Skip to main content

Advertisement

SpringerLink
Log in

Factors associated with compensatory lung growth after pulmonary lobectomy for lung malignancy: an analysis of lung weight and lung volume changes based on computed tomography findings

  • Original Article
  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

Purpose

To establish the factors associated with compensatory lung growth (CLG) in human adults.

Methods

The subjects of this study were 216 patients who underwent pulmonary lobectomy between January 2008 and March 2015 and had computed tomography (CT) scans done before and 2 years after surgery with no signs of recurrence. The predicted postoperative values of lung volume and lung weight, based on the preoperative CT data, were compared with those 2 years after surgery.

Results

When the predicted postoperative values were considered to be 100%, the mean lung volume and lung weight 2 years after surgery were 116 ± 16% and 115 ± 19%, respectively. CLG was defined as both lung volume ≥ 110% and lung weight ≥ 106% (CLG group; n = 108). Both univariate and multivariate analyses showed that younger age (≤ 60 years), a larger number of resected subsegments (≥ 10), and a light- (< 20 pack-years) or non-smoking history were significantly associated with CLG.

Conclusions

This study identified younger age, a light- or non-smoking history, and a large resection volume as the predictors of CLG in patients who underwent pulmonary lobectomy for lung malignancy. All of these three factors may be reasonably connected to CLG.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Hsia CC. Comparative analysis of the mechanical signals in lung development and compensatory growth. Cell Tissue Res. 2017;367:687–705.

    Article  Google Scholar 

  2. Shikuma K, Chen-Yoshikawa TF, Oguma T, Kubo T, Ohata K, Hamaji M, et al. Radiologic and functional analysis of compensatory lung growth after living-donor lobectomy. Ann Thorac Surg. 2018;105:909–14.

    Article  Google Scholar 

  3. American Thoracic Society. American Thoracic Society Workshop Document. Mechanisms and limits of induced postnatal lung growth. Am J Respir Crit Care Med. 2004;170:319–43.

  4. Butler JP, Loring SH, Patz S, Tsuda A, Yablonskiy DA, Mentzer SJ. Evidence for adult lung growth in humans. N Engl J Med. 2012;367:244–7.

    Article  CAS  Google Scholar 

  5. Mizobuchi T, Chen F, Yoshino I, Iwata T, Yoshida S, Bando T, et al. Radiologic evaluation for volume and weight of remnant lung in living lung donors. J Thorac Cardiovasc Surg. 2013;146:1253–8.

    Article  Google Scholar 

  6. Chen F, Kubo T, Shoji T, Fujinaga T, Bando T, Date H. Comparison of pulmonary function test and computed tomography volumetry in living lung donors. J Heart Lung Transplant. 2011;30:572–5.

    Article  Google Scholar 

  7. Gattinoni L, Caironi P, Pelosi P. What has computed tomography taught us about the acute respiratory distress syndrome? Am J Respir Crit Care Med. 2001;164:1701–11.

    Article  CAS  Google Scholar 

  8. Cigarette smoking and health. American Thoracic Society. Am J Respir Crit Care Med. 1996;153:861–5.

    Article  Google Scholar 

  9. Sobue T, Yamamoto S, Hara M, Sasazuki S, Sasaki S, Tsugane S. Cigarette smoking and subsequent risk of lung cancer by histologic type in middle-aged Japanese men and women: the JPHC study. Int J Cancer. 2002;99:245–51.

    Article  CAS  Google Scholar 

  10. Wang C, Xu J, Yang L, Xu Y, Zhang X, Bai C, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet. 2018;391:1706–17.

    Article  Google Scholar 

  11. Mizobuchi T, Wada H, Sakairi Y, Suzuki H, Nakajima T, Tagawa T, et al. Spirometric and radiological evaluation of the remnant lung long after major pulmonary resection: can compensatory phenomena be recognized in clinical cases? Surg Today. 2014;44:1735–43.

    Article  Google Scholar 

  12. Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48(3):452–8.

    Article  CAS  Google Scholar 

  13. Fehrenbach H, Voswinckel R, Michl V, Mehling T, Fehrenbach A, Seeger W, et al. Neoalveolarisation contributes to compensatory lung growth following pneumonectomy in mice. Eur Respir J. 2008;31:515–22.

    Article  CAS  Google Scholar 

  14. Wang W, Nguyen NM, Guo J, Woods JC. Longitudinal, noninvasive monitoring of compensatory lung growth in mice after pneumonectomy via (3)He and (1)H magnetic resonance imaging. Am J Respir Cell Mol Biol. 2013;49:697–703.

    Article  CAS  Google Scholar 

  15. Ito T, Suzuki H, Wada H, Fujiwara T, Nakajima T, Iwata T, et al. Concordant pattern of radiologic, morphologic, and genomic changes during compensatory lung growth. J Surg Res. 2017;212:60–7.

    Article  Google Scholar 

  16. Doerschuk CM, Sekhon HS. Pulmonary blood volume and edema in postpneumonectomy lung growth in rats. J Appl Physiol. 1990;69:1178–82.

    Article  CAS  Google Scholar 

  17. Ueda K, Tanaka T, Hayashi M, Li TS, Tanaka N, Hamano K. Computed tomography-defined functional lung volume after segmentectomy versus lobectomy. Eur J Cardiothorac Surg. 2010;37:1433–7.

    Article  Google Scholar 

  18. Hsia CC, Herazo LF, Fryder-Doffey F, Weibel ER. Compensatory lung growth occurs in adult dogs after right pneumonectomy. J Clin Invest. 1994;94:405–12.

    Article  CAS  Google Scholar 

  19. Takeda S, Wu EY, Ramanathan M, Estrera AS, Hsia CC. Temporal course of gas exchange and mechanical compensation after right pneumonectomy in immature dogs. J Appl Physiol. 1996;80:1304–12.

    Article  CAS  Google Scholar 

  20. Thurlbeck WM, Galaugher W, Mathers J. Adaptive response to pneumonectomy in puppies. Thorax. 1981;36:424–7.

    Article  CAS  Google Scholar 

  21. Laros CD, Westermann CJ. Dilatation, compensatory growth, or both after pneumonectomy during childhood and adolescence A thirty-year follow-up study. J Thorac Cardiovasc Surg. 1987;93:570–6.

    Article  CAS  Google Scholar 

  22. Thurlbeck WM. Postnatal human lung growth. Thorax. 1982;37:564–71.

    Article  CAS  Google Scholar 

  23. Yoshitomi A, Kuwata H, Suzuki T, Masuda M, Narushima M, Nakajima T, et al. Compensatory growth of residual lung after pneumonectomy in childhood (in Japanese with English abstract). Nihon Kokyuki Gakkai Zasshi. 2000;38:642–4.

    CAS  PubMed  Google Scholar 

  24. Suzuki H, Morimoto J, Mizobuchi T, Fujiwara T, Nagato K, Nakajima T, et al. Does segmentectomy really preserve the pulmonary function better than lobectomy for patients with early-stage lung cancer? Surg Today. 2017;47:463–9.

    Article  CAS  Google Scholar 

  25. Hsia CC, Wu EY, Wagner E, Weibel ER. Preventing mediastinal shift after pneumonectomy impairs regenerative alveolar tissue growth. Am J Physiol Lung Cell Mol Physiol. 2001;281:1279–87.

    Article  Google Scholar 

  26. Takahashi Y, Matsutani N, Morita S, Dejima H, Nakayama T, Uehara H, et al. Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer. Respirology. 2017;22:364–71.

    Article  Google Scholar 

  27. Glénet S, de Bisschop C, Delcambre F, Thiébaut R, Laurent F, Jougon J, et al. No compensatory lung growth after resection in a one-year follow-up cohort of patients with lung cancer. J Thorac Dis. 2017;9:3938–45.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Thoracic Surgery, Tochigi Cancer Center, 4-9-13 Yohnan, Utsunomiya, 320-0834, Tochigi, Japan

    Ikuma Wakamatsu, Haruhisa Matsuguma & Rie Nakahara

  2. Department of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan

    Masayuki Chida

Authors
  1. Ikuma Wakamatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Haruhisa Matsuguma
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rie Nakahara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masayuki Chida
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ikuma Wakamatsu.

Ethics declarations

Conflict of interest

We have no conflicts of interest to declare.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wakamatsu, I., Matsuguma, H., Nakahara, R. et al. Factors associated with compensatory lung growth after pulmonary lobectomy for lung malignancy: an analysis of lung weight and lung volume changes based on computed tomography findings. Surg Today 50, 144–152 (2020). https://doi.org/10.1007/s00595-019-01863-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-019-01863-0

Keywords

Search

Navigation