Responses of substantia nigra pars reticulata and globus pallidus complex to high frequency stimulation of the subthalamic nucleus in rats: electrophysiological data

doi:10.1016/0304-3940(95)11455-6

Neuroscience Letters

Volume 189, Issue 2, 14 April 1995, Pages 77-80

https://doi.org/10.1016/0304-3940(95)11455-6 Get rights and content

Abstract

High frequency stimulation of the subthalamic nucleus (STN-HFS) has been shown to reverse parkinsonian motor symptoms in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. We have studied the effect of STN-HFS on the spontaneous activity of the substantia nigra pars reticulata (SNr), entopeduncular nucleus (EP) and globus pallidus (GP) in rats. STN-HFS induced a decrease in activity of 91% of SNr cells, a suppression of activity in 80% of EP cells and an activation of 100% of GP recorded cells. These results show that STN-HFS exerts an inhibitory influence on the basal ganglia output structures similar to that obtained by STN lesion.

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Citation Excerpt :
In (Saenger et al., 2017), the thalamus shows one of the largest changes in bifurcation parameters between DBS ON and OFF status based on fitted fMRI data. Electrophysiological studies in rats confirm the observed disinhibition of the thalamus during STN stimulation (Benazzouz et al., 1995, 2000). Even though our results are in line with the hypotheses formulated by the classical rate model (Albin et al., 1989), conflicting evidence from clinical studies suggests a broader perspective as reduced thalamic activity alone neither explains all symptoms of PD nor all existing therapeutic effects (Eisinger et al., 2019; Marsden and Obeso, 1994; Rodriguez-Oroz et al., 2009).
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Responses of substantia nigra pars reticulata and globus pallidus complex to high frequency stimulation of the subthalamic nucleus in rats: electrophysiological data

Abstract

Neurosci. Lett.

Neuroscience

Neuroscience

Brain

Brain Res.

Neuroscience

Lancet