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Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor of Trypanosoma cruzi

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Abstract

Chagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator protein is one of the major virulence factors secreted by T. cruzi (TcMIP) in order to infect its host but little is known about its mechanism of action. Studies confer TcMIP an important role in the extracellular matrix transmigration and basal lamina penetration. Here, we report the backbone 1H, 13C, and 15N resonance assignment of TcMIP and the comparison of the secondary structure obtained against reported X-ray crystallography data.

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Acknowledgements

This work was funded by ICGEB early career grant (CRP/PER16-05-EC), Consorcio de Universidades (PIIM-2016), Programa Innóvate Perú del Ministerio de la Producción (203-INNOVATEPERU-EC-2016) and Cienciactiva - CONCYTEC (008-2017-FONDECYT). NMR access to the 800MHz spectrometer was granted by MetaToul (Toulouse metabolomics & fluxomics facilities, www.metatoul.fr) as part of the French National Infrastructure for Metabolomics and Fluxomics MetaboHUBAR- 11-INBS-0010 (www.metabohub.fr), supported by the Région Occitanie, the ERDF, the SICOVAL, and the French Minister of Education & Research.

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Correspondence to Juan M. Lopez.

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The authors declare no conflict of interest.

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Lopez, J.M., Antiparra, R., lippens, G. et al. Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor of Trypanosoma cruzi. Biomol NMR Assign 13, 21–25 (2019). https://doi.org/10.1007/s12104-018-9844-1

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  • DOI: https://doi.org/10.1007/s12104-018-9844-1

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