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Cerebral Fractional Flow Reserve for Functional Evaluation of Intracranial Atherosclerotic Stenosis

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References

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Funding

This work was supported by the Natural Science Foundation of Zhejiang Province (Grant No. Y21H090041), the Key Research and Development Project of Zhejiang Provincial Department of Science and Technology (Grant No. 2021C03105), and the Medical Health Science and Technology Project of Zhejiang Provincial Health Commission (Grant No. WKJ-ZJ-2014 and 2020KY133).

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Authors and Affiliations

  1. Brain Center, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, No. 1229 Gudun Road, Hangzhou, 310030, Zhejiang, China

    Ming Wang, Jiong Wu, Yuhai Gao & Shu Wan

  2. ArteryFlow Technology Co., Ltd., Hangzhou, China

    Xiaochang Leng & Jianping Xiang

  3. Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Jens Fiehler

  4. Department of Neurosurgery and Radiology, University at Buffalo, Buffalo, NY, USA

    Adnan H. Siddiqui

  5. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Sravanthi Koduri

Authors
  1. Ming Wang
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  2. Xiaochang Leng
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  3. Jiong Wu
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  4. Yuhai Gao
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  5. Jens Fiehler
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  6. Adnan H. Siddiqui
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  7. Jianping Xiang
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  8. Sravanthi Koduri
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  9. Shu Wan
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Contributions

MW and XCL conceived the project and wrote the paper. SW and JPX conceived and designed the study. JF, AHS, and SK provided a final overview of the paper and revised the manuscript. JW and YHG collected the unpublished data. SW is responsible for the overall content. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Shu Wan.

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Competing Interests

MW, BM, JW, RZ, DL, CZ, YG, NW, YL, and SW declare no competing interests. XL, JX—Stock or stock options: ArteryFlow Technology Co., Ltd. JF receives research support from the German Ministry of Science and Education (BMBF), German Ministry of Economy and Innovation (BMWi), German Research Foundation (DFG), European Union (EU), Hamburgische Investitions- and Förderbank (IFB), Medtronic, Microvention, Philips, Stryker; and serves as a consultant for Acandis, Boehringer Ingelheim, Cerenovus, Evasc Neurovascular, MD Clinicals, Medtronic, Medina, Microvention, Penumbra, Route92, Stryker, Transverse Medical; and serves as an Editorial Board member (Associate Editor) of the Journal of NeuroInterventional Surgery. AHS—Consulting fees: Amnis Therapeutics, Apellis Pharmaceuticals, Inc.; Boston Scientific, Canon Medical Systems USA, Inc.; Cardinal Health 200, LLC; Cerebrotech Medical Systems, Inc.; Cerenovus, Cerevatech Medical, Inc.; Cordis, Corindus, Inc.; Endostream Medical, Ltd.; Imperative Care, Integra, IRRAS AB, Medtronic, MicroVention, Minnetronix Neuro, Inc.; Penumbra, Q’Apel Medical, Inc.; Rapid Medical, Serenity Medical, Inc.; Silk Road Medical, StimMed, LLC; Stryker Neurovascular, Three Rivers Medical, Inc.; VasSol, Viz.ai, Inc.; W.L. Gore & Associates. Leadership or fiduciary role in other board, society, committee or advocacy group: Secretary of the Board of the Society of NeuroInterventional Surgery, Chair of the Cerebrovascular Section of the AANS/CNS. Stock or stock options: Adona Medical, Inc.; Amnis Therapeutics, Bend IT Technologies, Ltd.; BlinkTBI, Inc.; Buffalo Technology Partners, Inc.; Cardinal Consultants, LLC; Cerebrotech Medical Systems, Inc.; Cerevatech Medical, Inc.; Cognition Medical, CVAID Ltd., E8, Inc.; Endostream Medical, Ltd.; Imperative Care, Inc.; Instylla, Inc.; International Medical Distribution Partners, Launch NY, Inc.; NeuroRadial Technologies, Inc.; Neurotechnology Investors, Neurovascular Diagnostics, Inc.; PerFlow Medical, Ltd.; Q’Apel Medical, Inc.; QAS.ai, Inc.; Radical Catheter Technologies, Inc.; Rebound Therapeutics Corp. (Purchased 2019 by Integra Lifesciences, Corp); Rist Neurovascular, Inc. (Purchased 2020 by Medtronic); Sense Diagnostics, Inc.; Serenity Medical, Inc.; Silk Road Medical, Inc.; SongBird Therapy, Spinnaker Medical, Inc.; StimMed, LLC; Synchron, Inc.; Three Rivers Medical, Inc.; Truvic Medical, Inc.; Tulavi Therapeutics, Inc.; Vastrax, LLC; VICIS, Inc.; Viseon, Inc. Other financial or non-financial interests: National PI/Steering Committees: Cerenovus EXCELLENT and ARISE II Trial; Medtronic SWIFT PRIME, VANTAGE, EMBOLISE and SWIFT DIRECT Trials; MicroVention FRED Trial & CONFIDENCE Study; MUSC POSITIVE Trial; Penumbra 3D Separator Trial; COMPASS Trial; INVEST Trial; MIVI neuroscience EVAQ Trial; Rapid Medical SUCCESS Trial; InspireMD C-GUARDIANS IDE Pivotal Trial.

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Wang, M., Leng, X., Wu, J. et al. Cerebral Fractional Flow Reserve for Functional Evaluation of Intracranial Atherosclerotic Stenosis. Transl. Stroke Res. 14, 678–680 (2023). https://doi.org/10.1007/s12975-022-01034-3

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