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IL-4: an important cytokine in determining the fate of T cells

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Abstract

The pleiotropic effect of cytokines has been well documented, but the effects triggered by unique cytokines in different T cell types are still under investigation. The most relevant findings on the influence of interleukin-4 (IL-4) on T cell activation, differentiation, proliferation, and survival of different T cell types are discussed in this review. The main aim of our study was to correlate the observed effect with the corresponding molecular mechanism induced on IL-4/IL-4R interaction, in an effort to understand how the same extracellular stimuli can trigger a wide spectrum of signaling pathways leading to different responses in each T cell type.

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Acknowledgments

We thank Mr. Shanserley Leite do Espírito Santo and Mr. Mario Luiz da Silva Bandeira (Fundo de Amparo à Pesquisa do Estado do Rio de Janeiro–FAPERJ TCT fellowships) for excellent support.

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Authors and Affiliations

  1. Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, boco C, sala 34, Av. Carlos Chagas Filho 373, 21941-902, Rio de Janeiro, RJ, Brazil

    J. L. Silva-Filho, C. Caruso-Neves & A. A. S. Pinheiro

  2. Instituto Nacional de Ciência e Tecnologia em Biologia e Bioimagem, Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCT, Rio de Janeiro, Brazil

    C. Caruso-Neves

  3. Instituto Nacional para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica, Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCT, Rio de Janeiro, Brazil

    A. A. S. Pinheiro

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  1. J. L. Silva-Filho
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  2. C. Caruso-Neves
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  3. A. A. S. Pinheiro
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Correspondence to A. A. S. Pinheiro.

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Special Issue Advances in Biophysics in Latin America

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Silva-Filho, J.L., Caruso-Neves, C. & Pinheiro, A.A.S. IL-4: an important cytokine in determining the fate of T cells. Biophys Rev 6, 111–118 (2014). https://doi.org/10.1007/s12551-013-0133-z

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