Serotonergic influences on central respiratory activity: an in vitro study in the newborn rat
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Cited by (86)
Serotonin and substance P: Synergy or competition in the control of breathing
2020, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :It is generally agreed that serotonin is an excitatory modulator of inspiratory activity. This was tested with exogenously applied 5HT in vitro; on rat brainstem-spinal cord preparation (Morin et al., 1990; Morin, 1993; Lindsay and Feldman, 1993), on medullary slices guided to pre-Bötzinger complex (pre-BötC) and raphe obscurus (Al-Zubaidy et al., 1996) and iontophoretically set to NTS in cats (Sessle and Henry, 1985). Selective ligand of 5HT1A receptors (8-OH-DPAT) placed topically on the ventral surface of the medulla in cats induced either rapid, shallow breathing (Gillis et al., 1989), or solely increased respiratory rate (Holtman Jr. and King, 1994).
5-HT neurons and central CO<inf>2</inf> chemoreception
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :In addition, TRH induces bursting pacemaker activity in the NTS (Dekin et al., 1985), and 5-HT induces bursting pacemaker activity in respiratory neurons of the pre-BötC (Ptak et al., 2009), both of which would enhance respiratory output. 5-HT, TRH, and SP also each stimulate respiratory output in the en bloc brainstem-spinal cord preparation of the newborn rat (Morin, Hennequin, Monteau, & Hilaire, 1990; Ptak & Hilaire, 1999; Richerson, 2004). Similarly, there is a large body of data demonstrating that raphé neurons, as well as exogenous 5-HT and TRH receptor agonists stimulate breathing in vivo (Richerson, 2004).
Serotnin as a possible biomarker in obstructive sleep apnea
2016, Sleep Medicine ReviewsCitation Excerpt :Chemosensitive 5-HT neurons stimulate respiration in response to elevations in carbon dioxide levels through activation of motoneurons which control upper airway activity [12]. 5-HT systems also have a role in the autonomic response and arousal from sleep seen in sleep apnea [12–15]. We will review current data on how 5-HT and associated biomarkers have a role in the pathogenesis of OSA and may eventually aid in the diagnosis and treatment of the disease.
5-HT induces enhanced phrenic nerve activity via 5-HT<inf>2A</inf> receptor/PKC mechanism in anesthetized rats
2011, European Journal of PharmacologyNetworks within networks. The neuronal control of breathing
2011, Progress in Brain ResearchCitation Excerpt :In cats, stimulation of raphe pallidus and obscurus (Holtman et al., 1986; Lalley, 1986) increases phrenic discharge amplitude and frequency, whereas they decrease during stimulation of the raphe magnus (Lalley, 1986; Sessle et al., 1981). Similarly, exogenous application of serotonergic agents in vitro has various actions on respiratory activity (Di Pasquale et al., 1992, 1994; Hilaire et al., 1997; Morin et al., 1990; Schwarzacher et al., 2002). In brainstem slices containing the pre-BötC, exogenous application of 5HT2A agonist or blockade of serotonergic reuptake increases inspiratory frequency (Pena and Ramirez, 2002).