Individual differences in the psychomotor effects of morphine are predicted by reactivity to novelty and influenced by corticosterone secretion
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2021, Medical EpigeneticsEffects of early-life FGF2 on ultrasonic vocalizations (USVs) and the mu-opioid receptor in male Sprague-Dawley rats selectively-bred for differences in their response to novelty
2019, Brain ResearchCitation Excerpt :The discovery of basal differences in opioid gene expression in bLR and bHR rats may also be of interest because the LR/HR model is commonly used to research individual differences in susceptibility to drug addiction in addition to individual differences in anxiety- and depression-like behavior (Flagel et al., 2010; Piazza et al., 1989). Previous studies using outbred rats with high and low responses to novelty have indicated that HR rats are more sensitive to the psychomotor effects of morphine (Deroche et al., 1993). Since morphine preferentially binds to the mu receptor, our results demonstrating elevated expression of mu receptor expression across multiple affective brain regions, including the nucleus accumbens, may provide insight into differences in drug sensitivity in the HR/LR model.
Individual differences in initial morphine sensitivity as a predictor for the development of opiate addiction in rats
2016, Behavioural Brain ResearchCitation Excerpt :Third, potential biological mechanisms that contribute to the individual differences were not studied. Several potential mechanisms such as the dopamine system [45] and corticosterone stress hormone [14,46] have been previously proposed. Another study reported that mu-opioid receptor mRNA levels in the brain were not different between HR and LR rats [18].
This work was supported by the Institut National de la Santéet de la Recherche Médicale (INSERM), the universitéde Bordeaux II and the Conseil Régional d'Aquitaine.