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Biomarker testing in advanced non-small-cell lung cancer: a National Consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology

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Abstract

In 2011, the Spanish Society of Medical Oncology and the Spanish Society of Pathology started a joint project to establish recommendations on biomarker testing in patients with advanced non-small-cell lung cancer based on the current evidence. Most of these recommendations are still valid, but new evidence requires some aspects to be updated. Specifically, the recommendation about which biomarkers to test in which patients is being amended, and the best way to manage tumour samples and minimum requirements for biomarker test material are defined. Suitable techniques for testing for epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangement are also reviewed, and a consensus is reached on which situations warrant re-biopsy.

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Acknowledgments

The authors are grateful for the editorial assistance of Ana Martín of HealthCo (Madrid, Spain) in the production of this manuscript. F. López-Ríos thanks B. Angulo and E. Conde for their contribution to lung carcinoma targeted therapies. SEOM and SEAP are grateful for financial support for this project in the form of unrestricted grants from AstraZeneca, Boehringer Ingelheim, Lilly, Novartis, Pfizer and Roche.

Conflict of interest

The authors declare that, when writing and revising the text, they did not know the names of the pharmaceutical companies that provided financial support for this project, so this support has not influenced the content of this article.

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Authors and Affiliations

  1. Department of Medical Oncology, Oncology Service, Hospital Universitari Vall d’Hebron, P. Vall d’Hebron, 119-129, 08035, Barcelona, Spain

    E. Felip

  2. Department of Pathology, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain

    Á. Concha

  3. Department of Medical Oncology, Hospital Universitario La Paz, Madrid, Spain

    J. de Castro

  4. Department of Pathology, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, IDIVAL, Santander, Spain

    J. Gómez-Román

  5. Department of Medical Oncology, Hospital Universitario Ramón y Cajal, Madrid, Spain

    P. Garrido

  6. Department of Pathology, Hospital Clinic, IDIBAPS, CIBERES, Universidad de Barcelona, Barcelona, Spain

    J. Ramírez

  7. Department of Medical Oncology, Hospital Clínico Lozano Blesa, Zaragoza, Spain

    D. Isla

  8. Department of Pathology, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain

    J. Sanz

  9. Department of Medical Oncology, Instituto de Biomedicina de Sevilla, IBIS (Hospital Universitario Virgen del Rocío, Universidad de Sevilla, CSIC), Seville, Spain

    L. Paz-Ares

  10. Laboratorio de Dianas Terapéuticas, Department of Pathology, Hospital Universitario Sanchinarro, Madrid, Spain

    F. López-Ríos

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  1. E. Felip
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Correspondence to E. Felip.

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Felip, E., Concha, Á., de Castro, J. et al. Biomarker testing in advanced non-small-cell lung cancer: a National Consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology. Clin Transl Oncol 17, 103–112 (2015). https://doi.org/10.1007/s12094-014-1248-9

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  • DOI: https://doi.org/10.1007/s12094-014-1248-9

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