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Neostriatal dopamine receptors

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    Despite the success of the classical BG model in providing a predictive framework for interpreting several patterns of data across multiple levels of analysis, there have been several challenges to the basic tenets of the model. First, the model relies on the segregation of D1 and D2 receptors in striatonigral and striatopallidal neurons [65–67,20,97,84,8]. Earlier challenges suggested that, in fact, D1 and D2 receptors are co-localized on the same neurons, even if this co-localization is small relative to the overall expression of one or the other receptor type [159,1].

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