Abstract
The pleiotropic effect of cytokines has been well documented, but the effects triggered by unique cytokines in different T cell types are still under investigation. The most relevant findings on the influence of interleukin-4 (IL-4) on T cell activation, differentiation, proliferation, and survival of different T cell types are discussed in this review. The main aim of our study was to correlate the observed effect with the corresponding molecular mechanism induced on IL-4/IL-4R interaction, in an effort to understand how the same extracellular stimuli can trigger a wide spectrum of signaling pathways leading to different responses in each T cell type.
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We thank Mr. Shanserley Leite do Espírito Santo and Mr. Mario Luiz da Silva Bandeira (Fundo de Amparo à Pesquisa do Estado do Rio de Janeiro–FAPERJ TCT fellowships) for excellent support.
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Silva-Filho, J.L., Caruso-Neves, C. & Pinheiro, A.A.S. IL-4: an important cytokine in determining the fate of T cells. Biophys Rev 6, 111–118 (2014). https://doi.org/10.1007/s12551-013-0133-z
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DOI: https://doi.org/10.1007/s12551-013-0133-z