Intracerebral dopaminergic transplants are not activated by electrical footshock stress activating in situ mesocorticolimbic neurons☆
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Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis
2009, NeuropharmacologyCitation Excerpt :Thus the NAc is involved in a complex integration of excitatory glutamate inputs, sometimes excitatory dopamine (D1-like) inputs, and sometimes inhibitory dopamine (D2-like) inputs. Considering that VTA tends to a have uniform response–activation to both rewarding (e.g., morphine; see Di Chiara and Imperato, 1988; Leone et al., 1991; Johnson and North, 1992) and aversive (Dunn, 1988; Herman et al., 1988; Kalivas and Duffy, 1989; McFarland et al., 2004) stimuli, the ability of the NAc to integrate these excitatory and inhibitory signals downstream of mesolimbic dopamine neurons likely plays a key role in attaching valence and regulating mood. It is well accepted that the NAc plays a key role in reward.
Dynamic regulation of striatal dopaminergic grafts during locomotor activity
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This work was supported by grants from MRT (85.C.1143) and the Conseil Régional d'Aquitaine.
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Antibodies directed against tyrosine hydroxylase were generously donated by A. Vigny (Paris). The expert secretarial help of Ms. M. Thamptham and technical assistance of Mr. J.M. Claustrat is gratefully acknowledged.