Acetylcholine and central chemosensitivity: in vitro study in the newborn rat
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Effects of acetylcholine on hypoglossal and C4 nerve activity in brainstem-spinal cord preparations from newborn rat
2021, Respiratory Physiology and NeurobiologyCitation Excerpt :As cholinergic neurons are mainly located outside the level of the slices (Picciotto et al., 2012; Ruggiero et al., 1990; Woolf, 1991), the remaining axons or terminals can still release ACh in the preBötC and XII nucleus. Consistent results were also obtained in experiments with brainstem-spinal cord preparation from newborn rats (Monteau et al., 1990; Wollman et al., 2016). Thus, activity of the choline acetyltransferase in newborn rat brain seems to be enough to show physiological function in the medulla.
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2012, Seldin and Giebisch's The Kidney: Physiology and PathophysiologyM3-receptor activation counteracts opioid-mediated apneusis, but the apneusis per se is not necessarily related to an impaired M3 mechanism in rats
2011, Life SciencesCitation Excerpt :Further, it has been demonstrated that respiratory neurons receive muscarinic excitatory synaptic drives during hypercapnia (Takeda and Haji, 1991). The muscarinic receptor-mediated excitatory responses may agree with the result that ACh is involved in the respiratory neuronal excitation induced by CO2 (Monteau et al., 1990). It is generally accepted that opioids depress the chemosensitive neuronal pathways associated with the central response to hypercapnia (Pokorski et al., 1981).
Anandamide centrally depresses the respiratory rhythm generator of neonatal mice
2010, NeuroscienceCitation Excerpt :The central mechanisms through which AEA activation of CB1R affects the RRG are probably complex. AEA requires more than 5 min to significantly depress the RRG whereas NA, serotonin or acetylcholine affects the RRG within 1–2 min (Cayetanot et al., 2001; Monteau et al., 1990; Zanella et al., 2006). The latency of the effects of AEA suggests a special mode of action of the CB1R.
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