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Effect of Variable Doses of Zinc Oxide Nanoparticles on Male Albino Mice Behavior

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Abstract

Zinc oxide nanoparticles (ZnO NPs) have diverse utility these days ranging from being part of nanosensors to be ingredient of cosmetics. Present study was designed to report the effect of variable doses of ZnO NPs on selected aspects of male albino mice behavior. Nano particles were synthesized by sol-gel auto-combustion method (Data not shown here). 10 week old male albino mice were divided into four experimental groups; group A, B and C were orally supplemented with 50 (low dose), 300 (medium dose) and 600 mg/ml solvent/kg body weight (high dose) of ZnO NPs for 4 days. Group D (control) orally received 0.2 M sodium phosphate buffer (solvent for ZnO NPs) for the same duration. A series of neurological tests (Rota rod, open field, novel object and light–dark box test) were conducted in all groups and performance was compared between ZnO NPs treated and control group. Muscular functioning during rota rod test was significantly improved in all ZnO NPs treated mice as compared to control group. While no significant differences in open field, novel object and light–dark box test performance were observed when data from studied parameters of specific ZnO NPs treatment were compared with the control group indicating that applied doses of ZnO NPs did not affect the exploratory, anxiolytic behavior and object recognition capability of adult male albino mice.

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    Authors and Affiliations

    1. Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan

      Javeria Zahra & Muhammad Naeem Ashiq

    2. Institute of Pure and Applied Biology, Zoology Division, Bahauddin Zakariya University, Multan, Pakistan

      Shahid Iqbal, Kiran Zahra, Zulha Javed & Furhan Iqbal

    3. Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan

      Muhammad Aslam Shad

    4. Department of Statistics, Bahauddin Zakariya University, Multan, Pakistan

      Atif Akbar

    Authors
    1. Javeria Zahra
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    2. Shahid Iqbal
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    3. Kiran Zahra
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    4. Zulha Javed
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    5. Muhammad Aslam Shad
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    7. Muhammad Naeem Ashiq
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    Correspondence to Muhammad Naeem Ashiq or Furhan Iqbal.

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    Javeria Zahra and Shahid Iqbal have contributed equally to the manuscript.

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    Zahra, J., Iqbal, S., Zahra, K. et al. Effect of Variable Doses of Zinc Oxide Nanoparticles on Male Albino Mice Behavior. Neurochem Res 42, 439–445 (2017). https://doi.org/10.1007/s11064-016-2090-y

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    • DOI: https://doi.org/10.1007/s11064-016-2090-y

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