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Hamamelis in children with skin disorders and skin injuries: results of an observational study

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Abstract

Published clinical experience with hamamelis ointment in children is limited. This observational study included children (age 27 days to 11 years) with minor skin injuries, diaper dermatitis, or localized inflammation of skin. The children received either hamamelis ointment or dexpanthenol ointment in groups at a 3-to-1 ratio. Baseline and post-treatment assessments compared the total scores of predefined signs and symptoms for each condition. Physicians and parents were asked for a global assessment of efficacy and tolerability of the respective treatments at the end of therapy. A total of 309 children were treated (hamamelis n = 231; dexpanthenol n = 78). The treatment groups were comparable regarding demographic data and baseline total scores of signs and symptoms. In all three diagnosis groups, the efficacy of hamamelis and dexpanthenol was shown by a statistically significant and clinically relevant decrease of total scores from baseline to endpoint (p < 0.0001 for each group, Wilcoxon signed-rank test). Overall, the results for the hamamelis and the dexpanthenol groups were similar. Descriptive advantages for the hamamelis group were observed for a number of parameters and diagnosis groups. Both treatments were well tolerated. Ratings of the tolerability of hamamelis were “excellent” or “good” in 99.1% (physicians) and 98.2% (parents) of cases, respectively. The corresponding ratings for dexpanthenol were 97.4 and 92.3%. In conclusion, hamamelis ointment is an effective and safe treatment for certain skin disorders in children up to the age of 11 years. The observed effects are similar to dexpanthenol.

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References

  1. National disease and therapeutic index, 1998. IMS Health, Westport, CT

  2. Atherton DJ (2004) A review of the pathophysiology, prevention and treatment of irritant diaper dermatitis. Curr Med Res Opin 20:645–649

    Article  PubMed  Google Scholar 

  3. Bennett JE (2001) Antimicrobial agents (continued). Antifungal agents. In: Hardman JG, Limbaird LE (eds) Goodman & Gilman’s: the pharmaceutical basis of therapeutics. McGraw-Hill, New York, pp 1307–1312

    Google Scholar 

  4. Berg RW (1988) Etiology and pathophysiology of diaper dermatitis. Adv Dermatol 3:75–98

    PubMed  CAS  Google Scholar 

  5. Booth BA, Tan EM, Oikarinen A, Uitto J (1982) Steroid-induced dermal atrophy: effects of glucocorticosteroids on collagen metabolism in human skin fibroblast cultures. Int J Dermatol 21:333–337

    PubMed  CAS  Google Scholar 

  6. Clark C, Hoare C (2001) Making the most of emollients. Pharm J 266:227–279

    Google Scholar 

  7. Concannon P, Gisoldi E, Phillips S, Grossman R (2001) Diaper dermatitis: a therapeutic dilemma. Results of a double-blind placebo-controlled trial of miconazole nitrate 0.25%. Pediatr Dermatol 18:149–155

    Article  PubMed  CAS  Google Scholar 

  8. Dauer A, Metzner P, Schimmer O (1998) Proanthocyanidins from the bark of Hamamelis virginiana exhibit antimutagenic properties against nitroaromatic compounds. Planta Med 64:324–327

    Article  PubMed  CAS  Google Scholar 

  9. DiPetrillo T, Lee H, Cutroneo KR (1984) Anti-inflammatory adrenal steroids that neither inhibit skin collagen synthesis nor cause dermal atrophy. Arch Dermatol 120:878–883

    Article  PubMed  CAS  Google Scholar 

  10. Dohn W (1960) [Contact allergies to antibiotics. Review of the literature.]. Hautarzt 11:433–440

    PubMed  CAS  Google Scholar 

  11. Duwiejua M, Zeitlin IJ, Waterman PG, Gray AI (1994) Anti-inflammatory activity of Polygonum bistorta, Guaiacum officinale and Hamamelis virginiana in rats. J Pharm Pharmacol 46:286–290

    PubMed  CAS  Google Scholar 

  12. Ebner F, Heller A, Rippke F, Tausch I (2002) Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol 3:427–433

    Article  PubMed  Google Scholar 

  13. Erdelmeier CA, Cinatl J Jr, Rabenau H, Doerr HW, Biber A, Koch E (1996) Antiviral and antiphlogistic activities of Hamamelis virginiana bark. Planta Med 62:241–245

    Article  PubMed  CAS  Google Scholar 

  14. Falch B (1999) Hamameliswasser in der Dermatologie. Erfahrungen bei der Behandlung von seborrhoischer, atopischer und nichtatopischer Dermatitis [Hamamelis water in dermatology. Experience in the treatment of seborrhoic, atopic, and non-atopic dermatitis]. Forsch Komplementärmed 6:167–168

    Article  PubMed  CAS  Google Scholar 

  15. Gäbler H (1978) 100 Jahre Hamamelis-Salbe [100 years of Hamamelis ointment]. Dtsch Apoth 30:202–204

    Google Scholar 

  16. Goldstein L (2000) Ask the midwife. Prevention and care of hemorrhoids, including homeopathic remedies. Birth Gaz 16:13–16

    PubMed  CAS  Google Scholar 

  17. Hartisch C, Kolodziej H, von Bruchhausen F (1997) Dual inhibitory activities of tannins from Hamamelis virginiana and related polyphenols on 5-lipoxygenase and lyso-PAF: acetyl-CoA acetyltransferase. Planta Med 63:106–110

    Article  PubMed  CAS  Google Scholar 

  18. Hughes-Formella BJ, Bohnsack K, Rippke F, Benner G, Rudolph M, Tausch I, Gassmueller J (1998) Anti-inflammatory effect of hamamelis lotion in a UVB erythema test. Dermatology 196:316–322

    Article  PubMed  CAS  Google Scholar 

  19. Hughes-Formella BJ, Filbry A, Gassmueller J, Rippke F (2002) Anti-inflammatory efficacy of topical preparations with 10% hamamelis distillate in a UV erythema test. Skin Pharmacol Appl Skin Physiol 15:125–132

    Article  PubMed  CAS  Google Scholar 

  20. Jolibois RP (1976) Etude de l’action d’un onguent à la vitamine B5 sur les affections cutanées du siège du nouveau-né [Study on a vitamin B5 ointment for diaper dermatitis in newborns]. Méd Actuelle 3:6

    Google Scholar 

  21. Korting HC, Schäfer-Korting M, Hart H, Laux P, Schmid M (1993) Anti-inflammatory activity of hamamelis distillate applied topically to the skin. Influence of vehicle and dose. Eur J Clin Pharmacol 44:315–318

    Article  PubMed  CAS  Google Scholar 

  22. Korting HC, Schäfer-Korting M, Klövekorn W, Klövekorn G, Martin C, Laux P (1995) Comparative efficacy of hamamelis distillate and hydrocortisone cream in atopic eczema. Eur J Clin Pharmacol 48:461–465

    Article  PubMed  CAS  Google Scholar 

  23. Leviton I (2003) Separating fact from fiction: the data behind allergies and side effects caused by penicillins, cephalosporins, and carbapenem antibiotics. Curr Pharm Des 9:983–988

    Article  PubMed  CAS  Google Scholar 

  24. Lund C (1999) Prevention and management of infant skin breakdown. Nurs Clin North Am 34:907–920

    PubMed  CAS  Google Scholar 

  25. MacKay D (2001) Hemorrhoids and varicose veins: a review of treatment options. Altern Med Rev 6:126–140

    PubMed  CAS  Google Scholar 

  26. Masaki H, Atsumi T, Sakurai H (1993) Evaluation of superoxide scavenging activities of hamamelis extract and hamamelitannin. Free Radic Res Commun 19:333–340

    PubMed  CAS  Google Scholar 

  27. Pereira da Silva A, Rocha R, Silva CML, Mira L, Duarte MF, Florêncio MH (2000) Antioxidants in medicinal plant extracts. A research study of the antioxidant capacity of Crataegus, Hamamelis and Hydrastis. Phytother Res 14:612–616

    Article  Google Scholar 

  28. Pfister R (1981) Zur Problematik der Behandlung und Nachbehandlung chronischer Dermatosen. Eine klinische Studie über Hametum Salbe [Problems in treatment and follow-up treatment of chronic dermatoses. A clinical study with Hametum ointment]. Fortschr Med 99:1264–1268

    PubMed  CAS  Google Scholar 

  29. Physician’s Desk Reference, PROTOPIC® (tacrolimus) Ointment 0.1% (Fujisawa). 2005

  30. Putet G, Guy B (2000) Etude pilote en ouvert sur l’effet de Bépanthène Onguent dans la prévention des dermites du siège chez les prématurés et les nouveau-nés [An open pilot study on the effects of Bepanthen ointment in the prevention of diaper dermatitis in premature and newborn infants]. Réal Pédiatr 52:659–663

    Google Scholar 

  31. Sorkin B (1980) Hametum Salbe, eine kortikoidfreie antiinflammatorische Salbe [Hametum ointment, a corticoid-free, anti-inflammatory ointment]. Phys Med Reh 21:53–57

    Google Scholar 

  32. Steinhart P (1982) Anorektale Beschwerden: Viele Symptome und was tun? [Ano-rectal complaints: many symptoms and what to do?]. Ärztliche Praxis 34:963–964

    Google Scholar 

  33. Swoboda M, Meurer J (1991) Therapie von Neurodermitis mit Hamamelis-virginiana-Extrakt in Salbenform [Treatment of neurodermatitis with an ointment containing Hamamelis virginiana extract. A double-blind study]. Zeitschr Phytother 12:114–117

    Google Scholar 

  34. Trotter S (2002) Skincare for the newborn: exploring the potential harm of manufactured products. RCM Midwives 5:376–378

    PubMed  Google Scholar 

  35. Welzel J, Walther C, Kieser M, Wolff HH (2005) Hamamelis-Salbe bei trockener Altershaut [Hamamelis ointment for the care of dry aging skin]. Z Phytotherapie 26:6–13

    Article  Google Scholar 

  36. West DP, Worobec S, Solomon LM (1981) Pharmacology and toxicology of infant skin. J Invest Dermatol 76:147–150

    Article  PubMed  CAS  Google Scholar 

  37. Weston WL, Lane AT, Weston JA (1980) Diaper dermatitis: current concepts. Pediatrics 66:532–536

    PubMed  CAS  Google Scholar 

  38. Wilson L (1978) Epidermal thinning atrophy of the skin and topical steroids. Int J Dermatol 17:137–138

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Former Head, Dermatology Department, University Hospital Luebeck, Ratzeburger Allee 160, Bldg. 10, 23552, Luebeck, Germany

    Helmut H. Wolff

  2. Clinical Research Department, Dr. Willmar Schwabe GmbH & Co. KG, Willmar-Schwabe-Str. 4, 76227, Karlsruhe, Germany

    Meinhard Kieser

  3. Thiewall 11, 31840 Hess.-Oldendorf/, Lachem, Germany

    Helmut H. Wolff

Authors
  1. Helmut H. Wolff
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  2. Meinhard Kieser
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Correspondence to Helmut H. Wolff.

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Wolff, H.H., Kieser, M. Hamamelis in children with skin disorders and skin injuries: results of an observational study. Eur J Pediatr 166, 943–948 (2007). https://doi.org/10.1007/s00431-006-0363-1

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  • DOI: https://doi.org/10.1007/s00431-006-0363-1

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