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Exercise improves health-related quality of life sleep and fatigue domains in adult high- and low-grade glioma patients

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Abstract

Purpose

The impact of exercise on health-related quality of life (HRQOL) in patients with glioma remains unknown. We hypothesized that glioma patients with low exercise tolerance experience more distress in HRQOL sleep and fatigue domains than patients with high tolerance to exercise.

Methods

Thirty-eight male and female patients with low- or high-grade glioma treated at a single tertiary care institution participated. Patients completed a validated telephone survey to determine their exercise habits before and following diagnosis. An unpaired t-test was run to measure the interaction between exercise tolerances on HRQOL functional and impairment domains.

Results

Those with low pre-morbid physical activity levels had more distress in HRQOL sleep and fatigue domains. The effects were independent of plasma brain-derived neurotrophic factor (BDNF) levels and the degree of exercise did not appear to impact plasma BDNF in adult glioma patients.

Conclusions

The aim of this study was to examine the significance of exercise habits on perioperative functional outcomes in patients with low-grade or high-grade glioma. We found that glioma patients with low tolerance to exercise had more sleep disturbances and greater fatigue than glioma patients with high tolerance to exercise. Furthermore, exercise tolerance in the adult glioma population does not appear to impact plasma BDNF secretion.

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Data availability

Available upon request.

Code availability

Not applicable.

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Funding

Robert Wood Johnson Foundation, Alfred Taubman Medical Research Institute.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Zachary Miklja, David Altshuler, Lin Wang & Shawn L. Hervey-Jumper

  2. Department of Physical Medicine and Rehabilitation, University of Michigan, 325 E Eisenhower Pkwy, Ste 100, Ann Arbor, MI, USA

    Nicolette Gabel & Sean Smith

Authors
  1. Zachary Miklja
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  2. Nicolette Gabel
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  3. David Altshuler
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  4. Lin Wang
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  5. Shawn L. Hervey-Jumper
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  6. Sean Smith
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Contributions

All authors contributed to the manuscript, including writing and development.

Corresponding author

Correspondence to Sean Smith.

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Approved by institutional review board, HUM00092238.

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All participants provided written consent to participate.

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The authors declare no competing interests.

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Zachary Miklja and Nicolette Gabel are co-first authors.

Shawn L. Hervey-Jumper and Sean Smith co-senior authors.

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Miklja, Z., Gabel, N., Altshuler, D. et al. Exercise improves health-related quality of life sleep and fatigue domains in adult high- and low-grade glioma patients. Support Care Cancer 30, 1493–1500 (2022). https://doi.org/10.1007/s00520-021-06566-2

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  • DOI: https://doi.org/10.1007/s00520-021-06566-2

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