Research reportAdrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide
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Glucocorticoids and COVID-19
2022, Pharmacological ResearchStressors affect urocortin 1 and urocortin 2 gene expression in rat spleen: The role of glucocorticoids
2019, Journal of NeuroimmunologyCitation Excerpt :Withdrawal of glucocorticoids led to a significant increase of IL-1β and TNF-α mRNA levels and increase of IL-6 mRNA levels after immobilization when compared to stressed animals with intact adrenals (Sham). These results are in accordance with data obtained from experiments in which animals that underwent surgical adrenalectomy were exposed to either a stressor (foot-shock) or inflammatory stimulus (LPS) and suggests an inhibitory role of acute stress on cytokine production in the spleen, with a role of glucocorticoids as anti-inflammatory factor (Goujon et al., 1996; Meltzer et al., 2003, 2004). Our results have shown that acute physical-psychological stress (IMO) is not a very potent activator of the splenic immune response when compared to a classical immune challenge induced by LPS.
Critical Roles of Endogenous Glucocorticoids for Disease Tolerance in Malaria
2019, Trends in ParasitologyEndothelial immunocytochemical expression of pituitary IL-1β and its relation to ACTH-positive cells is regulated by corticosterone in the male rat
2017, CytokineCitation Excerpt :Concerning the regulation of the HPA axis, IL-1β stimulates the secretion of POMC derivatives thus promoting the release of ACTH [16,19–21]. Indeed, the relationship between the hypophyseal IL-1β and the HPA axis follows a bidirectional feedback pattern [5,6,22], including the notorious influence regarding the time course, and correlation with an autocrine-paracrine regulation at the pituitary level [12,23]; although, some aspects concerning the cellular characteristics or local variations still remain unknown. The question of how this network implicates both the pituitary IL-1β and the HPA axis, considering their bidirectional autocrine-paracrine regulation and their participation in the maintenance of populations of relevant cellular elements involved in these processes, has been of particular interest in our own research [17,18,24].