Abstract
Although hepatitis B virus (HBV) infection is still endemic in Abancay, Peru, two decades after vaccination against hepatitis B started in the area, little is known about the diversity and circulation of genotypes and subgenotypes of the virus. To identify the genotypes and subtypes of HBV circulating in Abancay, complete genome sequences of 11 treatment-naive HBV-infected patients were obtained, and phylogenetic analysis was conducted with these and additional sequences from GenBank. Genotyping revealed the presence of genotype F in all the samples from Abancay. Subgenotype F1b was dominant and only one isolate belonged to subgenotype F4, which represents the first description of this subgenotype in Peru. Phylogenetic analysis revealed that most subgenotype F1b isolates from Peru clustered in a subgroup along with two sequences from Argentina, whereas two clusters with two HBV/F1b sequences each were indicative of recent epidemiological linkage, but only one could be verified by independent data. These results suggest that the HBV subgenotype F1b seems to be the predominant subgenotype in Abancay, Peru.
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This work was supported by the Ministerio de Economía y Competitividad, Spanish Government [project BFU2014-58656-R], and Generalitat Valenciana [project PROMETEO/2016/122].
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The authors have declared that no competing interests exist.
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Written consent was obtained from all patients. The study protocol was approved by the ethics committee of the Centro Superior de Investigación en Salud Pública, Generalitat Valenciana, Spain.
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Handling Editor: Michael A. Purdy.
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Ramírez-Soto, M.C., Bracho, M.A., González-Candelas, F. et al. Genotypes and subgenotypes of hepatitis B virus circulating in an endemic area in Peru. Arch Virol 163, 183–189 (2018). https://doi.org/10.1007/s00705-017-3557-0
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DOI: https://doi.org/10.1007/s00705-017-3557-0