Short communicationBehavioural and biochemical evidence that glucocorticoids are not involved in DOI-elicited 5-HT2 receptor down-regulation
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Cited by (21)
Tolerance to LSD and DOB induced shaking behaviour: Differential adaptations of frontocortical 5-HT<inf>2A</inf> and glutamate receptor binding sites
2015, Behavioural Brain ResearchCitation Excerpt :In the current work, we address the tolerance phenomenon characteristic for repeated hallucinogen application [for a review see 5, 33, 34]. Tolerance to hallucinogen induced shaking behaviour has often been associated with a downregulation of frontocortical 5-HT2(A) receptors [35–39]. However, mathematical correlations for this receptor-behaviour association, apart from one study on antagonist related regulation of both parameters [40], have not been presented.
Serotonin and the Neuroendocrine Regulation of the Hypothalamic-Pituitary-Adrenal Axis in Health and Disease
2003, Vitamins and HormonesCentral 5-HT<inf>1</inf> and 5-HT<inf>2</inf> binding sites in transgenic mice with reduced glucocorticoid receptor number
2000, Brain ResearchCitation Excerpt :The binding of [125I]DOI to 5-HT2 sites is found to be increased in two hippocampal areas in GR-deficient mice. 5-HT2A and/or 5-HT2C expression, binding, or functions were previously shown to be either left unchanged or increased after ADX [10,13,22,29,30,36]. In contrast to what was observed for 5-HT1A and 5-HT1B receptors, chronic activation of GR — alone or in combination with MR — in different experimental designs also led to either no change or increases in 5-HT2 receptor activity [15,28–30,38,45,59].
The influence of corticosterone on serotonergic stereotypy and sexual behavior in the female rat
1999, Behavioural Brain Research