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PS1 - 6. Cerebral resting-state network changes in patients with type 1 diabetes with and without microangiopathy relate to cognitive functions

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Nederlands Tijdschrift voor Diabetologie Aims and scope

Abstract

Normal cognitive functioning depends on intact connectivity, i.e. communication, within brain networks. This can now be assessed during rest with functional magnetic resonance imaging (fMRI). Examples of such networks are default mode, sensorimotor, visual, attention, auditory and language, and working memory networks. In type 1 diabetes (T1DM) reduced mental efficiency is common, particularly if microangiopathy is present. We tested the hypothesis that cognitive decrements are associated with alterations in neural connectivity during rest, and that these network changes vary, depending on degree of microangiopathy.

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Authors and Affiliations

  1. http://www.bsl.nl

    Jennifer S. ten Kulve, Eelco van Duinkerken, Richard G. IJzerman & Michaela Diamant

  2. Department of Radiology, Anatomy and Neuroscience section, Amsterdam, The Netherlands

    Menno M. Schoonheim, Ernesto J. Sanz-Arigita & Frederik Barkhof

  3. Diabetes Psychology Research Group, Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands

    Eelco van Duinkerken, Martin Klein & Frank J. Snoek

Authors
  1. Jennifer S. ten Kulve
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  2. Eelco van Duinkerken
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  3. Menno M. Schoonheim
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  4. Ernesto J. Sanz-Arigita
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  5. Richard G. IJzerman
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  6. Martin Klein
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  7. Frank J. Snoek
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  8. Frederik Barkhof
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  9. Michaela Diamant
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Corresponding author

Correspondence to Jennifer S. ten Kulve.

Additional information

1Diabetes Center, Department of Internal Medicine; 2Anatomy and Neuroscience section, Department of Radiology; 3Diabetes Psychology Research Group, Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands. E-mail: js.tenkulve@vumc.nl

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ten Kulve, J., van Duinkerken, E., Schoonheim, M. et al. PS1 - 6. Cerebral resting-state network changes in patients with type 1 diabetes with and without microangiopathy relate to cognitive functions. NED. TIJDSCHR. DIABET. 9, 94 (2011). https://doi.org/10.1007/s12467-011-0031-6

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  • DOI: https://doi.org/10.1007/s12467-011-0031-6

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