Characterization of Ca2+ signals generated by extracellular nucleotides in supporting cells of the organ of Corti
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Cited by (80)
Targeted single-cell electroporation loading of Ca<sup>2+</sup> indicators in the mature hemicochlea preparation
2019, Hearing ResearchCitation Excerpt :Although the hemicochlea (Edge et al., 1998; Richter et al., 1998) lacks the normal hydrodynamic properties and amplification of the cochlea, the preparation provides several advantages for investigations: i) it sustains the delicate cytoarchitecture of the organ of Corti, ii) allows tonotopic experimental approach on the radial perspective of the organ in the basal, middle and apical turns, and iii) provides all of these in a preparation from hearing mice (>P15; Ehret, 1976). Cell cultures of certain cochlear cell types or acutely isolated cells (Ashmore and Ohmori, 1990; Dulon et al., 1993) do not preserve the special microenvironment and intercellular communication in the organ of Corti. Cochlear explants lack some of these disadvantages, but in their case a restricted portion of the organ of Corti is excised from its environment (Chan and Rouse, 2016; Moser and Beutner, 2000).
Purinergic signaling in special senses
2009, Trends in NeurosciencesCitation Excerpt :Hensen's body, an Ins(1,4,5)P3-receptor-gated Ca2+ store under the cuticular plate, is activated by this P2Y receptor signaling via liberation of a G protein in the hair bundle, and the localized elevation in Ca2+ probably alters actin binding, affecting stereocilia stiffness [115]. P2-receptor-mediated Ca2+ signaling within Deiters’ cells, originating in the apical phalangeal process that projects to the reticular lamina between the outer hair-cell cuticular plates, causes changes in the stiffness of the cells that would affect transduction [116–118]. Overall, purinergic signaling in the cochlear partition can be viewed as a protective adaptation mechanism.
Postnatal development of the organ of Corti in dominant-negative Gjb2 transgenic mice
2008, NeuroscienceCitation Excerpt :ATP is known to act as trophic factor, mitogen and potent neuromodulator (Fields and Burnstock, 2006; Nedergaard et al., 2003). Since supporting cells express ATP receptors (Dulon et al., 1993), the same scenario is likely to occur in an adapted form with the organ of Corti. The supporting cells may have an influence on maturation, cell volume and cell shape at least through the polymerization of microtubules by activated by ATP in an autocrine and paracrine manner (Zhao et al., 2005).
Supporting Cells–a New Area in Cochlear Physiology Study
2008, Journal of OtologyCitation Excerpt :Identified as a neuromodulater or neurotransmitter2, 19, 20, ATP exerts its effects mainly through P2 purinergic receptors. Studies showed that ATP can induce Potassium current on Hensen’s cells 21, elevate the concentration of free calcium in the inner and outer hair cells 5, 22–26, and also stimulate Ca2 + release from internal stores in Deiters’ cells (but not in Hensen’s cells27). ATP mobilized Ca2 + from the phalanges of Deiters’ cells, which then propagated towards the cell body as a wave, suggestisng presence of purinergic receptors in the phalanges.