Abstract
This cross-sectional study evaluated the distribution of serum cross-linked C-telopeptides of collagen type I (βCTXs) in postmenopausal women, the characteristics of bone remodeling, and the factors influencing this bone marker, especially the use of anti-osteoporotic drugs. Women (n = 4,175) aged 59–70 years randomly selected from the community were invited to participate, measuring βCTXs and lumbar and femoral bone mineral density at recruitment. Risk factors for osteoporosis and the use of anti-osteoporotic treatment were collected with a structured questionnaire. We evaluated the percentage of women with increased (βCTXs >0.620 ng/mL) and decreased bone turnover (βCTXs <0.100 ng/mL) and those reaching the so-called treatment target (values of βCTXs within the lower half of the reference range for healthy young premenopausal women). Two thousand nine hundred sixty-eight women (70 %) participated (2,405 non-treated and 563 treated). Increased and decreased bone turnover was observed in 16.4 and 1.8 %, respectively, of non-treated women with significant differences compared with treated women (9.7 and 14.2 %, respectively, p < 0.001); 28 % of non-treated osteoporotic individuals had increased bone turnover versus 14 % of osteopenic participants and 8.8 % of women with normal bone density (p < 0.001). Women receiving bisphosphonates presented the highest percentages of decreased bone turnover (27 %) and βCTXs (43 %) within the treatment target. Increased bone turnover is observed in 16.4 % of non-treated postmenopausal women and is more frequent in individuals with osteoporosis, whereas decreased bone turnover is unusual. Most participants taking bisphosphonates had values within the treatment target, but nearly one quarter had decreased bone turnover.
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Acknowledgments
This study was supported by a grant (PI05/1430) from the Spanish “Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III”. Roche Diagnostics kindly provided reagents to determine βCTXs.
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Members of the FRODOS Research Group are given in Appendix.
Appendix: FRODOS Research Group
Appendix: FRODOS Research Group
Dr. Toni Iruela (EAP Centelles), Dr. Xavier Farrés (EAP Vic Sud), Dr. Sara Martínez (CAP Osona), Dr. Maria Vilamú (CAP Manlleu), Dr. Consol Sánchez (CAP Torelló), Dr. Núria de la Iglesia (Consultori Local St Vicenç de Torelló), Dr. Josep Fontarnau (Consultori Local St Pere de Torelló), Dr. Vicenç Canal (CAP Roda de Ter), Dr. Xavier Costa (CAP Tona), Dr. Vicenç Coma (Consultori Local Seva), Dr. Assumpta Farràs (Consultori Local St Miquel de Balenyà), Dr. Lourdes Piñol (CAP St Hipolit de Voltregà), Dr. Rosa Maria Salla (CAP Sta Eugenia de Berga),
Dr. Anna Puente (Consultori Local Taradell), Dr. Marta Cantero (Consultori Local St Julià de Vilatorta), Dr. Carles Blay (Consultori Local Calldetenes), Dr. Anna Ribas (Consultori Local Folgueroles), Dr. Jordi Espinàs (Consultori Local Viladrau), Jordi Oliva (CAP Sta Eugenia de Berga), Dr. Tomàs Morelló (CAP St Quirze de Besora), Dr. Anna Ramos (CAP St Quirze de Besora), Dr. Pere Munt (Consultori de Montesquiu), Dr. Dani Montanyà (Consultori St Boi de Lluçanès), Dr. Josep Mª Garcia Talavera (CAP Prats de Lluçanès), Dr. Raimon Codina (CAP Prats de Lluçanès), Dr. Francesc Olivé (Consultori d’Olost), Dr. Miquel Casadevall (Consultori St Bartomeu del Grau), Judit Solà (Epidemiology Unit-Consorci Hospitalari de Vic).
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Kanterewicz, E., Peris, P., Puigoriol, E. et al. Distribution of serum βCTX in a population-based study of postmenopausal women taking into account different anti-osteoporotic therapies (the FRODOS Cohort). J Bone Miner Metab 31, 231–239 (2013). https://doi.org/10.1007/s00774-012-0410-0
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DOI: https://doi.org/10.1007/s00774-012-0410-0