Elsevier

Life Sciences

Volume 50, Issue 3, 1992, Pages 213-218
Life Sciences

Effects of cocaine on oxygen consumption and mitochondrial respiration in normoxic and hypoxic mice

https://doi.org/10.1016/0024-3205(92)90274-SGet rights and content

Abstract

The administration of cocaine hydrochloride intraperitoneally (25 mg/kg) produces a drop in VO2 in both normoxic and hypoxic mice. The critical PO2 is also decreased and so is the body temperature. The mitochondrial respiration shows a large fall in ST3 and RCR. The addition of cocaine in-vitro to the incubating medium induces changes in the mitochondrial respiration similar to those found after in-vivo administration. This report shows that in addition to its in-vivo actions cocaine alters the respiratory function of the isolated liver mitochondria.

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