Glucose, insulin, and open field responses to immobilization in nonobese diabetic (NOD) mice

doi:10.1016/0031-9384(94)90190-2

Physiology & Behavior

Volume 56, Issue 2, August 1994, Pages 241-246

https://doi.org/10.1016/0031-9384(94)90190-2 Get rights and content

Abstract

Numerous studies have suggested that stress precipitates type I diabetes. Because stress-elicited hyperglycemia may play a role in this effect, we measured the influence of acute immobilization (90 min) upon plasma glucose and insulin levels in nonobese diabetic (NOD) mice, a spontaneous model of type I diabetes. To this end, prediabetic 8-week-old mice of both sexes were compared to age- and sex-matched C57BL/6 control mice. Baseline plasma glucose levels and immobilization-elicited hyperglycemia were both lower in male and female NOD mice compared to their C57BL/6 counterparts. However, the maximal effects of immobilization upon plasma insulin (and corticosterone) levels were not different between NOD and C57BL/6 mice. When subjected to a metabolic stressor, such as 2-deoxyglucose-induced neuroglucopenia, both strains responded with similar increases in plasma glucose levels. This change was associated with hyperinsulinemia, whose amplitude was lower in NOD than in C57BL/6 females. Lastly, administration of the α₂-adrenergic agonist, clonidine, elicited a marked increase in plasma glucose levels, whose amplitude was independent of the strain. The results from this study indicate that the two strains differed in their glycemic response to a psychological, but not to a metabolic, stressor. Because NOD mice were found to exhibit increased locomotion when placed for the first time in an open field, it is suggested that behavioral differences contribute to this differential effect of immobilization upon circulating glucose levels in NOD and C57BL/6 mice.

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In human diabetes, degenerative and functional disorders of the central nervous system, including depression, are common findings. Defective dentate gyrus (DG) neurogenesis is associated with affective-related disorders and depression. We previously demonstrated reduced DG neurogenesis in a pharmacological type 1 diabetes model, the streptozotocin (STZ)-treated mouse. Here, we explored DG neurogenesis in a spontaneous T1D model, the nonobese diabetic (NOD) mouse, at prediabetic and diabetic stages.
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ArticleGlucose, insulin, and open field responses to immobilization in nonobese diabetic (NOD) mice

Abstract

Anim. Behav.

Neuropharmacology

J. Autoimmun.

Psychoendocrinology

Life Sci.

J. Steroid Biochem. Mol. Biol.

Eur. J. Pharmacol.

Brain Res.

Pharmacol. Biochem. Behav.

Metabolism

Clin. Immunol. Immunopathol.

Neuropharmacology

Group size, cage shelf level, and emotionality in non-obese diabetic mice: Impact on onset and incidence of IDDM

Psychosom. Med.

Pharmacological characterization of the hyperglycemia induced by alpha-2 adrenoceptor agonists

J. Pharmacol. Exp. Ther.

Corticosterone response to the serotonergic agonist D-fenfluramine may be independent from corticotropin-releasing factor (CRF)

Neurosci. Lett.

Psychophysiological aspects of the management of diabetes mellitus

Int. J. Ment. Health

Effects of 2-deoxyglucose on carbohydrate metabolism: Review of the literature and studies in the rat

Metabolism

Effect of stress on blood glucose in IDDM

Diabetes Care

Behavior, stress, and lymphocyte recirculation

Mechanisms involved in the hyperglycemic response induced by clonidine and other alpha-2 adrenoceptor agonists

J. Pharmacol. Exp. Ther.

Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein

Anterior pituitary gland

The glycemic effects of sympathomimetics in stressed mice

Res. Commun. Chem. Pathol. Pharmacol.

Article
Glucose, insulin, and open field responses to immobilization in nonobese diabetic (NOD) mice