex and transverse temporal gyri appear to be related to auditory hallucinations in schizophrenia, which are a key symptom of this disorder. However, the cellular and neurochemical underpinnings are poorly understood and hardly studied in vivo. We used 31P-MRS (magnetic resonance spectroscopy) with chemical shift imaging to assess the association between left superior temporal cortex metabolism and severity of auditory hallucinations in 29 schizophrenia patients off antipsychotics. Hallucinations scores derived from the Scale for the Assessment of Positive Symptoms showed significant positive correlations with both measures of phospholipids (phosphomonoesters and phosphodiesters), and energy (inorganic phosphate and phosphocreatine, but not adenosine tri-phosphate) metabolism in left superior temporal gyrus/Heschl gyrus voxels. There was no correlation of metabolites in these regions with formal thought disorder, a symptom also linked to superior temporal pathology, thus suggesting symptom specificity. Our findings provide a link between established structural deficits and neurochemical pathology related to membrane pathology and markers of general metabolic turnover.
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References
Andreasen NC (1983) The Scale for the Assessment of Negative Symptoms (SANS). The University of Iowa, Iowa City
Andreasen NC (1984) The Scale for the Assessment of Positive Symptoms (SAPS). The University of Iowa, Iowa City
Diederen KM, Daalman K, de Weijer AD, Neggers SF, van Gastel W, Blom JD, Kahn RS, Sommer IE (2012) Auditory hallucinations elicit similar brain activation in psychotic and nonpsychotic individuals. Schizophr Bull 38(5):1074–1082. doi:10.1093/schbul/sbr033
Hugdahl K, Loberg EM, Specht K, Steen VM, van Wageningen H, Jorgensen HA (2007) Auditory hallucinations in schizophrenia: the role of cognitive, brain structural and genetic disturbances in the left temporal lobe. Front Hum Neurosci 1:6. doi:10.3389/neuro.09.006.2007
Hugdahl K, Loberg EM, Nygard M (2009) Left temporal lobe structural and functional abnormality underlying auditory hallucinations in schizophrenia. Front Neurosci 3(1):34–45. doi:10.3389/neuro.01.001.2009
Jardri R, Pouchet A, Pins D, Thomas P (2011) Cortical activations during auditory verbal hallucinations in schizophrenia: a coordinate-based meta-analysis. Am J Psychiatry 168(1):73–81. doi:10.1176/appi.ajp.2010.09101522
Kuhn S, Gallinat J (2012) Quantitative meta-analysis on state and trait aspects of auditory verbal hallucinations in schizophrenia. Schizophr Bull 38(4):779–786. doi:10.1093/schbul/sbq152
Modinos G, Costafreda SG, van Tol MJ, McGuire PK, Aleman A, Allen P (2012) Neuroanatomy of auditory verbal hallucinations in schizophrenia: a quantitative meta-analysis of voxel-based morphometry studies. Cortex. doi:10.1016/j.cortex.2012.01.009
Nenadic I, Smesny S, Schlosser RG, Sauer H, Gaser C (2010) Auditory hallucinations and brain structure in schizophrenia: voxel-based morphometric study. Br J Psychiatry 196(5):412–413. doi:10.1192/bjp.bp.109.070441
Nenadic I, Dietzek M, Langbein K, Rzanny R, Gussew A, Reichenbach JR, Sauer H, Smesny S (2013) Effects of olanzapine on 31P MRS metabolic markers in schizophrenia. Hum Psychopharmacol 28(1):91–93. doi:10.1002/hup.2274
Palaniyappan L, Balain V, Radua J, Liddle PF (2012) Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis. Schizophr Res 137(1–3):169–173. doi:10.1016/j.schres.2012.01.038
Shinn AK, Pfaff D, Young S, Lewandowski KE, Cohen BM, Ongur D (2012) Auditory hallucinations in a cross-diagnostic sample of psychotic disorder patients: a descriptive, cross-sectional study. Compr Psychiatry 53(6):718–726. doi:10.1016/j.comppsych.2011.11.003
Shinn AK, Baker JT, Cohen BM, Ongur D (2013) Functional connectivity of left Heschl’s gyrus in vulnerability to auditory hallucinations in schizophrenia. Schizophr Res 143(2–3):260–268. doi:10.1016/j.schres.2012.11.037
Smesny S, Rosburg T, Nenadic I, Fenk KP, Kunstmann S, Rzanny R, Volz HP, Sauer H (2007) Metabolic mapping using 2D 31P-MR spectroscopy reveals frontal and thalamic metabolic abnormalities in schizophrenia. Neuroimage 35(2):729–737. doi:10.1016/j.neuroimage.2006.12.023
Smesny S, Langbein K, Rzanny R, Gussew A, Burmeister HP, Reichenbach JR, Sauer H (2012) Antipsychotic drug effects on left prefrontal phospholipid metabolism: a follow-up 31P–2D-CSI study of haloperidol and risperidone in acutely ill chronic schizophrenia patients. Schizophr Res 138(2–3):164–170. doi:10.1016/j.schres.2012.02.031
Sun J, Maller JJ, Guo L, Fitzgerald PB (2009) Superior temporal gyrus volume change in schizophrenia: a review on region of interest volumetric studies. Brain Res Rev 61(1):14–32. doi:10.1016/j.brainresrev.2009.03.004
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Nenadic, I., Dietzek, M., Langbein, K. et al. Superior temporal metabolic changes related to auditory hallucinations: a 31P-MR spectroscopy study in antipsychotic-free schizophrenia patients. Brain Struct Funct 219, 1869–1872 (2014). https://doi.org/10.1007/s00429-013-0604-9
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DOI: https://doi.org/10.1007/s00429-013-0604-9