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Association of Markers of Inflammation with Sleep and Physical Activity Among People Living with HIV or AIDS

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Abstract

This study examined associations of sleep and minutes spent in moderate-vigorous physical activity (MVPA) with C-reactive protein (CRP) and interleukin (IL)-6 among persons living with HIV. Cross-sectional analyses (n = 45) focused on associations of inflammatory outcomes (i.e., CRP and IL-6) with actigraph-derived sleep duration, latency, and efficiency; sleep onset; wake time; and wake-after-sleep-onset; as well as MVPA. Least square means for CRP and IL-6 by levels of sleep and MVPA were computed from general linear models. Individuals below the median of sleep duration, above the median for sleep onset, and below the median of MVPA minutes had higher CRP or IL-6 levels. Generally, individuals with both low MVPA and poor sleep characteristics had higher inflammation levels than those with more MVPA and worse sleep. Understanding the combined impact of multiple lifestyle/behavioral factors on inflammation could inform intervention strategies to reduce inflammation and therefore, chronic disease risk.

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Acknowledgments

We thank all participants who volunteered their time for this project. Drs. Jaggers, Dudgeon, and Hand were supported by an NIH/NINR Grant (1R21NRO11281). Drs. Hand and Blair are supported by unrestricted funding from The Coca-Cola Company. Dr. Hébert is supported by an Established Investigator Award in Cancer Prevention and Control from the Cancer Training Branch of the National Cancer Institute (K05 CA136975). Dr. Youngstedt is supported by an NIH Grant (R01HL095799).

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Correspondence to Michael D. Wirth.

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Wirth, M.D., Jaggers, J.R., Dudgeon, W.D. et al. Association of Markers of Inflammation with Sleep and Physical Activity Among People Living with HIV or AIDS. AIDS Behav 19, 1098–1107 (2015). https://doi.org/10.1007/s10461-014-0949-y

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