Research reportCorticotropin-releasing factor induces a place aversion independent of its neuroendocrine role
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Cited by (63)
Central CRF and acute stress differentially modulate probabilistic reversal learning in male and female rats
2021, Behavioural Brain ResearchCitation Excerpt :However, this neuropeptide and its cognate receptors are also widely expressed in brain regions that reside outside of HPA axis circuitry [25–27]. As a consequence, increased CRF activity in other brain regions can by itself mediate many of the cognitive effects of stress [28–30]. Similar to acute stress, central infusion of exogeneous CRF impairs attention and working memory in male rats [31,32].
The role of pituitary adenylyl cyclase-activating polypeptide in the motivational effects of addictive drugs
2020, NeuropharmacologyCitation Excerpt :However, further studies are needed to identify the site of regulatory action of PACAP. Given that PACAP increases the expression of corticotropin releasing hormone (CRH, also known as CRF) in the paraventricular nucleus (PVN) of the hypothalamus (Agarwal et al., 2005; Grinevich et al., 1997; Stroth et al., 2011) and CRH elicits aversion (Cador et al., 1992) as well as taste aversion (Benoit et al., 2000) in rodents, we hypothesize that PACAP may be acting at the level of PVN to mediate the aversive effects of nicotine. Alternatively, PACAP may be acting in the habenula to alter the aversive effect of nicotine (Fig. 1).
The role of endogenous pituitary adenylyl cyclase activating polypeptide (PACAP) in nicotine self-administration, reward and aversion
2019, Pharmacology Biochemistry and BehaviorCorticotropin-releasing factor in ventromedial prefrontal cortex mediates avoidance of a traumatic stress-paired context
2017, NeuropharmacologyCitation Excerpt :Brain CRF is dysregulated in psychiatric disorders including anxiety disorders, depression, and drug use disorders (George and Koob, 2010). Central administration of CRF increases anxiety-like behaviors and autonomic stress responses (Dunn and Berridge, 1990; Fisher, 1989), and produces conditioned place aversion (Cador et al., 1992). CRF1 receptors (CRFR1) mediate anxiety-like behavior and hyperarousal in stressed rats (Heinrichs and Koob, 2004; Roltsch et al., 2014).
The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction
2016, Progress in Molecular Biology and Translational Science