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Evidence that the 5-HT1A receptor agonists buspirone and ipsapirone activate adrenaline release in the conscious rat

https://doi.org/10.1016/0014-2999(90)90558-NGet rights and content

Abstract

The aim of this study was to investigate the effects of the 5-HT1A receptor agonists buspirone and ipsapirone (1–10 mg/kg) on plasma adrenaline (A) levels and on glycemia in the conscious rat. The results indicate that buspirone was able, within 5 min, to increase plasma A and glucose levels in a dose-dependent manner. Ipsapirone administration triggered similar patterns, except that the highest dose used (10 mg/kg) promoted a time-dependent increase in plasma A and glucose levels that was maximal at the end of analysis.

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    Evidence has accumulated that 5-HT in the central nervous system is also involved in glucose regulation. Selective 5-HT2 agonists cause hyperglycemia in rats (Chaouloff et al., 1990; Sugimoto and Yamada, 2000), and pretreatment with ritanserin or ketanserin prevents the hyperglycemic effects of 5-HT2 agonists. In the present study, however, neither administration of the 5-HT2 receptors antagonist ritanserin nor that of ketanserin affected blood glucose levels, indicating that 5-HT2 receptors were not involved in clozapine-induced hyperglycemia.

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