Elsevier

Neuroscience Letters

Volume 116, Issue 3, 24 August 1990, Pages 299-303
Neuroscience Letters

Depressant effect of raphe stimulation on inspiratory activity of the hypoglossal nerve: In vitro study in the newborn rat

https://doi.org/10.1016/0304-3940(90)90090-VGet rights and content

Abstract

Respiratory activity was recorded from the hypoglossal nerve and cervical ventral roots of the superfused isolated brainstem and spinal cord of the newborn rat in order to investigate the effects of serotonin (5-HT). Three experimental procedures were used: (i) brainstem superfusion by exogenous 5-HT (previously reported), (ii) electrical stimulation of pontine midline structures, and (iii) pressure microejection of l-glutamate at the same sites. Each of the experimental procedure increased respiratory frequency and depressed the amplitude of the discharge of the hypoglossal nerve more than that of the cervical roots. These results indicate that 5-HT acts centrally to modulate the activity of the respiratory generator and inhibits the hypoglossal activity. A possible involvement of 5-HT mediated inhibition in obstructive apnea is discussed.

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