A comparison of the working memory performances of young and aged mice combined with parallel measures of testing and drug-induced activations of septo-hippocampal and nbm-cortical cholinergic neurones
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An update on the cognitive impact of clinically-used hormone therapies in the female rat: Models, mazes, and mechanisms
2013, Brain ResearchCitation Excerpt :In animals, age-related spatial deficits become more pronounced as memory demand increases as well. This has been shown for age-associated interference-related deficits (Lebrun et al., 1990) and for memory capacity deficits (Aggleton et al., 1989; Bimonte-Nelson et al., 2003, 2004b; Bimonte et al., 2003). In general, working memory is distinguished from reference memory, which is necessary to remember information that remains constant over time (task-specific information, for discussion see Olton et al., 1979).
Assessment of spatial memory in mice
2010, Life SciencesCitation Excerpt :The other advantage is that this test induces only a moderate level of stress (Hodges 1996). The radial maze has also been used to study age-related cognitive decline in various mouse models (Bernstein et al. 1985; Krazem et al. 2003; Lebrun et al. 1990; Lohmann and Riepe 2007; Marighetto et al. 2000; Nogues et al. 1996; Takahashi et al. 2009; Touyarot et al. 2002; Touzani et al. 2003). It has been suggested that mice use several types of information for task performance and as they mature they turn more often to distal cues for orientation (Chapillon et al. 1995).
Cholinergic system, rearing environment and trajectory learning during aging in mice
2007, Physiology and BehaviorCitation Excerpt :Spatial learning and memory alterations occur in aged humans [1–3] as well as in aged laboratory rodents [4–9]. Such dysfunctions have been correlated with functional or/and morphological changes in cholinergic structures in the central nervous system, such as the hippocampus [10], the dentate gyrus [11–13], the septal area [14], the septo-hippocampal system [15,16] and the basal forebain [10,17]. Moreover, there is evidence that deficits of spatial memory during aging are reduced, at least in part, by restoration of the cholinergic system functioning [18].
Models of anxiety: Responses of rats to novelty in an open space and an enclosed space
2006, Behavioural Brain ResearchCitation Excerpt :Many laboratories around the world have been using the radial maze and the T-maze for assessing working memory [58,12,29,160,143,129,128,187] without raising comparable concerns as seen with the current models of anxiety. Our laboratory and others have used the radial maze for several years on flat open-arms with or without small ledges, and the results from lesions and drug studies were comparable to those using enclosed radial maze arms [52,54,53,99,97]. The strains of rats or mice and type of treatment have not been a major issue and were easily discernable.
Aging and subcellular localization of m2 muscarinic autoreceptor in basalocortical neurons in vivo
2005, Neurobiology of AgingInteractions between aging and cortical cholinergic deafferentation on attention
2002, Neurobiology of Aging