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Bone metastasis from glioblastoma: a systematic review

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Abstract

Introduction

Glioblastoma (GBM) is a devastating disease with poor overall survival. Despite the common occurrence of GBM among primary brain tumors, metastatic disease is rare. Our goal was to perform a systematic literature review on GBM with osseous metastases and understand the rate of metastasis to the vertebral column as compared to the remainder of the skeleton, and how this histology would fit into our current paradigm of treatment for bone metastases.

Methods

A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compliant literature search was performed using the PubMed database from 1952 to 2021. Search terms included “GBM”, “glioblastoma”, “high-grade glioma”, “bone metastasis”, and “bone metastases”.

Results

Of 659 studies initially identified, 67 articles were included in the current review. From these 67 articles, a total of 92 distinct patient case presentations of metastatic glioblastoma to bone were identified. Of these cases, 58 (63%) involved the vertebral column while the remainder involved lesions within the skull, sternum, rib cage, and appendicular skeleton.

Conclusion

Metastatic dissemination of GBM to bone occurs. While the true incidence is unknown, workup for metastatic disease, especially involving the spinal column, is warranted in symptomatic patients. Lastly, management of patients with GBM vertebral column metastases can follow the International Spine Oncology Consortium two-step multidisciplinary algorithm for the management of spinal metastases.

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Funding

This work was supported by the National Cancer Institute of the National Institutes of Health under Award Number F32CA254147 to MJS.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA

    Michael J. Strong, Sravanthi Koduri, Oludotun Ogunsola, Timothy J. Yee, Siri Sahib S. Khalsa, Yamaan S. Saadeh, Jacob R. Joseph, Osama N. Kashlan, Paul Park & Mark E. Oppenlander

  2. University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA

    Jodi A. Allison & Cecilia M. Pesavento

  3. Western Michigan University School of Medicine, Kalamazoo, MI, 49008, USA

    Sebele Ogunsola

  4. Department of Neurosurgery, University of Michigan, 3552 Taubman Center, SPC 5338, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109, USA

    Nicholas J. Szerlip

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  1. Michael J. Strong
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  2. Sravanthi Koduri
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  14. Nicholas J. Szerlip
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Contributions

MJS, SK, and NJS generated the concept and design of this manuscript. All authors performed the literature review, analysis, and interpretation. MJS, SK, and NJS drafted the manuscript and generated the tables.

Corresponding author

Correspondence to Nicholas J. Szerlip.

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Conflict of interest

Paul Park reports consultation work with Globus Medical and NuVasive and royalties received from Globus Medical for an unrelated device. Paul Park also reports non-study related research funded by Cerapedics, SI Bone, International Spine Study Group, and Depuy. Mark Oppenlander is a consultant for Globus Medical, DePuy Spine, and LifeNet Health. All other authors have no disclosures.

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Ethical approval was not sought for this systematic review of the literature.

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Strong, M.J., Koduri, S., Allison, J.A. et al. Bone metastasis from glioblastoma: a systematic review. J Neurooncol 158, 379–392 (2022). https://doi.org/10.1007/s11060-022-04025-4

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